You are probably familiar with the work of [Ben Heckendorn]. His latest commercial project, the one handed Access Controller, is now available for pre-order. A well known modder, he has created several unique video game console adaptations including a scratch built one handed Xbox 360 controller.
A unique feature of this controller is that it allows you to change the location of the buttons/joysticks. This modular design can be swapped and customized depending on your needs. Ben is including a guide for creating your own modules, should you be so inclined. The device uses 2.4Ghz wireless to communicate and is available for $129.99.
Since we know you are more interested in hacks than gadgets, be sure to checkout Heckendorn’s nice collection of how-tos on Engadget.