The PediSedate: A Winning Combination Of Video Games And Anesthesia

December 17, 2025 by Lewin Day 19 Comments

One can understand that it would be nice to have something to focus on while trying to remain calm ahead of a medical procedure. Credit: PediSedate

Once upon a time, surgery was done on patients who were fully conscious and awake. As you might imagine, this was a nasty experience for all involved, and particularly the patients. Eventually, medical science developed the techniques of anaesthesia, which allowed patients to undergo surgery without feeling pain or even being conscious of it at all.

Adults are typically comfortable in the medical environment and tolerate anaesthesia well. For children, though, the experience can be altogether more daunting. Thus was invented the PediSedate—a device which was marketed almost like a Game Boy accessory intended to deliver anaesthetic treatment in order to safely and effectively prepare children for surgery.

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Pufferfish Venom Can Kill, Or It Can Relieve Pain

December 15, 2025 by Lewin Day 21 Comments

Tetrodotoxin (TTX) is best known as the neurotoxin of the puffer fish, though it also appears in a range of other marine species. You might remember it from an episode of The Simpsons involving a poorly prepared dish at a sushi restaurant. Indeed, it’s a potent thing, as ingesting even tiny amounts can lead to death in short order.

Given its fatal reputation, it might be the last thing you’d expect to be used in a therapeutic context. And yet, tetrodotoxin is proving potentially valuable as a treatment option for dealing with cancer-related pain. It’s a dangerous thing to play with, but it could yet hold promise where other pain relievers simply can’t deliver. Continue reading “Pufferfish Venom Can Kill, Or It Can Relieve Pain” →

Little Lie Detector Is Probably No Worse Than The Big Ones

December 2, 2025 by Lewin Day 8 Comments

Want to know if somebody is lying? It’s always so hard to tell. [dbmaking] has whipped up a fun little polygraph, otherwise known as a lie detector. It’s nowhere near as complex as the ones you’ve seen on TV, but it might be just as good when it comes to finding the truth.

The project keeps things simple by focusing on two major biometric readouts — heart rate and skin conductivity. When it comes to the beating heart, [dbmaking] went hardcore and chose an AD8232 ECG device, rather than relying on the crutch that is pulse oximetry. It picks up heart signals via three leads that are just like those they stick on you in the emergency room. Skin conductivity is measured with a pair of electrodes that attach to the fingers with Velcro straps. The readings from these inputs are measured and then used to determine truth or a lie if their values cross a certain threshold. Presumably, if you’re sweating a lot and your heart is beating like crazy, you’re telling a lie. After all, we know Olympic sprinters never tell the truth immediately after a run.

Does this work as an actual, viable lie detector? No, not really. But that’s not just because this device isn’t sophisticated enough; commercial polygraph systems have been widely discredited anyway. There simply isn’t an easy way to correlate sweating to lying, as much as TV has told us the opposite. Consider it a fun toy or prop to play with, and a great way to learn about working with microcontrollers and biometric sensors.

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3D Printing And The Dream Of Affordable Prosthetics

December 1, 2025 by Maya Posch 13 Comments

As amazing as the human body is, it’s unfortunately not as amazing as e.g. axolotl bodies are, in the sense that they can regrow entire limbs and more. This has left us humans with the necessity to craft artificial replacement limbs to restore some semblance of the original functionality, at least until regenerative medicine reaches maturity.

Despite this limitation, humans have become very adept at crafting prosthetic limbs, starting with fairly basic prosthetics to fully articulated and beautifully sculpted ones, all the way to modern-day functional prosthetics. Yet as was the case a hundred years ago, today’s prosthetics are anything but cheap. This is mostly due to the customization required as no person’s injury is the same.

When the era of 3D printing arrived earlier this century, it was regularly claimed that this would make cheap, fully custom prosthetics a reality. Unfortunately this hasn’t happened, for a variety of reasons. This raises the question of whether 3D printing can at all play a significant role in making prosthetics more affordable, comfortable or functional.

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3D printed jaw with fake muscle attached

3D Printing For The Hospital Setting

November 28, 2025 by Ian Bos 9 Comments

Surgery is hard, there is a reason why school is so long for the profession. Making the job easier and smoother for both patients and surgeons is valuable for all parties, which is why [Mayo Clinic] is now working on including 3D printing into its more regular medicine pipeline.

Prepping for surgery often requires examining CT scans of patients to figure out, well, what they’re even going to be doing. Every body is different, and complex surgical procedures require checking to see where certain organs or features are located. This can be made much easier with a physical model of where the bones, organs, or nerves are specifically located in a patient. While this isn’t true in every case of treatment, there are even cancerous cases where custom equipment can be used to decrease side effects, such as mini-beam collimator adapters.

What if you could use the same pipeline to print what was lost from certain procedures? In a mastectomy, the breast tissue is removed, which can cause negative attention from curious gazes. So why not 3D print a custom breast? Cases like these are generally considered poor commercial investments from industry, but are relatively easy for an existing medical facility to add to treatment.

[Mayo Clinic] is far from the first to consider 3D printing in the medical setting, but seeing the technology see actual applied use rather than future seeking is exciting. Medical hacking is always exciting, and if you want to see more examples, keep sure to check out this commercially available simulator (with some free models).

DIY TENS Machine Is A Pain-Relief PCB

November 22, 2025 by Tyler August 36 Comments

Transcutaneous Electrical Nerve Stimulation (TENS) is one of those things that sounds like it must be woo when you first hear of it. “A trickle of current that can deal with chronic pain better than the pills we’ve been using for decades? Yeah, and what chakras do you hook this doo-hickie up to?” It seems too good to be true, but in fact it’s a well-supported therapy that has become part of scientific medicine. There are no crystals needed, and you’re applying electrodes to the effected area, not your chakras. Like all medical devices, it can be expensive if you have to buy the machine out-of-pocket… but it is just a trickle of current. [Leon Hillmann] shows us its well within the range of hackability, so why not DIY?

[Leon]’s TENS machine is specifically designed to help a relative with hand problems, so breaks out electrodes for each finger, with one on the palm serving as a common ground. This type of TENS is “monophasic”– that is, DC, which is easier than balancing current flowing in two directions through quivering flesh. The direct current is provided at 32 V to the digit electrodes, safely kept to a constant amperage with a transistor-based current limiting circuit. The common ground in the palm is pulsed at a rate set by an ATmega32U4 and thus controllable: 14 Hz is given as an example.

Obviously if you want to reproduce this work you’re doing it at your own risk and need to consult with relevant medical professionals (blah blah blah, caveat gluteus maximus) but this particular sort of medical device is a good fit for the average hacker. Aside from prosthetics, we haven’t seen that much serious medical hacking since the pandemic. Still, like with synthesizing medical drugs, this is the kind of thing you probably don’t want to vibe code.

Smart Bandage Leverages AI Model For Healing Purposes

November 19, 2025 by Lewin Day 14 Comments

If you get a small cut, you might throw a plastic bandage on it to help it heal faster. However, there are fancier options on the horizon, like this advanced AI-powered smart bandage.

Researchers at UC Santa Cruz have developed a proof-of-concept device called a-Heal, intended for use inside existing commercial bandages for colostomy use. The device is fitted with a small camera, which images the wound site every two hours. The images are then uploaded via a wireless connection, and processed with a machine learning model that has been trained to make suggestions on how to better stimulate the healing process based on the image input. The device can then follow these recommendations, either using electrical stimulation to reduce inflammation in the wound, or supplying fluoxetine to stimulate the growth of healthy tissue. In testing, the device was able to improve the rate of skin coverage over an existing wound compared to a control.

The long-term goal is to apply the technology in a broader sense to help better treat things like chronic or infected wounds that may have difficulty healing. It’s still at an early stage for now, but it could one day be routine for medical treatment to involve the use of small smart devices to gain a better rolling insight on the treatment of wounds. It’s not the first time we’ve explored innovative methods of wound care; we’ve previously looked at how treatments from the past could better inform how we treat in future.