What do you print with your 3D printer? Key chains? More printer parts (our favorite)? Enclosures for PC boards? At Johns Hopkins, they want to print bones. Not Halloween skeletons, either. Actual bones for use in bodies.
According to Johns Hopkins, over 200,000 people a year need head or face bone replacements due to birth defects, trauma, or surgery. Traditionally, surgeons cut part of your leg bone that doesn’t bear much weight out and shape it to meet the patient’s need. However, this has a few problems. The cut in the leg isn’t pleasant. In addition, it is difficult to create subtle curved shapes for a face out of a relatively straight leg bone.
This is an obvious application for 3D printing if you could find a suitable material to produce faux bones. The FDA allows polycaprolactate (PCL) plastic for other clinical uses and it is attractive because it has a relatively low melting point. That’s important because mixing in biological additives is difficult to do at high temperatures.
Continue reading “3D Printing Bone”
[F.Lab] is really worried that we are going to prepare a DNA sample from saliva, dish soap, and rubbing alcohol in their 3D-printed centrifuge and then drink it like a shot. Perhaps they have learned from an horrific experience, perhaps biologists have different dietary requirements. Either way, their centrifuge is really cool. Just don’t drink the result. (Ed note: it’s the rubbing alcohol.)
The centrifuge was designed in Sketch-Up and then 3D printed. They note to take extra care to get high quality 3D prints so that the rotor isn’t out of balance. To get the high speeds needed for the extraction, they use a brushless motor from a quadcopter. This is combined with an Arduino and an ESC. There are full assembly instructions on Thingiverse.
[F.Lab] has some other DIY lab equipment designs, such as this magnetic stirrer. Which we assume you could use to make a shot if you wanted to. However, it’s probably not a good idea to mix lab supplies and food surfaces. Video after the break.
Continue reading “DNA Extraction With A 3D-Printed Centrifuge”
In what is being hailed as the next great advancement in 3D printing, scientists have been able to get a 3D printed shape to change form when it is exposed to water, bringing 3D printing squarely into the realm of the fourth dimension. Although the only examples we’ve seen so far are with relatively flat prints (which arguably subtracts one “D” from the claim) the new procedure is one which is groundbreaking for the technology.
The process uses cellulose fibers which, when aligned in a particular way and exposed to water, swell in order to change shape. This is similar to how a bimetallic strip in a thermostat works, but they really took their inspiration from biological processes in plants that allow them to change shape according to environmental conditions. It’s hard to tell if this new method of printing will forever alter the landscape of 3D printing but, for now, it’s an interesting endeavor that will be worth watching. The video after the break shows a fast-motion print using the technique, followed by a demo of the print submersed in water.
We often see new technological advancements that use biology as a springboard for new ideas, and this one is no different. There have been building structures inspired by pinecones and this Processing hack inspired by squid. Biology is all around us, and any of it could be used for inspiration for your next project!
Continue reading “Take Your 3D Printing to the Next Dimension”
This is weird science. Researchers at Lawrence Berkeley National Laboratory have taken some normal bacteria and made them photosynthetic by adding cadmium sulfide nanoparticles. Cadmium sulfide is what makes the garden-variety photoresistor work. That’s strange enough. But the bacteria did the heavy lifting — they coated themselves in the inorganic cadmium — which means that they can continue to grow and reproduce without much further intervention.
Bacteria are used as workhorses in a lot of chemical reactions these days, and everybody’s trying to teach them new tricks. But fooling them into taking on inorganic light absorbing materials and becoming photosynthetic is pretty cool. As far as we understand, the researchers found a chemical pathway into which the electrons produced by the CdS would fit, and the bacteria took care of the rest. They still make acetic acid, which is their normal behavior, but now they produce much more when exposed to light.
If you want to dig a little deeper, the paper just came out in Science magazine, but it’s behind a paywall. But with a little searching, one can often come up with the full version for free. (PDF).
Or if you’d rather make electricity, instead of acetic acid, from your bacteria be our guest. In place of CdS, however, you’ll need a fish. Biology is weird.
Headline images credit: Peidong Yang
If you’ve been to downtown San Francisco lately, you might have noticed something odd about the decorative trees in the city: they’re now growing fruit. This is thanks to a group of people called the Guerrilla Grafters who are covertly grafting fruit-bearing twigs to city tress which would otherwise be fruitless. Their goal is to create a delicious, free source of food for those living in urban environments.
Biology-related hacks aren’t something we see every day, but they’re out there. For those unfamiliar with grafting, it’s a process that involves taking the flowering, fruiting, or otherwise leafy section of one plant (a “scion”) and attaching them to the vascular structure of another plant that has an already-established root system (the “stock”). The Guerrilla Grafters are performing this process semi-covertly and haven’t had any run-ins with city officials yet, largely due to lack of funding on the city’s part to maintain the trees in the first place.
This hack doesn’t stop at the biological level, though. The Grafters have to keep detailed records of which trees the scions came from, when the grafts were done, and what characteristics the stock trees have. To keep track of everything they’ve started using RFID tags. This is an elegant solution that can be small and inconspicuous, and is a reliable way to keep track of all of one’s “inventory” of trees and grafts.
It’s great to see a grassroots movement like this take off, especially when it seems like city resources are stretched so thin that the trees may have been neglected anyway. Be sure to check out their site if you’re interested in trying a graft yourself. If you’re feeling really adventurous, you can take this process to the extreme.
Thanks to [gotno] for the tip!
Hot on the heels of the 2015 Hackaday prize, with its theme of “Build stuff that matters”, comes another opportunity for hackers to make a difference. But you’ve got to think like Mother Nature for the 2016 Biomimicry Global Design Challenge.
The aim of this challenge is to transform the global food system using sustainable approaches that emulate natural process. Entries must address a problem somewhere in the food supply chain, a term that could apply to anything from soil modification to crop optimization to harvest and storage technologies. Indeed, the 2015 winner in the Student category was for a passive refrigeration system to preserve food in undeveloped areas. It’s a clever two-stage system that uses an evaporative cooling loop inspired by the way an elephant’s ears cool the giant beast, and by use of a wind-capturing funnel that mimics how animals as diverse as termites and meerkats cool their nests.
In addition to the Student category, the challenge has an Open category for teams of any composition. Up to 10 teams will be selected from the Open category to proceed to the Accelerator phase, where they’ll receive support for a six to nine month development of their design into a marketable product. The winner will be awarded the $100,000USD Ray of Hope prize, endowed by the Ray C. Anderson Foundation.
We’d love to see someone from the Hackaday community take home the 2016 prize, and there are plenty of 2015 Hackaday Prize entries that may be eligible. The deadline for submissions is 11 May 2016, so get a team together and get to work.
Open Science has been a long-standing ideal for many researchers and practitioners around the world. It advocates the open sharing of scientific research, data, processes, and tools and encourages open collaboration. While not without challenges, this mode of scientific research has the potential to change the entire course of science, allowing for more rigorous peer-review and large-scale scientific projects, accelerating progress, and enabling otherwise unimaginable discoveries.
As with any great idea, there are a number of obstacles to such a thing going mainstream. The biggest one is certainly the existing incentive system that lies at the foundation of the academic world. A limited number of opportunities, relentless competition, and pressure to “publish or perish” usually end up incentivizing exactly the opposite – keeping results closed and doing everything to gain a competitive edge. Still, against all odds, a number of successful Open Science projects are out there in the wild, making profound impacts on their respective fields. HapMap Project, OpenWorm, Sloan Digital Sky Survey and Polymath Project are just a few to name. And the whole movement is just getting started.
While some of these challenges are universal, when it comes to Biology and Biomedical Engineering, the road to Open Science is paved with problems that will go beyond crafting proper incentives for researchers and academic institutions.
It will require building hardware.
Continue reading “Open Hardware for Open Science – Interview with Charles Fracchia”