The Use Of Ultrasound To Take On Cancerous Tumors

As areas of uncontrolled cell growth, cancerous growth form a major problem for a multi-celled organism like us humans. Thus before they can begin to affect our long-term prospects of a continued existence, eradicating these cells-gone-wrong is essential. Unfortunately, doing so without affecting healthy cells significantly is tough. Treatments such as chemotherapy are correspondingly rough on the body, while radiation therapy is a lot more directed. Perhaps one of the more fascinating treatments involves ultrasound, with the IEEE Spectrum magazine recently covering one company providing histotripsy equipment.

Diagram showing how HIFU can be used to destroy tissue in the body. An acoustic lens is used to focus sound to a small point in the body. (Credit: James Ross McLaughlan, Wikimedia)
Diagram showing how HIFU can be used to destroy tissue in the body. An acoustic lens is used to focus sound to a small point in the body. (Credit: James Ross McLaughlan, Wikimedia)

Ultrasound has found many applications in the medical field far beyond imaging, with therapeutic ultrasound by itself covering a variety of methods to perform actions within the body without breaking the skin. By using high-energy ultrasound, everything from kidney stones to fat cells and cancerous cells can be accurately targeted and destroyed. For liver tumors the application of so-called histotropsy has become quite common, allowing certain types of tumors to be ablated non-invasively after which the body can handle the clean-up.

Histotropsy is a form of high-intensify focused ultrasound (HIFU) that uses either continuous or pulsed waves to achieve the desired effect, with the HIFU transducer equipped with an acoustic lens to establish a focal point. In the case of histotripsy cavitation is induced at this focal point that ends up destroying the local tissue. Beyond liver tumors the expectation is that other tumors will soon be treated in a similar manner, which could be good news for especially solid tumors.

Along with new approaches like CAR T cell immunotherapy, the prospects for cancer becoming a very treatable set of diseases would seem to be brighter than ever.

Rectal Oxygenation Could Save Your Life One Day

Humans have lots of basic requirements that need to be met in order to stay alive. Food is a necessary one, though it’s possible to go without for great stretches of time. Water is more important, with survival becoming difficult beyond a few days in its absence. Most of all, though, we crave oxygen. Without an air supply, death arrives in mere minutes.

The importance of oxygen is why airway management is such a key part of emergency medicine. It can be particularly challenging in cases where there is significant trauma to the head, neck, or surrounding areas. In these cases, new research suggests there may be an alternative route to oxygenating the body—through the rear.

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Tackling Tremors With DIY Technology

[It’s Triggy!] had a problem to solve. His grandma was having issues with hand tremors, which made the basic tasks of daily life difficult to perform. He decided to explore whether a high-tech solution could help best the tremors and make life easier.

The video covers multiple ideas on how to stabilize a hand suffering involuntary tremors. The first build involved a gyroscope, which proved unsuccessful, but led to the idea of building a reaction wheel. The concept is simple — get the reaction wheel to counteract the forces from tremors to stabilize the hand. To achieve this, an accelerometer was employed to track the movements of the arm and the hand. The magnitude of the movement was then used to control a powerful brushless motor mounted on the wrist. If the tremor was driving a hard tilt to the left, the motor would spin up to create a counter-torque, cancelling out the involuntary movement. This worked to a degree, but the resulting device was large and noisy, which made it impractical.

This thus inspired a return to earlier work involving the use of a tuned mass damper to settle tremors. The combination of some 3D printed wrist mounts along with various spring and cantilever designs… ultimately didn’t work that well. By this point, [It’s Triggy!] had noticed the tremor was mostly in the hands, while the wrist stayed steady. Thus was inspired a wrist-mounted handle for the wearer to wrap their hand around. This allowed the use of simple handheld objects like kitchen utensils, with the wearer’s own grip suppressing the tremor successfully.

As this project demonstrates, sometimes high-tech solutions are the way to go, and other times… a more passive design will actually serve you better.

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The Quirky Peripherals In Medical PC Setups

Modern hospitals use a lot of computers. Architecturally speaking, they’re pretty typical machines—running the same CPUs and operating systems as any other PCs out there. However, they do tend to have some quirks when it comes to accessories and peripherals, as [tzukima] explores in a recent video.

The video starts by looking at typical power cables used with hospital computers and related equipment. In particular, [tzukima] talks about the common NEMA 5-15P to IEC-320-C13 style cable, which less sophisticated users might refer to as a kettle cord. In hospital-grade form, these cables are often constructed with translucent plug housings, with large cylindrical grips that make them easier to grip.

Digging further through business supply catalogs lead [tzukima] to discover further products aimed at hospital and medical users. In particular, there are a wide range of keyboards and mice that are designed for use in these environments. The most typical examples are regular peripherals that have simply been encased in silicone to make them easier to wash and disinfect where hygiene is paramount. Others, like the SealShield keyboard and mouse, use more advanced internally-sealed electronics to achieve their washable nature and IP68 ratings. These are peripherals that you can just throw in a dishwasher if you’re so inclined.

It’s a great look at weird hardware that most of us would never interact with.

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The PediSedate: A Winning Combination Of Video Games And Anesthesia

One can understand that it would be nice to have something to focus on while trying to remain calm ahead of a medical procedure. Credit: PediSedate

Once upon a time, surgery was done on patients who were fully conscious and awake. As you might imagine, this was a nasty experience for all involved, and particularly the patients. Eventually, medical science developed the techniques of anaesthesia, which allowed patients to undergo surgery without feeling pain or even being conscious of it at all.

Adults are typically comfortable in the medical environment and tolerate anaesthesia well. For children, though, the experience can be altogether more daunting. Thus was invented the PediSedate—a device which was marketed almost like a Game Boy accessory intended to deliver anaesthetic treatment in order to safely and effectively prepare children for surgery.

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Pufferfish Venom Can Kill, Or It Can Relieve Pain

Tetrodotoxin (TTX) is best known as the neurotoxin of the puffer fish, though it also appears in a range of other marine species. You might remember it from an episode of The Simpsons involving a poorly prepared dish at a sushi restaurant. Indeed, it’s a potent thing, as ingesting even tiny amounts can lead to death in short order.

Given its fatal reputation, it might be the last thing you’d expect to be used in a therapeutic context. And yet, tetrodotoxin is proving potentially valuable as a treatment option for dealing with cancer-related pain. It’s a dangerous thing to play with, but it could yet hold promise where other pain relievers simply can’t deliver. Continue reading “Pufferfish Venom Can Kill, Or It Can Relieve Pain”

Little Lie Detector Is Probably No Worse Than The Big Ones

Want to know if somebody is lying? It’s always so hard to tell. [dbmaking] has whipped up a fun little polygraph, otherwise known as a lie detector. It’s nowhere near as complex as the ones you’ve seen on TV, but it might be just as good when it comes to finding the truth.

The project keeps things simple by focusing on two major biometric readouts — heart rate and skin conductivity. When it comes to the beating heart, [dbmaking] went hardcore and chose an AD8232 ECG device, rather than relying on the crutch that is pulse oximetry. It picks up heart signals via three leads that are just like those they stick on you in the emergency room. Skin conductivity is measured with a pair of electrodes that attach to the fingers with Velcro straps. The readings from these inputs are measured and then used to determine truth or a lie if their values cross a certain threshold. Presumably, if you’re sweating a lot and your heart is beating like crazy, you’re telling a lie. After all, we know Olympic sprinters never tell the truth immediately after a run.

Does this work as an actual, viable lie detector? No, not really. But that’s not just because this device isn’t sophisticated enough; commercial polygraph systems have been widely discredited anyway. There simply isn’t an easy way to correlate sweating to lying, as much as TV has told us the opposite. Consider it a fun toy or prop to play with, and a great way to learn about working with microcontrollers and biometric sensors.

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