dna

45 Articles

Genetic Testing With Lego

October 11, 2011 by 7 Comments

From the dark recesses of the Internet circa 2009 comes the BioBrick-A-Bot, a liquid handling system for molecular biologists.

The 2009 iGEM competition was a student competition to build devices for synthetic biology. The BioBrick-A-Bot’s goal is to build a simple, low-cost liquid handling system that sucks liquids out of petri dishes and into vials.

Like most lab equipment, the commercial version of this tech is insanely expensive – about 10 grand for a commercial liquid handling robot. The BioBrick-A-Bot is made nearly entirely out of LEGO parts, so the cost of the entire system was brought down to about $700.

There are two main parts to the BioBrick-A-Bot. The Alpha module holds four pipette on a delta platform We’ve seen this type of robot built out of LEGO before, but moving liquids is new territory. The Phi module contains all the mechanics to suck microliters of liquid into a pipette and spit them out into vials.

The BioBrick-A-Bot didn’t win the 2009 iGEM competition (that honor was taken by students from Heidelberg Cambridge), but we’d take a LEGO robot any day of the week. Check out the demo after the break.

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Simulated Annealing

December 10, 2008 by 24 Comments

annealing

Here’s an update on our earlier post about genetic programming. Altered Qualia has posted a new implementation of [Ron Alsing]’s idea. It starts with 50 polygons and then randomly changes one parameter with each optimization step. If the the change results in fewer differences from the target image, it’s kept as the new best DNA. This search method is similar to simulated annealing. The image above is the result of 1500 good mutations out of 35900 possible. The implementation lets you choose any image, but smaller means the fitness calculation is faster. It’s written in JavaScript using the <canvas> environment. You’ll definitely get better performance using newer browser builds.

[Original image by R Stevens]

[via Waxy]

24C3 Hacking DNA

January 5, 2008 by 28 Comments

[Drew Endy]’s Programming DNA talk was by far the most interesting talk we saw at Chaos Communication Congress. No, DNA doesn’t have much to do with computers, but he points out that hacking principles can be applied just the same. Right now engineers are reversing genetic code and compiling building blocks for creating completely arbitrary organisms. This talk was designed to bootstrap the hacking community so that we can start using and contributing standard biological parts to an open source collection of genetic functions.

You should definitely watch the video to get a good idea of where biohacking is at today. You can find a higher quality version of the video in the archives.