biohacking

48 Articles

Ctrl-X, Ctrl-V For DNA

September 20, 2015 by 23 Comments

Once upon a time, the aspiring nerdling’s gift of choice was the Gilbert chemistry set. Its tiny vials of reagents, rack of test tubes, and instruction book promised endless intellectual stimulation and the possibility of stink bombs on demand. Now a new genetic engineering lab-in-a-box Kickstarter, with all the tools and materials needed to create your own transgenic organisms, may help the young biohacker’s dreams come true.

The Kickstarter has been wildly successful. The initial goal was $1200AUD was met in a day, and currently stands at almost $6200AUD. Despite that success, color me skeptical on this one. Having done way more than my fair share of gene splicing, there seem to be a few critical gaps in this kit. For example, the list of materials for the full kit includes BL21 competent E. coli as the host strain. Those cells are designed to become porous to extracellular DNA when treated with calcium chloride and provided with a heat shock of 42°C. At a minimum I’d think they’d include a thermometer so you can control the heat shock process. Plenty of other steps also need fairly precise incubations, like the digestion and ligation steps needed to get your gene into the host. And exactly what technique you’d be using to harvest DNA from the animal, plant or fungal cells is unclear; the fact that most of the techniques for doing so require special techniques leads me to believe there’s a lot less here than meets the eye.

To be fair, I’ve been off the lab bench for the better part of two decades, and the state of the art has no doubt advanced in that time. There could very well be techniques I’m not familiar with that make the various steps needed to transform a bacterial culture with foreign DNA trivial. It could also be the case that the techniques I used in the lab were optimized for yield and for precise data, while the GlowGene kit provides the materials to get a “good enough” result. I hope so, because a kit like this could really expand the horizons of hackerdom and start getting the biohacking movement going.

[Thanks, Michael!]

The Biohacking Movement And Open Source Insulin

July 30, 2015 by 123 Comments

In March of 2014, I knew my eight year old daughter was sick. Once borderline overweight, she was now skeletally thin and fading away from us. A pre-dawn ambulance ride to the hospital gave us the devastating news – our daughter had Type 1 diabetes, and would be dependent on insulin injections for the rest of her life.

This news hit me particularly hard. I’ve always been a preparedness-minded kind of guy, and I’ve worked to free myself and my family from as many of the systems of support as possible. As I sat in the dark of the Pediatric ICU watching my daughter slowly come back to us, I contemplated how tied to the medical system I had just become. She was going to need a constant supply of expensive insulin, doled out by a medical insurance system that doesn’t understand that a 90-day supply of life-saving medicine is a joke to a guy who stocks a year supply of toilet paper. Plus I had recently read an apocalyptic novel where a father watches his 12-year old diabetic daughter slip into a coma as the last of her now-unobtainable insulin went bad in an off-grid world. I swore to myself that I’d never let this happen, and set about trying to find ways to make my own insulin, just in case.

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Mediated Matter At The MIT Media Lab

March 27, 2015 by 17 Comments

Few things have managed to capture the imagination of hackers and engineers around the world the way Synthetic Biology did over the last couple of years. The promise of “applying engineering principles to designing new biological devices and systems” just seemed way too sci-fi to missed out on, and everyone jumped on the bandwagon. All of a sudden, the field which used to be restricted to traditional research organizations and startups found itself crowded with all sorts of enthusiasts, biohackers, and weirdos alike. Competitions such as the International Genetically Engineered Machine (iGEM) paved the way, and the emergence of community spaces like GenSpace and BioCurious finally made DNA experimentation accessible to anyone who dares to try. As it often happens, the Sci-Fi itself did not go untouched, and a whole new genre called “Biopunk” emerged, further fueling people’s imagination and extrapolating worlds to come.

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25th Chaos Communication Congress Schedule

November 24, 2008 by 7 Comments

The team behind 25C3 has published the first draft of this year’s schedule. The annual Chaos Communication Congress is happening December 27th to 30th in Berlin, Germany. There are plenty of interesting talks already in place. We’re spotting things we want to attend already: The conference starts off with how to solar power your gear, which is followed by open source power line communication. A TOR-based VPN, an open source BIOS, rapid prototyping, holographic techniques, and running your own GSM network are on the bill too.

We’ll have at least three Hack a Day contributors in attendance. Last year featured two of our favorite conference talks: [Drew Endy]’s Biohacking and the MiFare crypto1 RFID crack. We hope to see you there.

25C3: Nothing To Hide Announced

August 16, 2008 by 7 Comments


Germany’s Chaos Computer Club has announced the theme for their annual Chaos Communication Congress: “Nothing to hide“. Like last year’s “Full steam ahead!“, it’s open to many interpretations. People striking down privacy laws often say citizens shouldn’t mind since they have “Nothing to hide”. The phrase is also connected to the inability to hide data, as the CCC demonstrated this year by publishing the German Home Secretary’s fingerprint. On a more positive side, “Nothing to hide” is also about the free exchange of information that happens at hacker conventions. The Congress is in its 25th year and promises to be as good as ever. At last year’s 24C3, we saw great talks like [Drew Endy]’s biohacking talk and the original MiFare crypto presentation. 25C3 will be held in Berlin December 27th to 30th. The wiki is already up and they’ve published a call for participation, if you’re interested.

24C3 Hacking DNA

January 5, 2008 by 28 Comments

[Drew Endy]’s Programming DNA talk was by far the most interesting talk we saw at Chaos Communication Congress. No, DNA doesn’t have much to do with computers, but he points out that hacking principles can be applied just the same. Right now engineers are reversing genetic code and compiling building blocks for creating completely arbitrary organisms. This talk was designed to bootstrap the hacking community so that we can start using and contributing standard biological parts to an open source collection of genetic functions.

You should definitely watch the video to get a good idea of where biohacking is at today. You can find a higher quality version of the video in the archives.