Soft Robotic System For In Situ 3D Bioprinting And Endoscopic Surgery

The progress of medical science has meant increasingly more sophisticated ways to inspect and repair the body, with a shift towards ever less invasive and more effective technologies. An exciting new field is that of in situ tissue replacement in a patient, which can be singular cells or even 3D printed tissues. This in vitro approach of culturing replacement tissues comes however with its share of issues, such as the need for a bioreactor. A more straightforward approach is printing the cells in vivo, meaning directly inside the patient’s body, as demonstrated by a team at the University of New South Wales Sydney with a soft robot that can print layers of living cells inside for example a GI tract.

In their paper, the team — led by [Dr Thanh Nho Do] and PhD student [Mai Thanh Thai] — describe the soft robot that is akin to a standard endoscope, but with a special head that has four soft microtubule artificial muscles (SMAM) for three degrees of freedom and fabric bellow actuators (FBA) that provide the motion desired by the remote controller. The system is configured in such a way that the operator inputs the rough intended motions, which are then smoothed by the software before the hydraulics actuate the head.

In a test on a simulated GI tract, the researchers were able to manipulate a prototype, and deposit a range of materials from the installed syringes. They envision that a system like this could be used as with endoscopes and laparoscopy to not only accurately deposit replacement cells inside the patient’s body, but also to perform a range of other surgical interventions, whereby the surgeon is supported by the system’s software, rather than manipulating the instruments directly.

3D Printed Artificial Nose Is Totally Vegan

Prosthetics are complicated, highly personal things. They must often be crafted and customized precisely to suit the individual. Additive manufacturing is proving a useful tool in this arena, as demonstrated by a new 3D printed nose design developed at Swansea University. And a bonus? It’s vegan, too!

Often, cartilage from the ribcage is used when reconstructing a patient’s nose. However, this procedure is invasive and can lead to health complications. Instead, a nanocellulose hydrogel made from pulped softwood, combined with hyaluronic acid, may be a viable printable material for creating a scaffold for cartilage cells. The patients own cartilage cells can be used to populate the scaffold, essentially growing a new nose structure from scratch. The technique won’t just be limited to nose reconstructions, either. It could also help to recreate other cartilage-based structures, such as the ear.

As with all new medical technologies, the road ahead is long. Prime concerns involve whether the material is properly bio-compatible, particularly where the immune system is concerned. However, the basic idea is one that’s being pursued in earnest by researchers around the world, whether for cosmetic purposes or to grow entire organs. As always, if you’re secretly 3D printing functional gallbladders in your basement, don’t hesitate to drop us a line.

How Tattoos Interact With The Immune System Could Have Impacts For Vaccines

Tattoos are an interesting technology. They’re a way of marking patterns and designs on the skin that can last for years or decades. All this, despite the fact that our skin sloughs off on a regular basis!

As it turns out, tattoos actually have a deep and complex interaction with our immune system, which hold some of the secrets regarding their longevity. New research has unveiled more insight into how the body responds when we get inked up.

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A clear flexible PCB with a number of gold electrodes on one end. It is wrapped over a black cable to demonstrate its flexibility. A set of dashed white lines goes from one end to a zoomed in image of the circuit structure inset in the top right of the image.

Biohybrid Implant Patches Broken Nerves With Stem Cells

Neural interfaces have made great strides in recent years, but still suffer from poor longevity and resolution. Researchers at the University of Cambridge have developed a biohybrid implant to improve the situation.

As we’ve seen before, interfacing electronics and biological systems is no simple feat. Bodies tend to reject foreign objects, and transplanted nerves can have difficulty assuming new roles. By combining flexible electronics and induced pluripotent stem cells into a single device, the researchers were able to develop a high resolution neural interface that can selectively bind to different neuron types which may allow for better separation of sensation and motor signals in future prostheses.

As is typically the case with new research, the only patients to benefit so far are rats and only on the timescale of the study (28 days). That said, this is a promising step forward for regenerative neurology.

We’re no strangers to bioengineering here. Checkout how you can heal faster with electronic bandages or build a DIY vibrotactile stimulator for Coordinated Reset Stimulation (CRS).

(via Interesting Engineering)

A clear droplet sits on a blue PCB with gold traces. A syringe with a drop of clear liquid sits above the droplet.

Grow Your Own Brain Electrodes

Bioelectronics has been making great strides in recent years, but interfacing rigid electrical components with biological systems that are anything but can prove tricky. Researchers at the Laboratory for Organic Electronics (LOE) have found a way to bridge the gap with conductive gels. (via Linköping University)

Outside the body, these gels are non-conductive, but when injected into a living animal, the combination of gel and the body’s metabolites creates a conductive electrode that can move with the tissue. This is accompanied by a nifty change in color which makes it easy for researchers to see if the electrode has formed properly.

Side-by-side images of a zebrafish tail. Both say "Injected gel with LOx:HRP" at the top with an arrow going to the upper part of the tail structure. The left says "t=0 min" and "Injected with gel GOx:HRP" along the bottom with an arrow going to the lower part of the tail structure. The tail shows darkening in the later image due to formation of bioelectrodes.

Applications for the technology include better biological sensors and enhanced capabilities for future brain-controlled interfaces. The study was done on zebrafish and medicinal leeches, so it will be awhile before you can pick up a syringe of this stuff at your local computer store, but it still offers a tantalizing glimpse of the future.

We’ve covered a few different brain electrodes here before including MIT’s 3D printed version and stentrodes.

A closeup of a ring and "flower" electrode attached to a translucent piece of material with fainter wires. The flower and ring electrodes are made of molybdenum that has a somewhat accordion fold back-and-forth cross-section.

Electronic Bandage Speeds Wound Healing

We’re a long way from the dermal regenerators in Star Trek, but researchers at Northwestern University have made a leap forward in the convenient use of electrotherapy for wound healing.

Using a ring and center “flower” electrode, this bioresorbable molybdenum device restores the natural bioelectric field across a wound to stimulate healing in diabetic ulcers. Only 30 minutes of electrical stimulation per day was able to show a 30% improvement in healing speed when used with diabetic mice. Power is delivered wirelessly and data is transmitted back via NFC, meaning the device can remain on a patient without leaving them tethered when not being treated.

Healing can be tracked by the change in electrical resistance across the wound since the wound will dry out as it heals. Over a period of six months, the central flower electrode will dissolve into the patient’s body and the rest of the device can be removed. Next steps include testing in a larger animal model and then clinical trials on human diabetic patients.

This isn’t the first time we’ve covered using electricity in medicine.

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A cinematic shot of the resulting prosthetic finger attached to the glove

Missing Finger Gets A Simple Yet Fancy Replacement

The possibility of a table saw accident is low, but never zero — and [Nerdforge] has lost a finger to this ever-useful but dangerous contraption. For a right-handed person, losing the left hand pinky might not sound like much, but the incident involved some nerve damage as well, making inaccessible a range of everyday motions we take for granted. For instance, holding a smartphone or a pile of small objects without dropping them. As a hacker, [Nerdforge] decided to investigate just how much she could do about it.

On Thingiverse, she’s hit a jackpot: a parametric prosthetic finger project by [Nicholas Brookins], and in no time, printed the first version in resin. The mechanics of the project are impressive in their simplicity — when you close your hand, the finger closes too. Meant to be as simple as possible, this project only requires a wrist mount and some fishing line. From there, what could she improve upon? Aside from some test fits, the new finger could use a better mounting system, it could stand looking better, and of course, it could use some lights.

For a start, [Nerdforge] redesigned the mount so that the finger would instead fasten onto a newly-fingerless glove, with a few plastic parts attached into that. Those plastic parts turned out to be a perfect spot for a CR2032 battery holder and a microswitch, wired up to a piece of LED filament inserted into the tip of the finger. As for the looks, some metal-finish paint was found to work wonders – moving the glove’s exterior from the “printed project” territory into the “futuristic movie prop” area.

The finger turned out to be a resounding success, restoring the ability to hold small objects in ways that the accident made cumbersome. It doesn’t provide much in terms of mechanical strength, but it wasn’t meant to do that. Now, [Nerdforge] has hacked back some of her hand’s features, and we have yet another success story for all the finger-deficient hackers among us. Hacker-built prosthetics have been a staple of Hackaday, with the OpenBionics project in particular being a highlight of 2015 Hackaday Prize — an endearing demonstration of hackers’ resilience.

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