Implant Fights Diabetes By Making Insulin And Oxygen

October 10, 2023 by Dan Maloney 13 Comments

Type 1 diabetes remains a problem despite having an apparently simple solution: since T1D patients have lost the cells that produce insulin, it should be possible to transplant those cells into their bodies and restore normal function. Unfortunately, it’s not actually that simple, and it’s all thanks to the immune system, which would attack and destroy transplanted pancreas cells, whether from a donor or grown from the patient’s own stem cells.

That may be changing, though, at least if this implantable insulin-producing bioreactor proves successful. The device comes from MIT’s Department of Chemical Engineering, and like earlier implants, it relies on encapsulating islet cells, which are the insulin-producing cells within the pancreas, inside a semipermeable membrane. This allows the insulin they produce to diffuse out into the blood, and for glucose, which controls insulin production in islet cells, to diffuse in. The problem with this arrangement is that the resource-intensive islet cells are starved of oxygen inside their capsule, which is obviously a problem for the viability of the implant.

The solution: electrolysis. The O₂-Macrodevice, as the implant is called, uses a tiny power-harvesting circuit to generate oxygen for the islet cells directly from the patient’s own interstitial water. The circuit applies a current across a proton-exchange membrane, which breaks water molecules into molecular oxygen for the islet cells. The hydrogen is said to diffuse harmlessly away; it seems like that might cause an acid-base imbalance locally, but there are plenty of metabolic pathways to take care of that sort of thing.

The implant looks promising; it kept the blood glucose levels of diabetic mice under control, while mice who received an implant with the oxygen-generating cell disabled started getting hyperglycemic after two weeks. What’s really intriguing is that the study authors seem to be thinking ahead to commercial production, since they show various methods for mass production of the cell chamber from standard 150-mm silicon wafers using photolithography.

Type 1 diabetics have been down the “artificial pancreas” road before, so a wait-and-see approach is clearly wise here. But it looks like treating diabetes less like a medical problem and more like an engineering problem might just pay dividends.

Autonomous Wheelchair Lets Jetson Do The Driving

October 4, 2023 by Tom Nardi 8 Comments

Compared to their manual counterparts, electric wheelchairs are far less demanding to operate, as the user doesn’t need to have upper body strength normally required to turn the wheels. But even a motorized wheelchair needs some kind of input from the user to control it, which still may pose a considerable challenge depending on the individual’s specific abilities.

Hoping to improve on the situation, [Kabilan KB] has developed a self-driving electric wheelchair that can navigate around obstacles by feeding the output of an Intel RealSense Depth Camera and LiDAR module into a Jetson Nano Developer Kit running OpenCV. To control the actual motors, the Jetson is connected to an Arduino which in turn is wired into a common L298N motor driver board.

As [Kabilan] explains on the NVIDIA Blog, he specifically chose off-the-shelf components and the most affordable electric wheelchair he could find to bring the total cost of the project as low as possible. An undergraduate from the Karunya Institute of Technology and Sciences in Coimbatore, India, he notes that this sort of assistive technology is usually only available to more affluent patients. With his cost-saving measures, he hopes to address that imbalance.

While automatic obstacle avoidance would already be a big help for many users, [Kabilan] imagines improved software taking things a step further. For example, a user could simply press a button to indicate which room of the house they want to move to, and the chair could drive itself there automatically. With increasingly powerful single-board computers and the state of open source self-driving technology steadily improving, it’s not hard to imagine a future where this kind of technology is commonplace.

ARPA-H Moonshot Project Aims To Enable 3D Printing Of Human Organs

October 4, 2023 by Maya Posch 9 Comments

The field of therapeutic cloning has long sought to provide a way to create replacement organs and tissues from a patient’s own cells, with the most recent boost coming from the US Advanced Research Projects Agency for Health (ARPA-H) and a large federal contract awarded to Stanford University.

Patients on the organ donation waiting list in the US (Source: HRSA)

The creatively named Health Enabling Advancements through Regenerative Tissue Printing (HEART) project entails a 26.3 million USD grant that will be used to create a functioning bioprinter backed by a bank of bioreactors. Each bioreactor will cultivate a specific type of cell, which will then be ‘printed’ in its proper place to gradually build up the target organ or tissue. The project’s five year goal is the printing of a fully functioning human heart and implanting it into a pig.

Assuming this is successful, the general procedure can then be refined to allow for testing with human patients, as well as the bioprinting of not just hearts, but also lungs, kidneys and much more. The lead investigator at Stanford University, [Mark Skylar-Scott], cautions that use with human patients is likely to be still decades off. But the lifesaving potential of this technology, once matured, is staggering. This is highlighted by data from the US HRSA, with over 42,000 transplants in 2022 in the US alone, with over a hundred-thousand patients waiting and 17 people who die each day before an organ becomes available.

Bioadhesive Polymer Semiconductors For In-Vivo Sensors

October 3, 2023 by Maya Posch 2 Comments

What do you do when you want to stick an electrode or even an couple of sensors to an internal organ, such as a heart? Generally you’d use some kind of special adhesive, or sutures to ensure that the item remains firmly in place and doesn’t migrate to somewhere else within the chest cavity or among the intestines. According to a new study (press release) by Nan Li and colleagues in Science there may however be a more elegant method, using bioadhesive polymers.

The double-network copolymer is designed so that once put in the desired location it soaks up moisture and provides a dry interface for its bioadhesive properties. In addition, the resulting material is electrically conductive, with a measured charge-carrier mobility of ~1 square centimeter per volt per second.

Using thus manufactured electrodes were applied to both an isolated rat heart and in vivo rat muscles to measure electrical currents produced by each respective tissue type. The authors of the study envision that using this technology more complicated interfaces and sensors can be developed that would interface directly with organs and related. The claimed biocompatibility would also allow for such devices to be left in-situ for extended periods of time, which could be a boon for a wide range of medical conditions where continuous monitoring is a crucial element.

Dr. Niels Olson uses the Augmented Reality Microscope. (Credit: US Department of Defense)

Google’s Augmented Reality Microscope Might Help Diagnose Cancer

October 1, 2023 by Maya Posch 10 Comments

Despite recent advances in diagnosing cancer, many cases are still diagnosed using biopsies and analyzing thin slices of tissue underneath a microscope. Properly analyzing these tissue sample slides requires highly experienced and skilled pathologists, and remains subject to some level of bias. In 2018 Google announced a convolutional neural network (CNN) based system which they call the Augmented Reality Microscope (ARM), which would use deep learning and augmented reality (AR) to assist a pathologist with the diagnosis of a tissue sample. A 2022 study in the Journal of Pathology Informatics by David Jin and colleagues (CNBC article) details how well this system performs in ongoing tests.

For this particular study, the LYmph Node Assistant (LYNA) model was investigated, which as the name suggests targets detecting cancer metastases within lymph node biopsies. The basic ARM setup is described on the Google Health GitHub page, which contains all of the required software, except for the models which are available on request. The ARM system is fitted around an existing medical-grade microscope, with a camera feeding the CNN model with the input data, and any relevant outputs from the model are overlaid on the image that the pathologist is observing (the AR part).

Although the study authors noted that they saw potential in the technology, as with most CNN-based systems a lot depends on how well the training data set was annotated. When a grouping of tissue including cancerous growth was marked too broadly, this could cause the model to draw an improper conclusion. This makes a lot of sense when one considers that this system essentially plays ‘cat or bread’, except with cancer.

These gotchas with recognizing legitimate cancer cases are why the study authors see it mostly as a useful tool for a pathologist. One of the authors, Dr. Niels Olsen, notes that back when he was stationed at the naval base in Guam, he would have liked to have a system like ARM to provide him as one of the two pathologists on the island with an easy source of a second opinion.

(Heading image: Dr. Niels Olson uses the Augmented Reality Microscope. (Credit: US Department of Defense) )

Inverse Vaccines Could Help Treat Autoimmune Conditions

September 25, 2023 by Lewin Day 78 Comments

Autoimmune diseases occur when the immune system starts attacking the body’s own cells. They can cause a wide range of deleterious symptoms that greatly reduce a patient’s quality of life. Treatments often involve globally suppressing the immune system, which can lead to a host of undesirable side effects.

However, researchers at the University of Chicago might have found a workaround by tapping into the body’s own control mechanisms. It may be possible to hack the immune system and change its targeting without disabling it entirely. The new technique of creating “inverse vaccines” could revolutionize the treatment of autoimmune conditions.

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Bespoke Implants Are Real—if You Put In The Time

September 6, 2023 by Brian McEvoy 23 Comments

A subset of hackers have RFID implants, but there is a limited catalog. When [Miana] looked for a device that would open a secure door at her work, she did not find the implant she needed, even though the lock was susceptible to cloned-chip attacks. Since no one made the implant, she set herself to the task. [Miana] is no stranger to implants, with 26 at the time of her talk at DEFCON31, including a couple of custom glowing ones, but this was her first venture into electronic implants. Or electronics at all. The full video after the break describes the important terms.

The PCB antenna in an RFID circuit must be accurately tuned, which is this project’s crux. Simulators exist to design and test virtual antennas, but they are priced for corporations, not individuals. Even with simulators, you have to know the specifics of your chip, and [Miana] could not buy the bare chips or find a datasheet. She bought a pack of iCLASS cards from the manufacturer and dissolved the PVC with acetone to measure the chip’s capacitance. Later, she found the datasheet and confirmed her readings. There are calculators in lieu of a simulator, so there was enough information to design a PCB and place an order.

The first batch of units can only trigger the base station from one position. To make the second version, [Miana] bought a Vector Network Analyzer to see which frequency the chip and antenna resonated. The solution to making adjustments after printing is to add a capacitor to the circuit, and its size will tune the system. The updated design works so a populated board is coated and implanted, and you can see an animated loop of [Miana] opening the lock with her bare hand.

Biohacking can be anything from improving how we read our heart rate to implanting a Raspberry Pi.

Continue reading “Bespoke Implants Are Real—if You Put In The Time” →