mRNA

3 Articles

Antiviral PPE For The Next Pandemic

August 19, 2025 by 35 Comments

In what sounds like the plot from a sci-fi movie, scientists have isolated an incredibly rare immune mutation to create a universal antiviral treatment.

Only present in a few dozen people worldwide, ISG15 immunodeficiency causes people to be more susceptible to certain bacterial illnesses, but it also grants the people with this condition immunity to known viruses. Researchers think that the constant, mild inflammation these individuals experience is at the root of the immunoresponse.

Where things get really interesting is how the researchers have found a way to stimulate protein production of the most beneficial 10 proteins of the 60 created by the natural mutation using 10 mRNA sequences inside a lipid nanoparticle. Lead researcher [Dusan Bogunovic] says “we have yet to find a virus that can break through the therapy’s defenses.” Researchers hope the treatment can be administered to first responders as a sort of biological Personal protective equipment (PPE) against the next pandemic since it would likely work against unknown viruses before new targeted vaccines could be developed.

Hamsters and mice were given this treatment via nasal drip, but how about intranasal vaccines when it comes time for human trials? If you want a short history of viruses or to learn how smartwatches could help flatten the curve for the next pandemic, we’ve got you covered.

Retrotechtacular: Understanding Protein Synthesis Through Interpretive Dance

August 1, 2021 by 8 Comments

With the principles of molecular biology very much in the zeitgeist these days, we thought it would be handy to provide some sort of visual aid to help our readers understand the complex molecular machines at work deep within each cell of the body. And despite appearances, this film using interpretive dance to explain protein synthesis will teach you everything you need to know.

Now, there are those who go on and on about the weirdness of the 1960s, but as this 1971 film from Stanford shows, the 60s were just a warm-up act for the really weird stuff. The film is a study in contrasts, with the setup being provided by the decidedly un-groovy Paul Berg, a professor of biochemistry who would share the 1980 Nobel Prize in Medicine for his contributions to nucleic acid research. His short sleeves and skinny tie stand in stark contrast to the writhing mass of students capering about on a grassy field, acting out the various macromolecules involved in protein synthesis. Two groups form the subunits of the ribosome, a chain of ballon-headed students act as the messenger RNA (mRNA) that codes for a protein, and little groups standing in for the transfer RNA (tRNA) molecules that carry the amino acids float in and out of the process.

The level of detail, at least as it was understood in 1971, is impressively complete, with soloists representing things like T-factor and the energy-carrying molecule GTP. And while we especially like the puff of smoke representing GTP’s energy transfer, we strongly suspect a lot of other smoke went into this production.

Kitsch aside, and with apologies to Lewis Carroll and his Jabberwock, you’ll be hard-pressed to find a modern animation that captures the process better. True, a more traditional animation might make the mechanistic aspects of translation clearer, but the mimsy gyre and gimble of this dance really emphasize the role random Brownian motion plays in macromolecular processes. And you’ll never see the term “tRNA” and not be able to think of this film.

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RNA Therapeutics And Fighting Diseases By Working With The Immune System

July 26, 2021 by 75 Comments

Before the SARS-CoV-2 pandemic took hold, few people were aware of the existence of mRNA vaccines. Yet after months of vaccinations from Moderna and BioNTech and clear indications of robust protection to millions of people, it now seems hard to imagine a world without mRNA vaccine technology, especially as more traditional vaccines seem to falter against the new COVID-19 variants and the ravages of so-called ‘Long COVID’ become more apparent.

Yet, it wasn’t that long ago that Moderna and BioNTech were merely a bunch of start-ups, trying to develop profitable therapies for a variety of diseases, using the brand-new and largely unproven field of RNA therapeutics. Although the use of mRNA in particular for treatments has been investigated since 1989, even as recently as 2017 there were still many questions about safe and effective ways to deliver mRNA into cells, as per Khalid A. Hajj et al.

Clearly those issues have been resolved now in 2021, which makes one wonder about the other exciting possibilities that mRNA delivery offers, from vaccines for malaria, cancer, HIV, as well as curing autoimmune diseases. How did the field of mRNA vaccines develop so quickly, and what can we expect to see the coming years?

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