When [kiwih] picked up an Agilent 54621A scope, he was amused that it had a floppy disk. At one time, it was high-tech to use a disk to transfer scope data to your computer. Today, not so much. However, on the back was a serial port. Surely it was possible to read data from there. It is, and what results is a nice walkthrough of finding the port’s info and interfacing with it using Python.
Normally, you’d use the included BenchLinkXL software to grab data from the port, but that software is so old it would not run under Windows 10 or Wine. Searching didn’t turn up much on the serial port, but it did locate a manual for a similar Agilent scope. That manual wasn’t too helpful since it assumed you were connecting via a LAN or USB. However, it did make reference to an older model that was also similar and that was the key to finding a manual that did explain the serial port protocol.
The command set looks suspiciously like SCPI — Standard Commands for Programmable Instruments — which is a layer on top of the GPIB protocol. Many scopes speak that language, so that’s not surprising. That also means if you are in the mood to communicate with an SCPI scope, you might find the code useful, even if you don’t use a serial port or have this exact Agilent model.