[Chris Young] has a physical disability that means he can’t use a mouse very well. He typically uses Dragon Naturally Speaking for moving his mouse using voice commands but has found that it lacks some features he needs and can crash at times.
His solution to this problem was to create a device that will translate IR signals from a simple remote into mouse actions and movements. He is using an Arduino micro for this task, and as you can see in the video it seems to have worked out well for him. He has code and schematics available on his site if you would like to recreate this yourself.
[Chris] has actually built several accessibility devices for himself and others. You should check out his blog for more, including his thoughts on the cost of commercial accessibility equipment vs DIY. If you think you would like to try making a device to help someone with a physical disability access a computer, hop on over to thecontrollerproject.com and join up on the forums.