bioengineering

9 Articles

An illustration of jellyfish swimming in the ocean by Rebecca Konte. The jellyfish are wearing cones on their "heads" to streamline their swimming that contain some sort of electronics inside.

The Six Million Dollar Jellyfish

March 1, 2024 by 14 Comments

What if you could rebuild a jellyfish: better, stronger, faster than it was before? Caltech now has the technology to build bionic jellyfish.

Studying the ocean given its influence on the rest of the climate is an important scientific task, but the wild pressure differences as you descend into the eternal darkness make it a non-trivial engineering problem. While we’ve sent people to the the deepest parts of the ocean, submersibles are much too expensive and risky to use for widespread data acquisition.

The researchers found in previous work that making a cyborg jellyfish was more effective than biomimetic jellyfish robots, and have now given the “biohybrid robotic jellyfish” a 3D-printed, neutrally buoyant, swimming cap. In combination with the previously-developed “pacemaker,” these cyborg jellyfish can explore the ocean (in a straight line) at 4.5x the speed of a conventional moon jelly while carrying a scientific payload. Future work hopes to make them steerable like the well-known robo-cockroaches.

If you’re interested in some other attempts to explore Earth’s oceans, how about drift buoys, an Open CTD, or an Open ROV? Just don’t forget to keep the noise down!

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Get Your Leafy Meats

June 26, 2023 by 23 Comments

Some of us jokingly refer to our hobbies as “mad science,” but [Justin] from The Thought Emporium could be one Igor away from living up to the jibe. The latest project to come out of the YouTube channel, video also after the break, outlines a map for creating an artificial organism in their new lab. The purpose is to test how far a citizen scientist can push the boundary of bioengineering. The stated goal is to create a swimming entity with a skeleton. The Thought Emporium also has a neuron project in the works, hinting at a potential crossover.

The artifishal [sic] organism has themes at the micro and macro scale. [Justin] says, “Cells are like little nano-robots. Mainly in the sense that they just follow their built-in instructions to the best of their ability.” At the multi-cellular level, the goal is to program something to actuate muscle tissue rhythmically to sustain locomotion. The method for creating living parts is decellularization and recellularization, a technique we heard about at Hackaday Belgrade.

The Thought Emporium is improving upon its protocol which removes cells from their “scaffolding” to repopulate it with the desired type, muscle in this case. Cellular scaffolds retain the shape of whatever they were, so whatever grows on them determines what they become. Once the technique of turning a leaf into muscle fibers is mastered, the next step will be creating bones with a different cell line that will mineralize the scaffold. Optimizing the processes and combining the results may show the world what is possible with the dedication of citizen bioengineers.

Regenerative medicine is looking at replacement human-parts with similar techniques. We are eager to see fish that digest plastic.

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A clear flexible PCB with a number of gold electrodes on one end. It is wrapped over a black cable to demonstrate its flexibility. A set of dashed white lines goes from one end to a zoomed in image of the circuit structure inset in the top right of the image.

Biohybrid Implant Patches Broken Nerves With Stem Cells

March 29, 2023 by 17 Comments

Neural interfaces have made great strides in recent years, but still suffer from poor longevity and resolution. Researchers at the University of Cambridge have developed a biohybrid implant to improve the situation.

As we’ve seen before, interfacing electronics and biological systems is no simple feat. Bodies tend to reject foreign objects, and transplanted nerves can have difficulty assuming new roles. By combining flexible electronics and induced pluripotent stem cells into a single device, the researchers were able to develop a high resolution neural interface that can selectively bind to different neuron types which may allow for better separation of sensation and motor signals in future prostheses.

As is typically the case with new research, the only patients to benefit so far are rats and only on the timescale of the study (28 days). That said, this is a promising step forward for regenerative neurology.

We’re no strangers to bioengineering here. Checkout how you can heal faster with electronic bandages or build a DIY vibrotactile stimulator for Coordinated Reset Stimulation (CRS).

(via Interesting Engineering)

Biological Hacking In The 19th Century Or How The World Almost Lost Wine

June 3, 2019 by 24 Comments

While it isn’t quite universal, a lot of people enjoy a glass of wine now and again. But the world faced a crisis in the 1800s that almost destroyed some of the world’s great wines. Science — or some might say hacking — saved the day, even though it isn’t well known outside of serious oenophiles. You might wonder how biological hacking occurred in the 19th century. It did. It wasn’t as fast or efficient, but fortunately for wine drinkers, it got the job done.

When people tell me about new cybersecurity threats, I usually point out that cybercrime isn’t new. People have been stealing money, tricking people into actions, and impersonating other people for centuries. The computer just makes it easier. Even computing itself isn’t a new idea. Counting on your fingers and counting with electrons is just a matter of degree. Surely, though, mashing up biology is a more recent scientific advancement, right? While it is true that CRISPR can make editing genes a weekend garage project, people have been changing the biology of plants and animals for centuries using techniques like selective breeding and grafting. Not as effective, but sometimes effective enough.

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Green Hacking: Overclocking Photosynthesis

January 5, 2019 by 30 Comments

We think of hacking as bending technology to our will. But some systems are biological,  and we’re also starting to see more hacking in that area. This should excite science fiction fans used to with reading about cultures that work with biological tech, so maybe we’ll get there in the real world too.  Hacking farm crops and animals goes back centuries, although we are definitely getting better at it. A case in point: scientists have found a way to make photosynthesis better and this should lead to more productive crops.

We learned in school that plants use carbon dioxide and sunlight to create energy and produce oxygen. But no one explained to us exactly how that happened. It seems a protein called rubisco is what causes this to happen, but unfortunately it isn’t very picky. In addition to converting carbon (from carbon dioxide) into sugar, it also converts oxygen into toxic compounds called ROS (reactive oxygen species) that most plants then have to spend energy eliminating. Scientists estimate that if you could recover the calories lost in this process, you could feed an additional 200 million people worldwide at current production levels.

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Go Small, Get Big: The Hack That Revolutionized Bioscience

June 23, 2017 by 11 Comments

Few people outside the field know just how big bioscience can get. The public tends to think of fields like physics and astronomy, with their huge particle accelerators and massive telescopes, as the natural expressions of big science. But for decades, biology has been getting bigger, especially in the pharmaceutical industry. Specialized labs built around the automation equipment that enables modern pharmaceutical research would dazzle even the most jaded CERN physicist, with fleets of robot arms moving labware around in an attempt to find the Next Big Drug.

I’ve written before on big biology and how to get more visibility for the field into STEM programs. But how exactly did biology get big? What enabled biology to grow beyond a rack of test tubes to the point where experiments with millions of test occasions are not only possible but practically required? Was it advances in robots, or better detection methodologies? Perhaps it was a breakthrough in genetic engineering?

Nope. Believe it or not, it was a small block of plastic with some holes drilled in it. This is the story of how the microtiter plate allowed bioscience experiments to be miniaturized to the point where hundreds or thousands of tests can be done at a time.

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Genetically Engineered Muscle Cells Power Tiny Bio-Robots

February 18, 2017 by 8 Comments

One of the essential problems of bio-robotics is actuators. The rotors, bearings, and electrical elements of the stepper motors and other electromechanical drives we generally turn to for robotics projects are not really happy in living systems. But building actuators the way nature does it — from muscle tissue — opens up a host of applications. That’s where this complete how-to guide on building and controlling muscle-powered machines comes in.

Coming out of the [Rashid Bashir] lab at the University of Illinois at Urbana-Campaign, the underlying principles are simple, which of course is the key to their power. The technique involves growing rings of muscle tissue in culture using 3D-printed hydrogel as forms. The grown muscle rings are fitted on another 3D-printed structure, this one a skeleton with stiff legs on a flexible backbone. Stretched over the legs like rubber bands, the muscle rings can be made to contract and move the little bots around.

Previous incarnations of this technique relied on cultured rat heart muscle cells, which contract rhythmically of their own accord. That yielded motion but lacked control, so for this go-around, [Bashir] et al used skeletal muscle cells genetically engineered to contract when exposed to light. Illuminating different parts of the muscle ring lets the researchers move the bio-bots anywhere they want. They can also use electric stimulation to control the bio-bots.

The method isn’t quite at the point where home lab biohackers will start churning out armies of bio-bots. But the paper is remarkably detailed in methods and materials, from the CAD files for 3D-printing the forms and bio-bot skeletons to a complete troubleshooting guide. It’s all there, and it could be a game changer for developing the robotic surgeons of the future.

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