Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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a very slapdash x-ray machine on a table

Building An X-Ray Machine

September 9, 2021 by 57 Comments

While we typically encourage hackers to make their own tools or machines when practical, x-ray machines don’t usually make that list. Despite the risk of radiation, [William Osman] has done just that and built a homemade x-ray machine. After receiving an eye-watering medical bill, [William] resolves to make his own x-ray machine in the hopes of avoiding future bills. Thanks to his insurance, the total owed was smaller but still ridiculous to those who live in single-payer health care countries, but it got William thinking. What if he could make an x-ray machine to do cheap x-rays?

Armed with a cheap high voltage DC power supply he acquired from an online auction house, he started to power up his x-ray vacuum tube. A smaller power supply energizes the cathode and forms an electron beam. Then the high voltage (30-150kv) is applied as a tube voltage, accelerating the electrons into x-rays. Safety measures are taken somewhat haphazardly with Geiger counters and lead sheets. With a finger bone cast in ballistic shell [William] made his first x-ray with a long exposure on a DSLR. The next items to go in the x-ray “chamber” were a phone and a hand. The results were actually pretty decent and you can clearly see the bones.

We’ve seen homemade X-Ray machines here at Hackaday before, but not one that is constructed perhaps so haphazardly — his approach makes this obvious: don’t try this at home. Video after the break.

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New Part Day: DLP300s The Next Big Thing For Low Cost Resin Printing?

September 1, 2021 by 73 Comments

The majority of non-SLA resin 3D printers, certainly at the hacker end of the market, are most certainly LCD based. The SLA kind, where a ultraviolet laser is scanner via galvanometers over the build surface, we shall consider no further in this article.

What we’re talking about are the machines that shine a bright ultraviolet light source directly through a (hopefully monochrome) LCD panel with a 2, 4 or even 8k pixel count. The LCD pixels mask off the areas of the resin that do not need to be polymerised, thus forming the layer being processed. This technique is cheap and repeatable, hence its proliferance at this end of the market.

They do suffer from a few drawbacks however. Firstly, optical convergence in the panel causes a degree of smearing at the resin interface, which reduces effective resolution somewhat. The second issue is one of thermal control – the LCD will transmit less than 5% of the incident light, so for a given exposure at the resin, the input light intensity needs to be quite high, and this loss in the LCD results in significant internal heating and a need for active cooling.  Finally, the heating in the LCD combined with intense UV radiation degrades the LCD over time, making the LCD itself a consumable item.

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Fusion Ignition: What Does The NIF’s 1.3 MJ Yield Mean For Fusion Research?

August 30, 2021 by 37 Comments

Earlier this month, Lawrence Livermore National Laboratory (LLNL) announced to the world that they had achieved a record 1.3 MJ yield from a fusion experiment at their National Ignition Facility (NIF). Yet what does this mean, exactly? As their press release notes, the main advancement of these results will go towards the US’s nuclear weapons arsenal.

This pertains specifically to the US’s nuclear fusion weapons, which LLNL along with Los Alamos National Laboratory (LANL) and other facilities are involved in the research and maintenance of. This traces back to the NIF’s roots in the 1990s, when the stockpile stewardship program was set up as an alternative to nuclear weapons testing. Much of this research involves examining how today’s nuclear weapons degrade over time, and ways to modernize the existing arsenal.

In light of this, one may wonder what the impact of these experimental findings from the NIF are beyond merely ensuring that the principle of MAD remains intact. To answer that question, we have to take a look at inertial confinement fusion (ICF), which is the technology at the core of the NIF’s experiments.

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Golden Rice’s Appearance On Philippine Store Shelves And The Rise Of Biofortification

August 18, 2021 by 45 Comments

After decades in development, the Philippines became the first country on July 21st of this year to formally approve the commercial propagation of so-called golden rice. This is a rice strain that has been genetically engineered to produce beta-carotene in its grains. This is the same compound that has made carrots so famous, and is a significant source of vitamin A.

Getting enough vitamin A is essential for not only children and newborns, but also for pregnant and lactating women. Currently, vitamin A deficiency (VAD) is the primary cause of preventable childhood blindness and an important cause of infant mortality. While VAD is hardly the only major form of world-wide malnutrition, biofortification efforts like golden rice stand to dramatically improve the lives of millions of people around the globe by reducing the impact of VAD.

This raises questions of how effective initiatives like golden rice are likely to be, and whether biofortification of staple foods may become more common in the future, including in the US where fortification of foods has already become commonplace. Continue reading “Golden Rice’s Appearance On Philippine Store Shelves And The Rise Of Biofortification” →

Everything You Always Wanted To Know About Radioactive Lenses

August 7, 2021 by 45 Comments

We think of radioactive material as something buried away in bunkers with bombs, power plants, and maybe some exotic medical equipment. But turns out, there are little bits of radiation in the water, our soil, bananas, granite countertops, smoke detectors, and even some camera lenses. Camera lenses? A few decades ago, camera companies added rare elements like thorium to their glass to change the optical properties in desirable ways. The downside? Well, it made the lenses somewhat radioactive.  A post by [lenslegend] explains it all.

Exotic elements such as Thorium, Lanthanum and Zirconium are added to glass mixtures to create the high refractive indexes necessary in sophisticated lens designs. Selection of premium quantities of glass from the large glass pots, stringent spectrophotometric tests after stress and strain checks provide the valuable raw glass for ultimate use in lens elements.
—Konica Hexanon Lens Guide, Konica Camera Company, 1972

According to [lenslegend] the practice started in 1945 with Kodak. However, by the 1980s, consumer distaste for radioactive things and concern for factory workers ended the production of hot camera lenses.

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More Than Just Hubble: The Space Observatories Filling The Skies Today And Tomorrow

July 28, 2021 by 9 Comments

Amidst the recent news about the Hubble Space Telescope’s troubles (and triumphant resurrection), it is sometimes easy to forget that although Hubble is a pretty unique telescope, it is just one of many space-based observatories that are currently zipping overhead right now or perched in a heliocentric orbit. So what is it that makes these observatories less known than the iconic Hubble telescope?

Hubble is one of the longest-lived space telescopes so far, and it is also the only space telescope that was both launched and serviced by the Space Shuttle. None of the other telescopes have this legacy, the high-profile, or troubled history of Hubble’s intended successor: the James Web Space Telescope (JWST).

Even so, the mission profiles of these myriad other observatories are no less interesting, least of the many firsts accomplished recently such as a long-term moon-based telescope (Chang’e 3’s LUT) and those of the many upcoming and proposed missions. Let’s take a look at the space observatories many of us have never heard of.

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