How Gut Bacteria May Affect The Outcome Of Cancer Immunotherapy

April 22, 2026 by Maya Posch 2 Comments

In the ongoing development of cancer immunotherapy, as well as our still developing understanding of the human immune system, there’s always been a bit of massive elephant in the room. The thing about human bodies is that they’re not just human cells, but also consist of trillions of bacteria that mostly live in the intestines. What effect these bacteria have on the immune system’s functioning and from there on immunotherapies was recently investigated by [Tariq A. Najar] et al., with an article published in Nature.

The relevant topic here is that of antigenic mimicry, involving microbial antigens that resemble self-antigens. Since these self-antigens are a crucial aspect of both autoimmune diseases and cancer immunotherapy there is considerable room for interaction with their microbial mimics. Correspondingly these mimics can have considerable negative as well as positive implications, ranging from potentially triggering an autoimmune condition to hindering or boosting cancer immunotherapy.

In this study mice were used to investigate the effect of such microbial interference, in particular focusing on immune checkpoint blockade (ICB), which refers to negative feedback responses within the immune system that some cancers use to protect themselves. In some immunotherapy patients ICB inhibiting using e.g. anti programmed cell death protein (anti-PD-1) treatment does not provoke a response for some reason.

For the study mice had tumors implanted and the effect of a particular microbe (segmented filamentous bacteria, SFB) on it studied, with the presence of it markedly improving the response to anti-PD-1 treatment due to anti-gens expressed by SFB despite the large gut-skin distance. Whether in humans similar mechanisms play a similarly strong role remains to be investigated, but it offers renewed hope that cancer immunotherapies like CAR T-cell immunotherapy will one day make cancer an easily curable condition.

Repairing A Mercedes EQC 300 BEV Battery

April 22, 2026 by Maya Posch 14 Comments

When [OGS Mechanics] got a Mercedes EQC 300 battery-electric car in for repair, it was found to have a bit of a weird issue: after sitting in a garage for a while, its range on battery had suddenly reduced significantly without clear cause. Although the typical response here is to just mark the battery pack as ‘faulty’ and replace the whole unit, [OGS] decided to dig into the pack to see what was going on.

The short version is that this particular battery pack consists of two individual batteries, each with its own BMS, one of which had reported a condition to the master BMS that triggered the ‘replace battery module’ error observed with the scan tool. From this it could also be seen that the first battery was at a 10% state-of-charge (SoC), and the second at 95%, making them incredibly unbalanced. Unfortunately the dealer procedure to rebalance did not work here, with only the second battery wanting to charge even after draining both to the same initial level.

To diagnose the underlying issue in earnest required gently prying open the battery pack like a massive glued-shut smartphone. Going by the theory that it is a software glitch, since the first battery was still at a healthy voltage level, it was decided to manually charge it. With both batteries now fully charged, the BMS for the first battery was then removed to have its memory overwritten with that of a known good BMS module, clearing the ‘replace battery module’ error.

Although in the preview for the next video it’s hinted that there’s also an internal balancing issue in the first battery pack, this could be another symptom of its BMS glitching out. Either way, it would seem that BEVs battery modules are both heavily dependent on software, as well as afflicted by the same throw-away culture that has people just buying a new smartphone when the battery fails.

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The Electromechanical Computer Of The B-52’s Star Tracker

April 21, 2026 by Maya Posch 22 Comments

The Angle Computer of the B-52, opened. (Credit: Ken Shirriff)

In the ages before convenient global positioning satellites to query for one’s current location military aircraft required dedicated navigators in order to not get lost. This changed with increasing automation, including the arrival of increasingly more sophisticated electromechanical computers, such as the angle computer in the B-52 bomber’s star tracker that [Ken Shirriff] recently had a poke at.

We covered star trackers before, with this devices enabling the automation of celestial navigation. In effect, as long as you have a map of the visible stars and an accurate time source you will never get lost on Earth, or a few kilometers above its surface as the case may be.

The B-52’s Angle Computer is part of the Astro Compass, which is the star tracker device that locks onto a star and outputs a heading that’s accurate to a tenth of a degree, while also allowing for position to be calculated from it. Inside the device a lot of calculations are being performed as explained in the article, though the full equations are quite complex.

Not burdening the navigator of a B-52 with having to ogle stars themselves with an instrument and scribbling down calculations on paper is a good idea, of course. Instead the Angle Computer solves the navigational triangle mechanically, essentially by modelling the celestial sphere with a metal half-sphere. The solving is thus done using this physical representation, involving numerous gears and other parts that are detailed in the article.

In addition to the mechanical components there are of course the motors driving it, feedback mechanisms and ways to interface with the instruments. For the 1950s this was definitely the way to design a computer like this, but of course as semiconductor transistors swept the computing landscape, this marvel of engineering would before long find itself too replaced with a fully digital version.

Why Some S3 Videocards Have A Brightness Issue

April 21, 2026 by Maya Posch 8 Comments

Once a pioneer in videocards, S3’s legacy is today mostly found in details like texture compression as well as the strong presence of S3-branded videocards in the retro-computing world. There’s however a bit of a funny issue with some of these S3 cards in what is often called a ‘brightness bug’, but which as [Bits und Bolts] covers in a recent video was actually a hardware feature that we can once again blame composite video for.

This issue appears with AGP cards like the Trio 3D, Trio64 and ViRGE, where the brightness on the output signal is set too high, easily seen with the washed out look on boot, where especially on CRTs you’d expect to see the nice deep black background. Using an S3 Trio 3D 2X card that was saved from the e-waste pile this so-called Pedestal Bit responsible is investigated and tweaked to show what difference it makes.

At the core is adjusting the black level to make scanline changes easier to detect for TVs, which is no longer relevant for CRTs, LCDs, etc., while adjusting the brightness for one videocard in a system can cause issues elsewhere, such as when using said card alongside a 3dfx Voodoo II card or with inconsistent brightness levels inside 3D games.

Fortunately S3 provided in-depth datasheets on their chips, including how to address the responsible bit. After demonstrating the principle, the BIOS is then patched to set this Pedestal Bit to the value of 0 on boot, solving the issue once and for all.

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Growing Aluminium-Copper Alloy Crystals Using Hydrogen

April 20, 2026 by Maya Posch 2 Comments

Having molten aluminium interact with atmospheric water forms a source of hydrogen which can be rather problematic if you’re trying to cast aluminium parts. As the molten metal cools down, the dissolved hydrogen is forced out, creating bubbles and other flaws that make aluminium foundries rather upset. While you can inject inert gases to solve the problem, you can also lean into this issue to make some rather fascinating aluminium crystals and geodes, as [Electron Impressions] recently did.

The key here is to use a eutectic Al-Cu alloy at around 45% Cu by weight, as this alloy readily forms large crystals as it cools down. With hydrogen injected into the molten metal, this hydrogen forms large bubbles inside the cooling metal with crystals clearly visible.

A way to create proper geodes involves very slow cooling and pouring off the still molten metal before the eutectic point is reached. As can be seen in this video, this creates a rather impressive looking geode after it’s been smashed open. This also gives a good clue as to how these geological features form in nature, although one does not typically observe Al-Cu alloy geodes in the wild.

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Making The Most Pick-Proof Lock Yet

April 20, 2026 by Maya Posch 43 Comments

3D cutaway of the lock with the handle engaging the cog that rotates the mechanism. (Credit: Works By Design, YouTube)

Throughout the centuries the art of lock-making and lock-picking have been trapped in a constant struggle, with basic lock designs being replaced by ever more complex ones that seek to thwart any lockpicking attempts, as well as less gentle approaches. When it comes to the very common pin-and-tumbler lock design, the main issue here is that the keyway also provides direct access to the lock’s mechanism. This led [Works By Design] to brainstorm a lock design in which the keyway is hidden.

The ingenious part here is that because the actual key is rotated away after insertion, there is no clear path to the pins. This did require some creative thinking to have a somewhat traditional style key as well as a way to turn the internal mechanism so that the key would be pressed against the pins. Here inspiration was drawn from the switchable magnet mechanism as seen with e.g. magnetic bases. This ensures the key and key handle can be detached and attached quite firmly.

After many 3D printed prototypes, a metal version was CNCed and subjected to some early testing by a locksmith, who even with having seen the CAD model of the lock was stumped. With this initial result and some user feedback in the bag, it was time for large-scale testing with more lockpick enthusiasts, as there are many more ways to open a lock beyond pushing pins. That said, a mechanism was also added to the lock to prevent bumping attacks.

The next testers were found in the Lock Pickers United community, one of whom raised the issue of an impressioning attack. With a couple of test locks on their way to said lockpicking enthusiasts it’ll be exciting to see whether this new lock design will set the standard for future locks or not.

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DIY Nuclear Battery With PV Cells And Tritium

April 20, 2026 by Maya Posch 22 Comments

Nuclear batteries are pretty simple devices that are conceptually rather similar to photovoltaic (PV) solar, just using the radiation from a radioisotope rather than solar radiation. It’s also possible to make your own nuclear battery, with [Double M Innovations] putting together a version that uses standard PV cells combined with small tritium vials as radiation source.

The PV cells are the amorphous type, rated for 2.4 V, which means that they’re not too fussy about the exact wavelength at the cost of some general efficiency. You generally find these on solar-powered calculators for this reason. Meanwhile the tritium vials have an inner coating of phosphor so they glow. With a couple of these vials sandwiched in between two amorphous cells you thus have technically something that you could call a ‘nuclear battery’.

With an approximately 12 year half-life, tritium isn’t amazingly radioactive and thus the glow from the phosphor is also not really visible in daylight. With this DIY battery wrapped up in aluminium foil to cover it up fully, it does appear to generate some current in the nanoamp range, with a single-cell and series voltage of about 0.5 V.

A 170 VAC-rated capacitor is connected to collect some current over time, with just under 3 V measured after a night of charging. In how far the power comes from the phosphor and how much from sources like thermal radiation is hard to say in this setup. However, if you can match up the PV cell’s bandgap a bit more with the radiation source, you should be able to pull at least a few mW from a DIY nuclear battery, as seen with commercial examples.

This isn’t the first time we’ve seen this particular trick. A few years ago, a similar setup was used to power a handheld game, as long as you don’t mind waiting a few months for it to charge.

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