When we took a biology lab, you had to use a mouth pipette to transfer liquids around. That always seemed odd to use your mouth to pick up something that could be dangerous. It’s also not very efficient. A modern lab will use a liquid handling robot, but these aren’t exactly cheap. Sometimes these are called pipettors and even a used one on eBay will set you back an average of $1,000 — and many of them much more than that. Now there’s an open source alternative, OpenLH, that can be built for under $1,000 that leverages an open source robot arm. You can find a video about the system below.
The robot arm, a uArm Swift Pro, is the bulk of the cost. The Pro can also operate as a 3D printer or a laser engraver with a little work. In fact, we wondered if you could use the arm to make a 3D printer and then print the parts you need to convert it to a liquid handler. Seems like it should work.
Continue reading “OpenLH: Automating Biology for Everyone”
The ocean is a hostile environment for man-made equipment, no matter its purpose. Whether commercial fishing, scientific research, or military operations, salt water is constantly working to break them all down. The ocean is also home to organisms well-adapted to their environment so DARPA is curious if we can leverage their innate ability to survive. The Persistent Aquatic Living Sensors (yes, our ocean PALS) program is asking for creative ideas on how to use sea life to monitor ocean activity.
Its basic idea is simple: everyday business of life in the ocean are occasionally interrupted by a ship, a submarine, or some other human activity. If this interruption can be inferred from sea life response, getting that data could be much less expensive than building sensors to monitor such activity directly. Everyone who applies to this research program will have the chance to present their own ideas on how to turn this idea into reality.
The program announced it will “study natural and modified organisms” (emphasis ours.) Keeping an open mind to bio-engineering ideas will be interesting, but adding biohacking to the equation also adds to the list of potential problems. While PALS will keep its research within contained facilities, any future military deployment obviously will not. Successful developments in this area will certainly raise eyebrows and face resistance against moving beyond the lab.
But such possibilities are still far away in a future that many never arrive, as is common with DARPA initiatives. Very recently we talked about their interest in brain stimulation and we’ve been fascinated by many DARPA initiatives before that. If PALS takes off, their living sensor nodes might end up face to face with the open-source underwater glider project that won this year’s Hackaday prize.
So [DARPA] wants to start hacking human brains, With the help of the biomedical device center at the university of Texas in Dallas. This does sound a bit crazy but DARPA does crazy. Conspiracy theorists are going to have a field day with this one.
The initial plans to turn us all into mindless zombies seem to be shelved for now, however they are working on what they call Targeted Neuroplasticity Training (TNT), which they explain means using the body’s nervous system to enhance and speed up the learning process. This could be achieved by using a process known as ‘synaptic plasticity‘ which opens and closes the brains synapses with electrical stimulation. They hope that by tuning the neural networks responsible for cognitive function it will enhance learning. Let’s just hope they don’t turn any humans into DARPA falling robots.
CRISPR is the new darling of the genetics world, because it allows you to easily edit DNA. It is far more effective than previous techniques, being both precise and relatively easy to use. According to this IndieGoGo project, it is coming to your home lab soon. Genetic researchers love Clustered Regularly Interspaced Short Palindromic Repeats (CRISPR) because it allows you to very precisely edit a DNA strand. Using a protein called CAS9, CRISPR can find a very specific sequence in a DNA sequence and cut it. It occurs naturally in cells as part of the immune system: by finding and remembering parts of virus DNA, a cell can recognize and attack it when infected. For the genetics researcher, this allows them to insert new DNA sequences at specific points in the genes of any living cell.
Continue reading “IndieGoGo Project Offers DNA Editing For The Home”