lactose intolerance

2 Articles

A biohacker with her lactose-rich slurry

Biohack Your Way To Lactose Tolerance (Through Suffering)

December 13, 2025 by 49 Comments

A significant fraction of people can’t handle lactose, like [HGModernism]. Rather than accept a cruel, ice cream free existence, she decided to do something you really shouldn’t try: biohacking her way to lactose tolerance.

The hack is very simple, and based on a peer reviewed study from the 1990s: consume lactose constantly, and suffer constantly, until… well, you can tolerate lactose. If you’re lactose intolerant, you’re probably horrified at the implications of the words “suffer constantly” in a way that those milk-digesting-weirdos could never understand. They probably think it is hyperbole; it is not. On the plus side, [HGModernism]’s symptoms began to decline after only one week.

The study dates back to the 1980s, and discusses a curious phenomenon where American powdered milk was cluelessly distributed during an African famine. Initially that did more harm than good, but after a few weeks mainlining the white stuff, the lactose-intolerant Africans stopped bellyaching about their bellyaches.

Humans all start out with a working lactase gene for the sake of breastfeeding, but in most it turns off naturally in childhood. It’s speculated that rather than some epigenetic change turning the gene for lactose tolerance back on — which probably is not possible outside actual genetic engineering — the gut biome of the affected individuals shifted to digest lactose painlessly on behalf of the human hosts. [HGModernism] found this worked but it took two weeks of chugging a slurry of powdered milk and electrolyte, formulated to avoid dehydration due to the obvious source of fluid loss. After the two weeks, lactose tolerance was achieved.

Should you try this? Almost certainly not. [HGModernism] doesn’t recommend it, and neither do we. Still, we respect the heck out any human willing to hack the way out of the limitations of their own genetics. Speaking of, at least one hacker did try genetically engineering themselves to skip the suffering involved in this process. Gene hacking isn’t just for ice-cream sundaes; when applied by real medical professionals, it can save lives.

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Biohacking Lactose Intolerance

February 14, 2018 by 73 Comments

Would you pop a homemade pill containing genetically engineered virus particles just so that you can enjoy a pizza? Not many people would, but then again, if you’ve experienced the violent reaction to lactose that some people have, you just might consider it.

Such was the position that [The Thought Emporium] found himself in at age 16, suddenly violently lactose intolerant and in need of a complete diet overhaul. Tired of scanning food labels for telltale signs of milk products and paying the price for the inevitable mistakes, he embarked on a journey of DIY gene therapy to restore his ability to indulge in comfort foods. The longish video below details a lot of that journey; skip to 15:40 if you want to cut to the chase. But if you’re at all interested in the processes of modern molecular biology, make sure you watch the whole thing. The basic idea here is to create an innocuous virus that carries the lac gene, which encodes the enzyme β-galactosidase, or lactase, and use it to infect the cells of his small intestine. There the gene will hopefully be expressed, supplementing the supply of native enzyme, which in most adult humans is no longer expressed at the levels it was when breast milk was our primary food.

Did it work? We won’t ruin the surprise, but in any case, the video is a fascinating look at mammalian cell transfection and other techniques of genetic engineering that are accessible to the biohacker. Still, it takes some guts to modify your own guts, but bear in mind that this is someone who doesn’t mind inserting magnetic implants in his fingers.

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