Intranasal Vaccines: A Potential Off-Ramp For Coronavirus Pandemics

September 29, 2022 by Maya Posch 54 Comments

An interesting and also annoying aspect about the human immune system is that it is not a neat, centralized system where you input an antigen pattern in one spot and suddenly every T and B lymphocyte in the body knows how to target an intruder. Generally, immunity stays confined to specific areas, such as the vascular and lymph system, as well as the intestinal and mucosal (nasal) parts of the body.

The result of this is that specific types of vaccines have a different effect, as is demonstrated quite succinctly with the polio vaccines. The main difference between the oral polio vaccine (OPV) and inactivated vaccine (injected polio vaccine, or IPV) is that the former uses a weakened virus that induces strong immunity in the intestines, something that the latter does not. The effect of this is that while both protect the individual, it does not affect the fecal-oral infection route of the polio virus and thus the community spread.

The best outcome for a vaccine is when it both protects the individual, while also preventing further infections as part of so-called sterilizing immunity. This latter property is what makes the OPV vaccine so attractive, as it prevents community spread, while IPV is sufficient later on, as part of routine vaccinations. The decision to use a vaccine like the OPV versus the IPV is one of the ways doctors can tune a population’s protection against a disease.

This is where the current batch of commonly used SARS-CoV-2 vaccines are showing a major issue, as they do not provide significant immunity in the nasal passage’s mucosal tissues, even though this is where the virus initially infects a host, as well as where it replicates and infects others from. Here intranasal vaccines may achieve what OPV did for polio.

Continue reading “Intranasal Vaccines: A Potential Off-Ramp For Coronavirus Pandemics” →

Self-Driving Laboratories Do Research On Autopilot

September 29, 2022 by Zoe Skyforest 16 Comments

Scientific research is a messy business. The road to learning new things and making discoveries is paved with hard labor, tough thinking, and plenty of dead ends. It’s a time-consuming, expensive endeavor, and for every success, there are thousands upon thousands of failures.

It’s a process so inefficient, you would think someone would have automated it already. The concept of the self-driving laboratory aims to do exactly that, and could revolutionize materials research in particular.

Continue reading “Self-Driving Laboratories Do Research On Autopilot” →

Mining And Refining: Sulfur

September 28, 2022 by Dan Maloney 23 Comments

When you think of the periodic table, some elements just have a vibe to them that’s completely unscientific, but nonetheless undeniable. Precious metals like gold and silver are obvious examples, associated as they always have been with the wealth of kings. Copper and iron are sturdy working-class metals, each worthy of having entire ages of human industry named after them, with silicon now forming the backbone of our current Information Age. Carbon builds up the chemistry of life itself and fuels almost all human endeavors, and none of us would get very far without oxygen.

But what about sulfur? Nobody seems to think much about poor sulfur, and when they do it tends to be derogatory. Sulfur puts the stink in rotten eggs, threatens us when it spews from the mouths of volcanoes, and can become a deadly threat when used to make gunpowder. Sulfur seems like something more associated with the noxious processes and bleak factories of the early Industrial Revolution, not a component of our modern, high-technology world.

And yet despite its malodorous and low-tech reputation, there are actually few industrial processes that don’t depend on massive amounts of sulfur in some way. Sulfur is a critical ingredient in processes that form the foundation of almost all industry, so its production is usually a matter of national and economic security, which is odd considering that nearly all the sulfur we use is recovered from the waste of other industrial processes.

Continue reading “Mining And Refining: Sulfur” →

Probably The Simplest Radiation Detector You Already Own

September 26, 2022 by Jenny List 78 Comments

Over the years we’ve featured quite a few radiatioactivity detectors, which usually include a Geiger-Muller tube, or perhaps a large-area photodiode. But in the event of radiation exposure from a nuclear attack, how does the man in the street gauge the exposure without owning a dedicated instrument? This was a question of note at the height of the Cold War, and it’s one that [Dr. Marshall Brucer] answered in a 1962 paper entitled “When Do You Leave A Fallout Shelter“. The full paper is behind a paywall but the part we’re interested in is on the freely available first page.

Dr. Brucer‘s detector is simplicity itself, and it relies on the erosion of a static electric charge by radiation. Should you rub a plastic comb in your hair it will accumulate enough charge to pick up a small piece of paper, and under normal background radiation the charge will ebb away such that it will drop the piece of paper after about 15 seconds. His calculation is that once the field reaches around 10 roentgens per hour it will be enough to erase the charge and drop the paper immediately. There’s a comtemporary newspaper report (Page 7, just to the left of the large advertisment) which tells the reader that since the exposure limit is 100 roentgens (one sievert), this test failing indicates that they have nine hours to create a better shelter. For obvious reasons we can’t test this at the Hackaday bench, but those of us who remember the days when such topics were a real concern will be searching for a handy comb anyway.

Thanks [Victor Matthew] for the tip.

Overhead satellite view of a coal-fired power plant next to a heat map showing the suitability of terrain in the region for siting a nuclear power plant

Coal To Nuclear Transition To Decarbonize The Grid

September 22, 2022 by Navarre Bartz 170 Comments

We love big projects here at Hackaday, and one of the biggest underway is the decarbonization of the electric grid. The US Department of Energy (DOE) recently published a report (PDF) on how placing nuclear reactors on coal plant sites in the US could help us get closer to the zero carbon grid of our dreams.

After evaluating both operating and recently retired coal-fired plants in the US, the researchers determined that around 80% of medium and large coal plants would be good candidates for coal to nuclear (C2N). Up to 263 GWe could be installed at over 315 different sites around the country which would be more than the 145 GWe expected to go offline as the remaining coal plants in the country shut down. Siting nuclear reactors at these existing sites could reduce installation costs 15-35% while also providing jobs for workers in the area who might otherwise be displaced when the coal plants shut down. Local greenhouse gas emissions (GHG) could drop up to 86% along with a significant drop in other air pollutants which would be another win for the fenceline communities living and working around these coal plants.

Nuclear power is certainly not without its drawbacks, but new reactor designs like TerraPower’s Natrium promise lower costs than current light water reactor designs while also being able to reuse the spent fuel from our current nuclear fleet. TerraPower is developing the first C2N project in the US at the Naughton Power Plant in Kemmerer, Wyoming.

We’ve recently covered Cogeneration and District Heating which would get a boost from more nuclear power, but, if that’s too grounded for you, might we suggest Space-Based Solar Power?

IGY: The Year We All Got Along

September 20, 2022 by Al Williams 24 Comments

If you are a Steely Dan fan, you might know the Donald Fagen song, “IGY.” In it, Fagen sings about a rosy future with high-speed undersea rail, solar power, giant computers making life better, and spandex jackets. Since that song was on the 1982 album Nightfly, it is already too old for some people to remember, but the title goes back even further: the International Geophysical Year which was actually a little longer than a year in 1957 and 1958. The year was a concerted effort by 67 countries to further mankind’s knowledge of the Earth. It was successful, and was big news in its day, although not much remembered now.

The real origin dates back to even earlier. In 1882 and 1932 there were International Polar Years dedicated to researching the polar regions of the Earth. In a way, it makes sense to do this. Why should 60 or more countries each mount difficult, dangerous, and expensive expeditions to such a hostile environment? However, instead of a third polar year, James Van Allen (who has a famous belt) and some other scientists felt that advances in many fields made it the right time to study geophysics. From the scientific point of view, the IGY coincided with the solar activity cycle maximum. But there were other forces at play, too.

Continue reading “IGY: The Year We All Got Along” →

Multi-Stage Ion Thruster Holds Exciting Promise

September 19, 2022 by Tom Nardi 56 Comments

Anyone who’s looked into high-voltage experiments is likely familiar with ion lifters — spindly contraptions made of wire and aluminum foil that are able to float above the workbench on a column of ionized air. It’s an impressive trick that’s been around since the 1950s, but the concept has yet to show any practical application as the thrust generated isn’t nearly enough to lift a more substantial vehicle.

It’s a bit early to suggest that [Jay Bowles] of Plasma Channel has finally found the solution to this fundamental shortcoming of electrostatic propulsion, but his recently completed multi-stage ion thruster certainly represents something of a generational leap for the technology. By combining multiple pairs of electrodes and experimentally determining the optimal values for their spacing and operational voltage, he’s been able to achieve a sustained exhaust velocity of 2.3 meters per second.

Dry ice was used to visualize airflow through the thruster.

While most ion thrusters are lucky to get a piece of paper fluttering for their trouble, [Jay] demonstrates his creation blowing out candles at a distance of a meter or more. But perhaps the most impressive quality of this build is the sound — unlike most of the experimental ion thrusters we’ve seen, the air flowing through this contraption actually makes an audible roaring sound. When the 45 kilovolt supply voltage kicks in it sounds like a hair drier, except here there’s no moving parts involved.

In addition to providing graphs that show how air velocity was impacted by input voltage and the number and spacing of the electrode pairs, [Jay] also pops the thruster on a scale to show that there is indeed a measurable thrust being produced. Admittedly the 22 grams of thrust being generated isn’t much compared to the contraption’s own mass of 490 grams, but in the world of electrostatic propulsion, those are pretty impressive numbers.

[Jay] says he has some improvements in mind that he believes will significantly improve the device’s performance as he works towards his ultimate goal of actually flying an ion-propelled aircraft. We saw MIT do it back in 2018, and it would be great to see an individual experimenter pull off a similar feat. Obviously, there’s still a long way to go before this thing takes to the skies, but if anyone can pull it off, it’s [Jay Bowles].

Continue reading “Multi-Stage Ion Thruster Holds Exciting Promise” →