Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Green Roofs Could Help Improve Solar Panel Efficiency

There’s been a movement in architecture over the past couple of decades to help tie together large urban developments with plant life and greenery. We’ve seen a few buildings, and hundreds more renders, of tall skyscrapers and large buildings covered in vegetation.

The aesthetic is often a beautiful one, but the idea is done as much for its tangible benefits as for the sheer visual glory. Naturally, there’s the obvious boost from plants converting carbon dioxide into delicious, life-giving oxygen. However, greenery on the roofs of buildings could also help improve the output of solar installations, according to a recent study from Sydney, Australia.

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Farewell Sir Clive Sinclair; Inspired A Generation Of Engineers

It is with sadness that we note the passing of the British writer, engineer, home computer pioneer, and entrepreneur, Sir Clive Sinclair, who died this morning at the age of 81 after a long illness. He is perhaps best known among Hackaday readers for his ZX series of home computers from the 1980s, but over a lifetime in the technology industry there are few corners of consumer electronics that he did not touch in some way.

Sinclair’s first career in the 1950s was as a technical journalist and writer, before founding the electronics company Sinclair Radionics in the 1960s. His output in those early years was a mixture of miniature transistor radios and Hi-Fi components, setting the tone for decades of further tiny devices including an early LED digital watch at the beginning of the 1970s, miniature CRT TVs in the ’70s and ’80s, and another tiny in-ear FM radio which went on sale in the ’90s.

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Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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The World’s First Autonomous Electric Cargo Ship Is Due To Set Sail

Maritime shipping is big business, with gigantic container ships responsible for moving the vast majority of the world’s goods from point A to points B, C and D. Of course, there’s a significant environmental impact from all this activity, something ill befitting the cleaner, cooler world we hope the future will be. Thus, alternatives to the fossil fuel burning ships of old must be found. To that end, Norwegian company Yara International has developed a zero-emission ship by the name of Yara Birkeland, which aims to show the way forward into a world of electric, autonomous sea transport. 

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Pinning Tails On Satellites To Help Prevent Space Junk

Low Earth orbit was already relatively crowded when only the big players were launching satellites, but as access to space has gotten cheaper, more and more pieces of hardware have started whizzing around overhead. SpaceX alone has launched nearly 1,800 individual satellites as part of its Starlink network since 2019, and could loft as many as 40,000 more in the coming decades. They aren’t alone, either. While their ambitions might not be nearly as grand, companies such as Amazon and Samsung have announced plans to create satellite “mega-constellations” of their own in the near future.

At least on paper, there’s plenty of room for everyone. But what about when things go wrong? Should a satellite fail and become unresponsive, it’s no longer able to maneuver its way out of close calls with other objects in orbit. This is an especially troubling scenario as not everything in orbit around the Earth has the ability to move itself in the first place. Should two of these uncontrollable objects find themselves on a collision course, there’s nothing we can do on the ground but watch and hope for the best. The resulting hypervelocity impact can send shrapnel and debris flying for hundreds or even thousands of kilometers in all three dimensions, creating an extremely hazardous situation for other vehicles.

One way to mitigate the problem is to design satellites in such a way that they will quickly reenter the Earth’s atmosphere and burn up at the end of their mission. Ideally, the deorbit procedure could even activate automatically if the vehicle became unresponsive or suffered some serious malfunction. Naturally, to foster as wide adoption as possible, such a system would have to be cheap, lightweight, simple to integrate into arbitrary spacecraft designs, and as reliable as possible. A tall order, to be sure.

But perhaps not an impossible one. Boeing subsidiary Millennium Space Systems recently announced it had successfully deployed a promising deorbiting device developed by Tethers Unlimited. Known as the Terminator Tape, the compact unit is designed to rapidly slow down an orbiting satellite by increasing the amount of drag it experiences in the wispy upper atmosphere.

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NASA Are Squaring Up Against The Asteroid Threat

The world faces many terrestrial crises right now, so it’s easy to forget that giant space rocks may one day threaten the very existence of entire civilizations. Yes, the threat of asteroid strikes is a remote one, but nevertheless something humanity may have to face one day, and one day soon.

NASA takes the issue seriously, and has staffed its Planetary Defence Coordination Office since 2016. In service to these efforts, it’s also developing a mission to research how dangerous androids may be deflected. The Double Asteroid Redirection Test, or DART, is set to launch within the next year. Continue reading “NASA Are Squaring Up Against The Asteroid Threat”