A human hand in a latex glove holds a test tube filled with red liquid labeled H5N1. In the background is an out of focus image of a chicken.

Preparing For The Next Pandemic

While the COVID-19 pandemic wasn’t an experience anyone wants to repeat, infections disease experts like [Dr. Pardis Sabeti] are looking at what we can do to prepare for the next one.

While the next pandemic could potentially be anything, there are a few high profile candidates, and bird flu (H5N1) is at the top of the list. With birds all over the world carrying the infection and the prevalence in poultry and now dairy agriculture operations, the possibility for cross-species infection is higher than for most other diseases out there, particularly anything with an up to 60% fatality rate. Only one of the 70 people in the US who have contracted H5N1 recently have died, and exposures have been mostly in dairy and poultry workers. Scientists have yet to determine why cases in the US have been less severe.

To prevent an H5N1 pandemic before it reaches the level of COVID and ensure its reach is limited like earlier bird and swine flu variants, contact tracing of humans and cattle as well as offering existing H5N1 vaccines to vulnerable populations like those poultry and dairy workers would be a good first line of defense. So far, it doesn’t seem transmissible human-to-human, but more and more cases increase the likelihood it could gain this mutation. Keeping current cases from increasing, improving our science outreach, and continuing to fund scientists working on this disease are our best bets to keep it from taking off like a meme stock.

Whatever the next pandemic turns out to be, smartwatches could help flatten the curve and surely hackers will rise to the occasion to fill in the gaps where traditional infrastructure fails again.

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Bone Filament, For Printing Practice Bones

Of course there is bone-simulation filament on the market. What’s fun about this Reddit thread is all of the semi-macabre concerns of surgeons who are worried about its properties matching the real thing to make practice rigs for difficult surgeries. We were initially creeped out by the idea, but now that we think about it, it’s entirely reassuring that surgeons have the best tools available for them to prepare, so why not 3D prints of the actual patient’s bones?

[PectusSurgeon] says that the important characteristics were that it doesn’t melt under the bone saw and is mechanically similar, but also that it looks right under x-ray, for fluorscopic surgery training. But at $100 per spool, you would be forgiven for looking around for substitutes. [ghostofwinter88] chimes in saying that their lab used a high-wood-content PLA, but couldn’t say much more, and then got into a discussion of how different bones feel under the saw, before concluding that they eventually chose resin.

Of course, Reddit being Reddit, the best part of the thread is the bad jokes. “Plastic surgery” and “my insurance wouldn’t cover gyroid infill” and so on. We won’t spoil it all for you, so enjoy.

When we first read “printing bones”, we didn’t know if they were discussing making replacement bones, or printing using actual bones in the mix. (Of course we’ve covered both before. This is Hackaday.)

Thanks [JohnU] for the tip!

The Rise Of The Disappearing Polymorphs

Science and engineering usually create consistent results. Generally, when you figure out how to make something, you can repeat that at will to make more of something. But what if, one day, you ran the same process, and got different results? You double-checked, and triple-checked, and you kept ending up with a different end product instead?

Perhaps it wasn’t the process that changed, but the environment? Or physics itself? Enter the scary world of disappearing polymorphs.

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Slime Mold-Powered Smart Watches See Humans Fall In Love With The Goo

Humans are very good at anthropomorphising things. That is, giving them human characteristics, like ourselves. We do it with animals—see just about any cartoon—and we even do it with our own planet—see Mother Nature. But we often extend that courtesy even further, giving names to our cars and putting faces on our computers as well.

A recent study has borne this out in amusing fashion. Researchers at the University of Chicago found that human attitudes towards a device can change if they are required to take actions to look after it. Enter the slime mold smartwatch, and a gooey, heartwarming story of love and care between human and machine, mediated by mold.

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British Hospital Blasts Through Waiting Lists By Slashing Surgeon Downtime

It feels like it doesn’t matter where you go, health systems are struggling. In the US, just about any procedure is super expensive. In the UK and Australia, waiting lists extend far into the future and patients are left sitting in ambulances as hospitals lack capacity. In France, staff shortages rage furiously, frustrating operations.

It might seem like hope is fruitless and there is little that can be done. But amidst this horrid backdrop, one London hospital is finding some serious gains with some neat optimizations to the way it handles surgery, as The Times reports.

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Radioactive Water Was Once A (Horrifying) Health Fad

Take a little time to watch the history of Radithor, a presentation by [Adam Blumenberg] into a quack medicine that was exactly what it said on the label: distilled water containing around 2 micrograms of radium in each bottle (yes, that’s a lot.) It’s fascinatingly well-researched, and goes into the technology and societal environment surrounding such a product, which helped play a starring role in the eventual Food, Drug, and Cosmetic Act of 1938. You can watch the whole presentation in the video, embedded below the break. Continue reading “Radioactive Water Was Once A (Horrifying) Health Fad”

MIT Engineers Pioneer Cost-Effective Protein Purification For Cheaper Drugs

There are a wide variety of protein-based drugs that are used to treat various serious conditions. Insulin is perhaps the most well-known example, which is used for life-saving treatments for diabetes. New antibody treatments also fall into this category, as do various vaccines.

A significant cost element in the production of these treatments is the purification step, wherein the desired protein is separated from the contents of the bioreactor it was produced in. A new nanotech discovery from MIT could revolutionize this area, making these drugs cheaper and easier to produce.

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