Cornell University enhanced electron microscopy using a technique known as ptychography in 2018. At the time, it allowed an electron microscope to resolve things three times smaller than previously possible. But that wasn’t enough. The team has now doubled that resolution by improving on their previous work.
The team says that the images are so precise that the only blurring is due to the thermal motion of the atoms themselves. This could mean that you won’t see a further improvement in resolution in the future.
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There’s an old joke that you can’t trust atoms — they make up everything. But until fairly recently, there was no real way to see individual atoms. You could infer things about them using X-ray crystallography or measure their pull on tiny probes using atomic force microscopes, but not take a direct image. Until now. Two laboratories recently used cryo-electron microscopy to directly image atoms in a protein molecule with a resolution of about 1.2 x 10-7 millimeters or 1.2 ångströms. The previous record was 1.54 ångströms.
Recent improvements in electron beam technology helped, as did a device that ensures electrons that strike the sample travel at nearly the same speeds. The latter technique resulted in images so clear, researchers could identify individual hydrogen atoms in the apoferritin molecule and the water surrounding it.
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