[Debraj] wrote in about his 2-wire serial backpack he developed for a Graphic LCD screen. It’s build on a hunk of protoboard and uses a pair of 595 shift registers to translate incoming serial data to the parallel interface which is used by the LCD screen. It takes more time to push commands this way, but the interface is still quite snappy as you can see in the clip after the jump.
The real trick here is how the hardware has been configured to get away without a third wire for latching the shift registers (if you need a primer on 595 chips check out this feature). The idea of using a latch is that all of the data can be shifted in over the serial pin before it appears on the output pins. Otherwise, the GLCD would see each bit as it shifts into the register, wreaking havoc on its communication protocol. [Debraj] gets around this by using a diode AND gate trick he learned from this other serial LCD project.
One good thing about this method is the 595 chips have a wide range of control voltage that will allow you to drive this with 3.3V or 5V microcontrollers. But you do need to implement the communication protocol and push those commands via serial. For nearly the same cost in chips something like an ATtiny2313 could be substituted to make an even simpler addressing scheme — or even switch to 1-wire protocol. But you’d then lose the wide input voltage tolerance.