As any good hacker (or scientist) knows, sometimes you find the tools you need in unexpected places. For one group of MIT scientists, that place is a box of Lego. Graduate student [Crystal Owens] was looking for new ways to make a cheap, simple microfluidics kit. This technique uses the flow of small amounts of liquid to do things like sort cells, test the purity of liquids and much more. The existing lab tools aren’t cheap, but [Crystal] realized that Lego could do the same thing. By cutting channels into the flat surface of a Lego brick with a precise CNC machine and covering the side of the brick with glass, she was able to create microfluidic tools like mixers, drop makers and others. To create a fluid resistor, she made the channel smaller. To create a larger microfluidic system, she mounted the blocks next to each other so the channels connected. The tiny gap between blocks (about 100 to 500 microns) was dealt with by adding an O-ring to the end of each of channel. Line up several of these bricks, and you have a complete microfluidic system in a few blocks, and a lab that only costs a few dollars.
Of course, there are limitations. The ABS plastic Lego bricks are made from can’t handle chemicals like organic solvents, and the channels can’t be smaller than about 10 microns wide, which is too wide for some microfluidic techniques. These issues aside, it’s a great and inventive idea, and MIT is currently working on a web site that will show you how to make your own Lego microfluidics lab.