An illustration of two translucent blue hands knitting a DNA double helix of yellow, green, and red base pairs from three colors of yarn. Text in white to the left of the hands reads: "Evo 2 doesn't just copy existing DNA -- it creates truly new sequences not found in nature that scientists can test for useful properties."

LLMs Coming For A DNA Sequence Near You

April 24, 2025 by Navarre Bartz 16 Comments

While tools like CRISPR have blown the field of genome hacking wide open, being able to predict what will happen when you tinker with the code underlying the living things on our planet is still tricky. Researchers at Stanford hope their new Evo 2 DNA generative AI tool can help.

Trained on a dataset of over 100,000 organisms from bacteria to humans, the system can quickly determine what mutations contribute to certain diseases and what mutations are mostly harmless. An “area we are hopeful about is using Evo 2 for designing new genetic sequences with specific functions of interest.”

To that end, the system can also generate gene sequences from a starting prompt like any other LLM as well as cross-reference the results to see if the sequence already occurs in nature to aid in predicting what the sequence might do in real life. These synthetic sequences can then be made using CRISPR or similar techniques in the lab for testing. While the prospect of building our own Moya is exciting, we do wonder what possible negative consequences could come from this technology, despite the hand-wavy mention of not training the model on viruses to “to prevent Evo 2 from being used to create new or more dangerous diseases.”

We’ve got you covered if you need to get your own biohacking space setup for DNA gels or if you want to find out more about powering living computers using electricity. If you’re more curious about other interesting uses for machine learning, how about a dolphin translator or discovering better battery materials?

Bioelectronic implants with size reference

Batteries Not Included: Navigating The Implants Of Tomorrow

November 19, 2024 by Heidi Ulrich 19 Comments

Tinkerers and tech enthusiasts, brace yourselves: the frontier of biohacking has just expanded. Picture implantable medical devices that don’t need batteries—no more surgeries for replacements or bulky contraptions. Though not all new (see below), ChemistryWorld recently shed new light on these innovations. It’s as exciting as it is unnerving; we, as hackers, know too well that tech and biology blend a fine ethical line. Realising our bodies can be hacked both tickles our excitement and unsettlement, posing deeper questions about human-machine integration.

Since the first pacemaker hit the scene in 1958, powered by rechargeable nickel-cadmium batteries and induction coils, progress has been steady but bound by battery limitations. Now, researchers like Jacob Robinson from Rice University are flipping the script, moving to designs that harvest energy from within. Whether through mechanical heartbeats or lung inflation, these implants are shifting to a network of energy-harvesting nodes.

From triboelectric nanogenerators made of flexible, biodegradable materials to piezoelectric devices tapping body motion is quite a leap. John Rogers at Northwestern University points out that the real challenge is balancing power extraction without harming the body’s natural function. Energy isn’t free-flowing; overharvesting could strain or damage organs. A topic we also addressed in April of this year.

As we edge toward battery-free implants, these breakthroughs could redefine biomedical tech. A good start on diving into this paradigm shift and past innovations is this article from 2023. It’ll get you on track of some prior innovations in this field. Happy tinkering, and: stay critical! For we hackers know that there’s an alternative use for everything!

A line-art diagram of the microfluidic device. On the left, in red text, it says "Fibrillization trigger (CPB pH 5.0). There is a rectangular outline of the chip in grey, with a sideways trapezoid on the left side narrowing until it becomes an arrow on the right. At the right is an inset picture of the semi-transparent microfluidic chip and the text "Negative Pressure (Pultrusion)." Above the trapezoid is the green text "MaSp2 solution" and below is "LLPS trigger (CPB pH 7.0)" in purple. The green, purple, and red text correspond with inlets labeld 1, 2, and 3, respectively. Three regions along the arrow-like channel from left to right are labeled "LLPS region," "pH drop," and in a much longer final section "Fiber assembly region."

Synthetic Spider Silk

February 8, 2024 by Navarre Bartz 7 Comments

While spider silk proteins are something you can make in your garage, making useful drag line fibers has proved a daunting challenge. Now, a team of scientists from Japan and Hong Kong are closer to replicating artificial spider silk using microfluidics.

Based on how spiders spin their silk, the researchers designed a microfluidic device to replicate the chemical and physical gradients present in the spider. By varying the amount of shear and chemical triggers, they tuned the nanostructure of the fiber to recreate the “hierarchical nanoscale substructure, which is the hallmark of native silk self-assembly.”

We have to admit, keeping a small bank of these clear, rectangular devices on our desk seems like a lot less work than keeping an army of spiders fed and entertained to produce spider silk Hackaday swag. We shouldn’t expect to see a desktop microfluidic spider silk machine this year, but we’re getting closer and closer. While you wait, why not learn from spiders how to make better 3D prints?

If you’re interesting in making your own spider silk proteins, checkout how [Justin Atkin] and [The Thought Emporium] have done it with yeast. Want to make your spider farm spiders have stronger silk? Try augmenting it with carbon.

a) Schematic illustration of energy storage process of succulent plants by harnessing solar energy with a solar cell, and the solar cell converts the energy into electricity that can be store in APCSCs of succulent plants, and then utilized by multiple electrical appliances. b–d) The energy is stored in cactus under sunlight by solar cell and then power light strips of Christmas tree for decoration.

Succulents Into Supercapacitors

January 11, 2024 by Navarre Bartz 17 Comments

Researchers in Beijing have discovered a way to turn succulents into supercapacitors to help store energy. While previous research has found ways to store energy in plants, it often required implants or other modifications to the plant itself to function. These foreign components might be rejected by the plant or hamper its natural functions leading to its premature death.

This new method takes an aloe leaf, freeze dries it, heats it up, then uses the resulting components as an implant back into the aloe plant. Since it’s all aloe all the time, the plant stays happy (or at least alive) and becomes an electrolytic supercapacitor.

Using the natural electrolytes of the aloe juice, the supercapacitor can then be charged and discharged as needed. The researchers tested the concept by solar charging the capacitor and then using that to run LED lights.

This certainly proposes some interesting applications, although we think your HOA might not be a fan. We also wonder if there might be a way to use the photosynthetic process more directly to charge the plant? Maybe this could recharge a tiny robot that lands on the plants?

3D printed ring with 4-integrated electrodes for measuring bioimpedance for measuring blood pressure from the finger

Smart Ring Measures Blood Pressure

November 6, 2023 by Orlando Hoilett 17 Comments

Continuous blood pressure monitoring has always been a major challenge for the biohacking community. Those giant arm cuffs aren’t exactly the kind of thing you want to wear all day and the wrist monitors aren’t super great either. So, [Kaan] and his research team set out to create a better continuous blood pressure monitor. This time as a ring.

When your heart beats, the volume of blood in the blood vessels increases ever so slightly. This increase in volume results in a decrease in electrical impedance because blood is fairly conductive. We’ve seen a similar volume measurement using light for detecting heart rate, but [Kaan] says with impedance, you won’t need to worry about the effect of skin tone on the accuracy of the measurement.

As far as the hardware is concerned, they inject a small, constant 10 kHz sinusoidal current into the finger through 2 current-injecting electrodes, and then measure the resulting voltage drop across the finger with two sensing electrodes, a standard 4-probe Kelvin approach. Their results seem pretty good. They are within 5.27 millimeters of mercury (mmHg) of the gold standard for systolic blood pressure and 3.87 mmHg for diastolic blood pressure across 10 subjects, which they say are within the American Association for the Advancement of Medical Instrumentation’s (AAMI) guidelines. That’s definitely something to catch your attention.

We’ve seen several attempts to measure blood pressure using the analogous photoplethysmography technique, but those generally don’t seem to work out. Will the impedance plethysmography approach overcome the optical technique’s shortcomings? Only time will tell.

Bespoke Implants Are Real—if You Put In The Time

September 6, 2023 by Brian McEvoy 23 Comments

A subset of hackers have RFID implants, but there is a limited catalog. When [Miana] looked for a device that would open a secure door at her work, she did not find the implant she needed, even though the lock was susceptible to cloned-chip attacks. Since no one made the implant, she set herself to the task. [Miana] is no stranger to implants, with 26 at the time of her talk at DEFCON31, including a couple of custom glowing ones, but this was her first venture into electronic implants. Or electronics at all. The full video after the break describes the important terms.

The PCB antenna in an RFID circuit must be accurately tuned, which is this project’s crux. Simulators exist to design and test virtual antennas, but they are priced for corporations, not individuals. Even with simulators, you have to know the specifics of your chip, and [Miana] could not buy the bare chips or find a datasheet. She bought a pack of iCLASS cards from the manufacturer and dissolved the PVC with acetone to measure the chip’s capacitance. Later, she found the datasheet and confirmed her readings. There are calculators in lieu of a simulator, so there was enough information to design a PCB and place an order.

The first batch of units can only trigger the base station from one position. To make the second version, [Miana] bought a Vector Network Analyzer to see which frequency the chip and antenna resonated. The solution to making adjustments after printing is to add a capacitor to the circuit, and its size will tune the system. The updated design works so a populated board is coated and implanted, and you can see an animated loop of [Miana] opening the lock with her bare hand.

Biohacking can be anything from improving how we read our heart rate to implanting a Raspberry Pi.

Continue reading “Bespoke Implants Are Real—if You Put In The Time” →

The project's wrist-worn heartrate sensor shown on someone's hand, Caption: Our device has three main components: watch electronics (arrow to watch display), organism enclosure (arrow to the 3D-printed case of the watch) and our living organism physarum polycephalum a.k.a slime mold.

What If Your Day-To-Day Devices Were Alive?

November 2, 2022 by Arya Voronova 9 Comments

We take advantage of a variety of devices in our day-to-day life, and we might treat them as just pieces of hardware, elements fulfilling a certain purpose — forgotten about until it’s time to use them. [Jasmine Lu] and [Pedro Lopes] believe that these relationships could work differently, and their recent paper describes a wearable device that depends on you as much as you depend on it. Specifically, they built wrist-worn heart rate sensors and designed a living organism into these, in a way that it became vital to the sensor’s functioning.

The organism in question is Physarum polycephalum, a slime mold that needs water to stay alive and remain conductive — if you don’t add water on a regular basis, it eventually dries out and hibernates, and adding water then will revive it. The heart rate sensor’s power rail is controlled by the mold, meaning the sensor functions only as long as you keep the mold alive and healthy. In their study, participants were asked to wear this device for one-two weeks, and the results go way beyond what we would expect from, say, a Tamagotchi — with the later pages describing participant reactions and observations being especially impressive.

For one, the researchers found that the study participants developed a unique sense of connection towards the slime mold-powered device, feeling senses of responsibility and reciprocity, and a range of other feelings you wouldn’t associate with a wearable. Page 9 of the paper tells us how one participant got sick, but still continued caring for the organism out of worry for its well-being, another participant brought her “little pet mold friend” on a long drive; most participants called the slime a “friend” or a “pet”. A participant put it this way:

[…] it’s always good to be accompanied by some living creature, I really like different, animals or plants. […] carrying this little friend also made me feel happy and peaceful.

There’s way more in the paper, but we wouldn’t want to recite it in full — you should absolutely check it out for vivid examples of experiences that you’d never have when interacting with, say, your smartphone, as well as researchers’ analysis and insights.

With such day-to-day use devices, developing a nurturing relationship could bring pleasant unexpected consequences – perhaps, countering the “kept on a shelf since purchase” factor, or encouraging repairability, both things to be cherished. If you’ve ever overheard someone talking about their car or laptop as if it were alive, you too might have a feeling such ideas are worth exploring. Of course, not every device could use a novel aspect like this, but if you wanted to go above and beyond, you could even build a lamp that needs to be fed to function.

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