Emmanuelle Charpentier And Jennifer Doudna Sharpened Mother Nature’s Genetic Scissors And Won The Nobel For It

It sounds like science fiction — and until 2012, the ability to cheaply and easily edit strings of DNA was exactly that. But as it turns out, CRISPR/Cas9 gene editing is a completely natural function in which bacteria catalogs its interactions with viruses by taking a snippet of the virus’ genetic material and filing it away for later.

Now, two women have won the 2020 Nobel Prize in Chemistry “for developing a method for genome editing”. Emmanuelle Charpentier and Jennifer Doudna leveraged CRISPR into a pair of genetic scissors and showed how sharp they are by proving that they can edit any string of DNA this way. Since Emmanuelle and Jennifer published their 2012 paper on CRISPR/Cas9, researchers have used these genetic scissors to create drought-resistant plants and look for new gene-based cancer therapies. Researchers are also hoping to use CRISPR/Cas9 to cure inherited diseases like Huntington’s and sickle cell anemia.

The discovery started with Emmanuelle Charpentier’s investigation of the Streptococcus pyogenes bacterium. She was trying to understand how its genes are regulated and was hoping to make an antibiotic. Once she teamed up with Jennifer Doudna, they found a scientific breakthrough instead.

Dr. Emmanuelle Charpentier via Wikimedia Commons

Emmanuelle Charpentier Fights Flesh-Eating Bacteria

Emmanuelle Charpentier was born December 11th, 1968 in Juvisy-sur-Orge, France. She studied biochemistry, microbiology, and genetics at the Pierre and Marie Curie University, which is now known as Sorbonne University. Then she received a research doctorate from Institut Pasteur and worked as a university teaching assistant and research scientist. Dr. Charpentier is currently a director at the Max Planck Institute for Infection Biology in Berlin, and in 2018, she founded an independent research unit.

Upon completion of her doctorate, Dr. Charpentier spent a few years working in the States before winding up at the University of Vienna where she started a research group. Her focus was still on the bacteria Streptococcus pyogenes, which causes millions of people to suffer through infections like tonsillitis and impetigo each year. It also causes sepsis, which officially makes it a flesh-eating bacterium.

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Hackaday Links: October 18, 2020

Remember subliminal advertising? The idea was that a movie theater operator would splice a single frame showing a bucket of hot buttered popcorn into a movie, which moviegoers would see and process on a subconcious level and rush to the concession stand to buy the tub o’ petrochemical-glazed starch they suddenly craved. It may or may not work on humans, but it appears to work on cars with advanced driver assistance, which can be spoofed by “phantom street signs” flashed on electronic billboards. Security researchers at Ben Gurion University stuck an image of a stop sign into a McDonald’s ad displayed on a large LCD screen by the side of the road. That was enough to convince a Tesla Model X to put on the brakes as it passed by the sign. The phantom images were on the screen anywhere from an eighth of a second to a quarter second, so these aren’t exactly subliminal messages, but it’s still an interesting attack that bears looking into. And while we’re skeptical about the whole subliminal advertising thing in the first place, for some reason we really want a bacon cheeseburger right now.

Score one for the good guys in the battle against patent trolls. Mycroft AI, makers of open-source voice assistants, proudly announced their latest victory against what they claim are patent trolls. This appears to be one of those deals where a bunch of investors get together and buy random patents, and then claim that a company that actually built something infringes on their intellectual property. Mycroft got a letter from one such entity and decided to fight it; they’ve won two battles so far against the alleged trolls and it looks pretty good going forward. They’re not pulling their punches, either, since Mycroft is planning to go after the other parties for legal expenses and punitive damages under the State of Missouri’s patent troll legislation. Here’s hoping this sends a message to IP squatters that it may not be worth the effort and that their time and money are better spent actually creating useful things.

Good news from Mars — The Mole is finally completely buried! We’ve been following the saga of the HP³, or “Heat Flow and Physical Properties Package” aboard NASA’s Mars InSight lander for quite a while. The self-drilling “Mole”, which is essentially the guts of an impact screwdriver inside a streamlined case, has been having trouble dealing with the Martian regolith, which is simultaneously too soft to offer the friction needed to keep the penetrator in its hole, but also too hard to pierce in places where there is a “duricrust” of chemically amalgamated material below the surface. It took a lot of delicate maneuvers with the lander’s robotic arm to get the Mole back on track, and it’s clearly not out of the woods yet — it needs to get down to three meters depth or so to do the full program of science it was designed for.

If watching Martian soil experiments proceed doesn’t scratch your itch for space science, why not try running your own radio astronomy experiments? Sure, you could build your own radio telescope to do that, but you don’t even have to go that far — just log into PICTOR, the free-to-use radio telescope. It’s a 3.2-m parabolic dish antenna located near Athens, Greece that’s geared toward hydrogen line measurements of the galaxy. You can set up an observation run and have the results mailed back to you for later analysis.

Here’s a fun, quick hack for anyone who hates the constant drone of white noise coming from fans. Build Comics apparently numbers themselves among that crowd, and decided to rig up a switch to turn on their fume extractor only when the soldering iron is removed from its holder. This hack was executed on a classic old Weller soldering station, but could easily be adapted to Hakko or other irons

And finally, if you’ve never listened to a Nobel laureate give a lecture, here’s your chance. Andrea Ghez, co-winner of the 2020 Nobel Prize in physics for her work on supermassive black holes, will be giving the annual Maria Goeppert Mayer lecture at the University of Chicago. She’ll be talking about exactly what she won the Nobel for: “The Monster at the Heart of Our Galaxy”, the supermassive black hole Sagittarius A*. We suspect the talk was booked before the Nobel announcement, so in normal times the room would likely be packed. But one advantage to the age of social distancing is that everything is online, so you can tune into a livestream of the lecture on October 22.