Growing Human Neurons Hooked Up To Electrodes

February 2, 2020 by Lewin Day 11 Comments

Philosophers have long mused about the concept of a “brain in a jar”, but thus far, it’s remained the preserve of science fiction rather than reality. However, after reading some scientific papers, [Justin] wanted to attempt the feat himself, so set out to grow some human neurons on an electrode array.

The project builds on [Justin]’s earlier work, using his DC sputtering rig to coat a glass microscope slide with electrodes. The first layer is silver for high conductivity, with an added gold layer for biocompatibility. The screw cap from a Falcon tube is then epoxied on to act as a reservoir for culture media for the neurons. Finally, an air filter is added to allow the biological mixture to breathe.

This was [Justin]’s first attempt at culturing neurons, and there were plenty of hurdles along the way. The custom culture assemblies had issues with the epoxy bonds leaking or failing entirely, leading to only one slide making it through the sterilization process. Additionally, the neurons were accidentally added in too high a quantity. While some growth was observed under the microscope, [Justin] was unable to detect any real signal from the system.

Despite a poor final result, plenty was learned along the way. [Justin] has already put plans into place to fix some of the pitfalls of the original experiment, and we look forward to seeing future updates from the project. Video after the break.

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See You On The Dark Side Of The Moon: China’s Lunar Radio Observatory

December 23, 2019 by Dan Maloney 6 Comments

For nearly as long as there has been radio, there have been antennas trained on the sky, looking at the universe in a different light than traditional astronomy. Radio astronomers have used their sensitive equipment to study the Sun, the planets, distant galaxies, and strange objects from the very edge of the universe, like pulsars and quasars. Even the earliest moments of the universe have been explored, a portrait in microwave radiation of the remnants of the Big Bang.

And yet with all these observations, there’s a substantial slice of the radio spectrum that remains largely a mystery to radio astronomers. Thanks to our planet’s ionosphere, most of the signals below 30 MHz aren’t observable by ground-based radio telescopes. But now, thanks to an opportunity afforded by China’s ambitious lunar exploration program, humanity is now listening to more of what the universe is saying, and it’s doing so from a new vantage point: the far side of the moon.

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Hiring From A Makerspace Pays Off

November 7, 2019 by Bryan Cockfield 12 Comments

A makerspace is a great place to use specialty tools that may be too expensive or large to own by oneself, but there are other perks that come with participation in that particular community. For example, all of the skills you’ve gained by using all that fancy equipment may make you employable in some very niche situations. [lukeiamyourfather] from the Dallas Makerspace recently found himself in just that situation, and was asked to image a two-million-year-old fossil.

The fossil was being placed into a CT machine for imaging, but was too thick to properly view. These things tend to be fragile, so he spent some time laser cutting an acrylic stand in order to image the fossil vertically instead of horizontally. Everything that wasn’t fossil had to be non-conductive for the CT machine, so lots of fishing line and foam was used as well. After the imaging was done, he was also asked to 3D print a model for a display in the museum.

This is all going on at the Perot Museum of Nature and Science if you happen to be in the Dallas area. It’s interesting to see these skills put to use out in the wild as well, especially for something as rare and fragile as studying an old fossil. Also, if you’d like to see if your local makerspace measures up to the Dallas makerspace, we featured a tour of it back in 2014, although they have probably made some updates since then.

Build Your Own Plasma Ball

October 25, 2019 by Sharon Lin 20 Comments

The simple plasma ball – it graces science museums and classrooms all around the world. It shares a place with the Van de Graaf generator, with the convenient addition of spectacular plasma rays that grace its spherical surface. High voltage, aesthetically pleasing, mad science tropes – what would make a better DIY project?

For some background, plasma is the fourth state of matter, often created by heating a neutral gas or ionizing the gas in a strong electromagnetic field. The availability of free electrons allows plasma to conduct electricity and exhibit different properties from ordinary gases. It is also influenced by magnetic fields in this state and can often be found in electric arcs.

[Discrete Electronics Guy] built a plasma bulb using the casing from an old filament bulb and an ignition coil connected to a high voltage power supply. The power supply is based on the 555 timer IC. It uses a step-up transformer (the ignition coil) driven by a square wave oscillator circuit at a high frequency working as AC voltage. The square wave signal boosts the current into the power transistor, increasing its power.

The plasma is produced inside the bulb, which contains inactive noble gases. When touching the surface of the bulb, the electric arc flows to the point of contact. The glass medium protects the skin from burning, but the transparency allows the plasma to be seen. Pretty cool!

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Willem Kolff’s Artificial Organs

October 9, 2019 by Dan Maloney 45 Comments

In my youth I worked for a paid ambulance service, and while we all lived for the emergency calls, the routine transports were the calls that paid the bills. Compared with the glamor and excitement of a lights-and-siren run to a car wreck or heart attack, transports were dull as dirt. And dullest of all were the daily runs from nursing homes to the dialysis center, where rows of comfy chairs sat, each before a refrigerator-sized machine designed to filter the blood of a patient in renal failure, giving them another few days of life.

Sadly, most of those patients were doomed; many were in need of a kidney transplant for which there was no suitable donor, while some were simply not candidates for transplantation. Dialysis was literally all that stood between them and a slow, painful death, and I could see that at least some of them were cheered by the sight of the waiting dialysis machine. The principles of how the kidneys work have been known since at least the 1800s, but it would take until 1945 for the efforts of a Dutch doctor, using used car parts and sausage casings, to make the predecessor of those machines: the first artificial kidney.

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Fantastic Micrometeorites And Where To Find Them

August 21, 2019 by Lewin Day 29 Comments

Space is very much the final frontier for humanity, at least as far as our current understanding of the universe takes us. Only a handful of countries and corporations on Earth have the hardware to readily get there, and even fewer are capable of reaching orbit. For these reasons, working in this field can seem out of reach for many. Nevertheless, there’s plenty about the great expanse beyond our atmosphere that can be studied by the dedicated citizen scientist. With the right equipment and know-how, it’s even possible to capture and study micrometeorites yourself!

While you don’t see a meteor shower every day, micrometeorites are actually astoundingly common. They’re just hard to find!

For those new to the field, the terms used can be confusing. Meteoroids are small metallic or rocky objects found in outer space, up to around 1 meter in size. When these burn up upon entering the atmosphere, they are referred to as a meteor, or colloquially known as a shooting star. If part of the object survives long enough to hit the ground, this is referred to as a meteorite, and as you’d expect the smaller ones are called micrometeorites, being on the scale of 2mm or less.

Stardust Proves Hard To Find

Being tiny and having fallen from space, micrometeorites present certain challenges to those who wish to find and identify them. In spite of this, they can be found by using the right techniques and a heck of a lot of hard work.

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Building A Bigger Cloud Chamber

July 20, 2019 by Lewin Day 11 Comments

Cloud chambers are an exciting and highly visual science experiment. They’re fascinating to watch as you can see the passage of subatomic particles from radioactive decay with your very own eyes. Many elect to build small chambers based on thermoelectric Peltier elements, but [Cloudylabs] decided to do something on a grander scale.

It’s a hefty chamber, and a very clean build.

[Cloudylabs] started building cloud chambers after first seeing one in a museum back in 2010. The first prototype was an air-cooled Peltier device, with a cooled area of just 4x4cm. Over the years, and after building many more Peltier-based chambers, it became apparent that the thermoelectric modules were somewhat less than robust, often failing after many thermal cycles. Wanting to take things up a notch, [Cloudylabs] elected to build a much larger unit based on phase-change technology, akin to the way a refrigerator works.

The final product is astounding, consisting of a 32x18cm actively cooled area mounted within a large glass viewing case. A magnet is mounted underneath which causes certain particles to curve in relation to the field, as well as an electrically charged grid up top. The chamber is capable of operating for up to 12 hours without requiring any user intervention.

Cloud chambers are always beautiful, and even moreso at this larger scale. When radioactive materials are introduced into the chamber the trails generated are long and easily visible. It’s a daunting build however, and the final product weighs over 30 kilograms. You might want to start with something a little smaller for your first build. Video after the break.

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