How Film Industry Data Website The-Numbers.com Got Mauled By Bots

July 25, 2026 by Maya Posch 20 Comments

A lot has been made about the increase of automated traffic on the Internet, with the past years LLM-related crawlers having quite literally swarmed the picture here. Not only does this drive up traffic, it also increases load on web servers, whose owners find themselves faced with increased hosting costs. This recently led to The-Numbers.com going offline for a while as automated traffic was quite literally destroying their bottom line.

This saga is covered by [Stephen Follows], who had a chance to talk with the founder and CEO of the site, [Bruce Nash], after the site went basically offline for a few months. Since the website both licenses data for commercial purposes as well as offering the free access on its website, there were accusations of this being a ‘rug pull’.

The site was started in 1997, as a static HTML site on Geocities where [Bruce] provided box office analyses for investment purposes. Since that beginning traffic was generally polite, with human visitors and usually well-behaved search engine crawlers. Then around 2024 the first wave of scraper bots arrived, followed by a larger wave around December of 2025.

Despite implementing a few mitigations, such as LLM-targeted text, the increased traffic and the resulting load on a site architecture that was never designed for this ultimately led to a collapse. One of the major sources of traffic turned out to be from so-called ‘prediction markets’, like Polymarket, whose bots absolutely hammered the site.

Fortunately for [Bruce] and his team they do not rely on the free website for income, but they have had to massively rework the site’s architecture to bring back a semblance of the original features. As noted in the article, the amount of crawling traffic by these LLMs and ‘agentic AI’ tools is exponentially more than that for search engines, which makes this a major challenge.

Issues like these is why services such as Cloudflare are offering blocking features for such automated traffic. After all, unless such traffic is of use to you, you may as well treat it like a DDoS attack and cut it off at the root.

Thanks to [Ben] for the tip.

Fast Volumetric Imaging Of Seizures With Adaptive Optics Light Sheet Microscopy

July 24, 2026 by Maya Posch No comments

Seizure in zebrafish larva imaged using AO setup. (Credit: Bingxi Liu et al., Biomedical Optics Express, 2026)

Key to understanding something like epilepsy is to be able to record highly transient events in biological tissues. Generally this is done using light sheet microscopy, which provides effectively a 2D ‘slice’ of the tissue in question, but to observe a brief event in a larger biological system you need to be able to rapidly change the layer and focus between the virtual layers. This is what [Bingxi Liu] et al. al did using adaptive optics with an electrically tunable lens (ETL) in order to capture seizures in the brain of zebrafishes.

Their system can capture a volume of 499 × 499 × 150 μm³ at 4 volumes per second, which is large enough to fit optically transparent zebrafish larva into. The optical setup is shown in the above image, with the design based on the OpenSPIM platform for selective plane illumination microscopy.

Here the 488 nm laser provides the illumination (excitation) of the layer, while the 543 nm laser is for calibration purposes. The ETL is thus in the imaging path that allows for capturing by a digital camera, while a beam splitter directs part of the captured data to a Shack-Hartmann wave front sensor (SHWFS), which is part of the adaptive optics system.

After a seizure was induced in the zebrafish larva using the drug pentylenetetrazol the results were recorded using this system. It showed the seizure’s origin in the posterior brain, with subsequent propagation to the anterior before subsiding gradually over tens of seconds.

This system should be quite useful even outside of seizure research, as there are a lot of 3D systems in biology where having a relatively high-speed microscopic capture can be very revealing.

Codeberg Bans Cryptocurrency And LLM-Generated Code Projects

July 24, 2026 by Maya Posch 88 Comments

Community-led open source project hosting site Codeberg has formally announced that projects whose code is largely or fully machine-generated through LLMs and other ‘AI’ tools will no longer be welcome. This follows on the heels of a similar ban on cryptocurrency-related projects.

The community vote was on two issues, the first being the notion that scraping of project code for the use in LLMs should be forbidden, which was a motion that easily passed. The second motion was on disallowing projects whose code was substantially generated by LLMs like Claude, OpenAI Codex, and similar. This motion passed with 358 in favor versus 144 against.

In the earlier linked blog post the reasoning behind especially this second issue is expanded upon, covering not only ‘license whitewashing’, but also the direct and indirect hardware costs, with the expanding ‘AI’ datacenter hyperscaling having massively increased hardware costs for Codeberg over the past years, as the costs have been largely externalized.

Also covered is the aspect of these LLM-based tools destroying the OSS community, which is something that is backed up by recent studies. Even if we ignore that such LLM-tools are destroying the cognitive abilities of its users, there’s an argument to be made that if LLM-scraping is disallowed, then it’s consistent to also not allow LLM-generated code.

In the Terms of Use you can see these changes, both for LLMs and for cryptocurrency projects.

Thanks to [mk-fg] for the tip.

Targeting Allele-Specific Faulty MRNA In SCNA2 Mutation Patients

July 23, 2026 by Maya Posch 1 Comment

When an individual is born with genetic defects, there are a few ways to deal with the impact of the faulty genes. The most extreme solution is direct DNA editing to repair the mutation, while the treatment of symptoms with medication is the least invasive, though this comes with its own set of disadvantages. Antisense therapy keeps a middle ground here, by targeting the messenger RNA (mRNA) that forms the bridge between DNA and the translation into a functional protein by the ribosome.

In a recent study by [Olivia Kim-McManus] et al. antisense therapy with an allele-specific feature was demonstrated in two individuals with SCN2A mutations. These mutations had resulted in severe epilepsy and developmental disorders, due to how instrumental this gene is for normal functioning of the human central nervous system (CNS) where it regulates the initiation of action potentials.

Although SCN2A mutations are rarely inherited, for the approximately 1 in 80,000 affected the consequences can be quite dramatic. The two major types of mutations are classified as gain-of-function (GoF) and loss-of-function (LoF) with respectively hyper- and hyposensitivity of the resulting NA_v1.2 sodium channels.

This translates especially in the case of GoF mutations into various symptoms, ranging from mild to severe (daily) epileptic attacks starting as an infant, stalled neurodevelopment and various types of autism (ASD). Often sodium channel blockers are prescribed for the GoF cases to limit epileptic attacks.

Usually with the responsible mutations only a single copy of the gene is affected, so while regular antisense therapy could be used, this would risk also modifying the healthy SCN2A mRNA copy. To get around this, an individualized treatment was developed, targeting the allele with the mutated gene for the two patients in the study: 9- and 14-year old boys with severe developmental and epileptic encephalopathies (DEE) that had left them with daily seizures and despite sodium-channel blockers and other typical medications.

Study outcome of the 14-year old boy with DEE after ASO therapy. (Credit: Kim-McManus et al., Nature Medicine, 2026)

During the trial, the 9-year old boy received 12 doses over 24 months of antisense oligonucleotides (ASOs) adapted to his affected allele, allowing for the cessation of the anti-seizure medication phenytoin, with an overall reduction in seizures. In the case of the 14-year old boy 8 doses were administered over 16 months, resulting in an average of two seizures a day being reduced to zero.

Although the focus of the study was on treating these seizures, by addressing the underlying cause of faulty mRNA transcriptions, changes in the neurodevelopmental state could also be observed. In particular language and motor skills improved, with erratic and irritable behavior reducing. The by then 15-year year old boy was able to walk unassisted, showing clear progression from the previous infantile state.

The advantage of ASOs over typical anti-seizure medication is of course that it directly addresses the faulty mRNA and thus the resulting faulty sodium channels. Since ASOs tend to hang around in a cell for a considerable amount of time, they could be quite a viable alternative treatment even for less severe cases. Whether early application of individualized ASOs in affected infants could lead to a more or less normal neurodevelopment would also be an interesting study question.

Naturally, directly addressing the faulty gene or upregulating the healthy gene would be the ideal and permanent solution, with research here also underway in mice models with the use of CRISPR-based tools.

V Formation Flying Of Birds Is Explained By A Minimal Wake–Vortex Model

July 22, 2026 by Maya Posch 11 Comments

Although it’s commonly suspected that migratory birds fly in a ‘V’ formation due to this saving energy for the birds in the slipstream, understanding the exact aerodynamics behind this and how it affects the way that the birds use their wings to maintain this optimal pattern. After all, unlike airplanes and cars, our feathered avian dinosaur friends need to flap their wings if they want to have any chance of staving off plummeting back to Earth. Recent research by Brown University researchers now have provided a simulated model that answers many questions.

The major question was how this would work in the up- and down-wash zones created in this type of formation, with every bird following the lead bird dealing with the vortices created by the flapping of the wings of the bird before them. These wake vortices are quite complex, and thus required careful modelling to make sense of them.

As described in the paper by [Olivia Pomerenk] et al., the model is based on northern bald ibises, taking into account live-bird measurements for validation of the model. The main effect that can be observed is a reduced flapping amplitude, leading to an 11% energy savings for the birds in the leader’s wake.

The main advantage of having such a model is of course that it provides insight into the kinematic and aerodynamic mechanisms, meaning the ability to model virtual flocks of birds, predict the efficiency of specific in-flight configurations, and apply the lessons to swarms of drones, or whatever else we want to put in the air.

Counterfeit Retro Mainboards With Fake AGP Slots Are A Thing

July 21, 2026 by Maya Posch 29 Comments

Sometimes that retro gaming itch strikes, and you just have to source components for a Pentium 4 build, like [Computer Retro Bus] did recently. Unfortunately, along the way he learned that you can actually get counterfeit mainboards. Case in point the purported ‘Asrock P4i45GV’ that was purchased as the core of this Pentium 4 build, which turned out to have many issues that included a fake AGP slot.

The mainboard was bought off Facebook Marketplace, with the first sign of trouble being spotty GPU support for the AGP slot, and an inability to install a driver for a card that seemed to work. Following this, issues with the installed Soundblaster soundcard popped up, with the use of Windows ME as OS being of course a factor, but even ME is generally not this sketchy.

Warning on fake AGP slot on genuine Asrock mainboard. (Credit: The Retro Web)

At some point he decided to actually dig into this Socket 478 mainboard that he had purchased, only to find out that there was a reason why there were no real markings on it. After an image search it turned out to be a clone of the aforementioned Asrock mainboard, including the original’s ‘feature’ of connecting the ‘AGP’ slot to the PCI bus. This explained why only the AGP GPUs that are compatible with PCI worked with this mainboard, as it’s actually Asrock’s ‘AGI’ slot.

Effectively just a way to scam buyers into believing that they bought a mainboard with an AGP slot when it was just a regular PCI slot cosplaying as an AGP slot. This doesn’t just mean lower speeds and spotty support with AGP cards, but also also potentially dead GPUs, as this mainboard inherited the same 3.3V-only card support.

Unlike PCI slots that are keyed for 3.3/5V voltage support, AGP slots are keyed for either 3.3V or 1.5V, or no key for universal support. These ‘AGI’ slots are sadly keyed for 1.5V AGP cards and thus will expose 1.5V-only AGP cards to potentially fatal voltages.

On the bright side, these are at least genuinely old mainboards, using the same AGP-less Intel chipsets, made back in the day to sell to unsuspecting buyers. Clearly the pain that these fake boards as well as genuine Asrock boards that these ripped off caused back in the day continues in 2026. Caveat Emptor, as they say.

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Giving Resin 3D Printers Another Shot After Six Years

July 21, 2026 by Maya Posch 23 Comments

My initial experience with a 3D printer came in 2020, when I got access to a buddy’s Creality LD-002R SLA printer. This was one of those awkward transition phases for SLA printers, where inefficient RGB LCDs finally got replaced by monochrome LCD panels, thus massively reducing the required exposure time and increasing the LCD panel’s lifespan.

The closely related Creality LD-002H is a monochrome SLA printer, but as this wasn’t the one that this friend opted for we had to learn the ropes on this more old-school printer. In terms of specifications this meant a build volume of 119 mm x 65 mm x 160 mm to play with and a claimed 26.1 µm resolution. Despite some struggles along the way, this machine churned out impressively high levels of detail with whatever cheap resin we threw at it, and even the post-printing processing became easy once we added a flex plate to the build plate and tweaked the cleaning and curing steps.

Despite all these positives, we both drifted away from resin printing, mostly due to the still messy and smelly printing process. FDM printers seemed like a better deal, especially after said buddy got his mittens on a used IDEX FDM printer. I would eventually go through a rather loathsome Creality Ender V2 experience before ending up with my current-day Elegoo Neptune 4, and resin printing seemed to be a thing of the past for me. Until recently, that is.

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