How Tattoos Interact With The Immune System Could Have Impacts For Vaccines

Tattoos are an interesting technology. They’re a way of marking patterns and designs on the skin that can last for years or decades. All this, despite the fact that our skin sloughs off on a regular basis!

As it turns out, tattoos actually have a deep and complex interaction with our immune system, which hold some of the secrets regarding their longevity. New research has unveiled more insight into how the body responds when we get inked up.

Continue reading “How Tattoos Interact With The Immune System Could Have Impacts For Vaccines”

A clear flexible PCB with a number of gold electrodes on one end. It is wrapped over a black cable to demonstrate its flexibility. A set of dashed white lines goes from one end to a zoomed in image of the circuit structure inset in the top right of the image.

Biohybrid Implant Patches Broken Nerves With Stem Cells

Neural interfaces have made great strides in recent years, but still suffer from poor longevity and resolution. Researchers at the University of Cambridge have developed a biohybrid implant to improve the situation.

As we’ve seen before, interfacing electronics and biological systems is no simple feat. Bodies tend to reject foreign objects, and transplanted nerves can have difficulty assuming new roles. By combining flexible electronics and induced pluripotent stem cells into a single device, the researchers were able to develop a high resolution neural interface that can selectively bind to different neuron types which may allow for better separation of sensation and motor signals in future prostheses.

As is typically the case with new research, the only patients to benefit so far are rats and only on the timescale of the study (28 days). That said, this is a promising step forward for regenerative neurology.

We’re no strangers to bioengineering here. Checkout how you can heal faster with electronic bandages or build a DIY vibrotactile stimulator for Coordinated Reset Stimulation (CRS).

(via Interesting Engineering)

A clear droplet sits on a blue PCB with gold traces. A syringe with a drop of clear liquid sits above the droplet.

Grow Your Own Brain Electrodes

Bioelectronics has been making great strides in recent years, but interfacing rigid electrical components with biological systems that are anything but can prove tricky. Researchers at the Laboratory for Organic Electronics (LOE) have found a way to bridge the gap with conductive gels. (via Linköping University)

Outside the body, these gels are non-conductive, but when injected into a living animal, the combination of gel and the body’s metabolites creates a conductive electrode that can move with the tissue. This is accompanied by a nifty change in color which makes it easy for researchers to see if the electrode has formed properly.

Side-by-side images of a zebrafish tail. Both say "Injected gel with LOx:HRP" at the top with an arrow going to the upper part of the tail structure. The left says "t=0 min" and "Injected with gel GOx:HRP" along the bottom with an arrow going to the lower part of the tail structure. The tail shows darkening in the later image due to formation of bioelectrodes.

Applications for the technology include better biological sensors and enhanced capabilities for future brain-controlled interfaces. The study was done on zebrafish and medicinal leeches, so it will be awhile before you can pick up a syringe of this stuff at your local computer store, but it still offers a tantalizing glimpse of the future.

We’ve covered a few different brain electrodes here before including MIT’s 3D printed version and stentrodes.

A closeup of a ring and "flower" electrode attached to a translucent piece of material with fainter wires. The flower and ring electrodes are made of molybdenum that has a somewhat accordion fold back-and-forth cross-section.

Electronic Bandage Speeds Wound Healing

We’re a long way from the dermal regenerators in Star Trek, but researchers at Northwestern University have made a leap forward in the convenient use of electrotherapy for wound healing.

Using a ring and center “flower” electrode, this bioresorbable molybdenum device restores the natural bioelectric field across a wound to stimulate healing in diabetic ulcers. Only 30 minutes of electrical stimulation per day was able to show a 30% improvement in healing speed when used with diabetic mice. Power is delivered wirelessly and data is transmitted back via NFC, meaning the device can remain on a patient without leaving them tethered when not being treated.

Healing can be tracked by the change in electrical resistance across the wound since the wound will dry out as it heals. Over a period of six months, the central flower electrode will dissolve into the patient’s body and the rest of the device can be removed. Next steps include testing in a larger animal model and then clinical trials on human diabetic patients.

This isn’t the first time we’ve covered using electricity in medicine.

Continue reading “Electronic Bandage Speeds Wound Healing”

A cinematic shot of the resulting prosthetic finger attached to the glove

Missing Finger Gets A Simple Yet Fancy Replacement

The possibility of a table saw accident is low, but never zero — and [Nerdforge] has lost a finger to this ever-useful but dangerous contraption. For a right-handed person, losing the left hand pinky might not sound like much, but the incident involved some nerve damage as well, making inaccessible a range of everyday motions we take for granted. For instance, holding a smartphone or a pile of small objects without dropping them. As a hacker, [Nerdforge] decided to investigate just how much she could do about it.

On Thingiverse, she’s hit a jackpot: a parametric prosthetic finger project by [Nicholas Brookins], and in no time, printed the first version in resin. The mechanics of the project are impressive in their simplicity — when you close your hand, the finger closes too. Meant to be as simple as possible, this project only requires a wrist mount and some fishing line. From there, what could she improve upon? Aside from some test fits, the new finger could use a better mounting system, it could stand looking better, and of course, it could use some lights.

For a start, [Nerdforge] redesigned the mount so that the finger would instead fasten onto a newly-fingerless glove, with a few plastic parts attached into that. Those plastic parts turned out to be a perfect spot for a CR2032 battery holder and a microswitch, wired up to a piece of LED filament inserted into the tip of the finger. As for the looks, some metal-finish paint was found to work wonders – moving the glove’s exterior from the “printed project” territory into the “futuristic movie prop” area.

The finger turned out to be a resounding success, restoring the ability to hold small objects in ways that the accident made cumbersome. It doesn’t provide much in terms of mechanical strength, but it wasn’t meant to do that. Now, [Nerdforge] has hacked back some of her hand’s features, and we have yet another success story for all the finger-deficient hackers among us. Hacker-built prosthetics have been a staple of Hackaday, with the OpenBionics project in particular being a highlight of 2015 Hackaday Prize — an endearing demonstration of hackers’ resilience.

Continue reading “Missing Finger Gets A Simple Yet Fancy Replacement”

A man with dark skin in a red shirt and khaki shorts sits in a chair. His left leg has a prosthetic below the knee. The upper half of the prosthethic is an off white plastic socket with flecks of different off white plastic throughout hinting at the recycled nature of the plastic. The lower half is a metal tube attached to an artificial foot in black sandals.

Precious Plastic Prosthetics

Plastic waste is a major problem, but what if you could turn the world’s trash into treasure? [Yayasan Kaki Kita Sukasada (YKKS)] in Indonesia is doing this by using recycled plastic to make prosthetic legs.

Polypropylene source material is shredded and formed into a sheet which is molded into the required shape for the socket. A layer of cloth and foam is used to cushion the interface between the patient and the socket itself. Using waste plastic to make parts for the prosthetics lowers the price for patients as well as helps to keep this material out of the landfill.

What makes this project really exciting is that [YKKS] employs disabled people who develop the prosthetics and also trains patients on how to maintain and repair their prosthetics with easily sourced tools and materials. With some medical device companies abandoning their devices, this is certainly a welcome difference.

We’ve previously covered the Precious Plastic machines used to make the plastic sheets and the organization’s developments at small scale injection molding.

Continue reading “Precious Plastic Prosthetics”

Top left of image shows a picture of a purplish-grey sea cucumber. Above the cucumber is the word "bio-inspiration." Arrows come from the cucumber to anthropomorphized cartoons of it saying "rigid" at the top with a cartoon sea cucumber standing straight up with spikes and the arrow captioned "soft" pointing down showing a crawling sea cucumber that looks more like a slug. To the right of the cucumber images is a set of three images stacked top to bottom. The top image is of a silver sphere with a zoomed-in atomic diagram with aligned magnetic poles next to it saying "solid state." The middle image shows arrows going up and down next to a snowflake and an artistic rendering of magnetic fields labeled "transition." The bottom image of this section shows a reddish sphere next to a zoomed-in atomic diagram where the magnetic poles are not aligned labeled "liquid state."

Phase Change Materials For Flexible And Strong Robots

Shape shifters have long been the stuff of speculative fiction, but researchers in China have developed a magnetoactive phase transitional matter (MPTM) that makes Odo slipping through an air vent that much more believable.

Soft robots can squeeze into small spaces or change shape as needed, but many of these systems aren’t as strong as their more mechanically rigid siblings. Inspired by the sea cucumber’s ability to manipulate its rigidity, this new MPTM can be inductively heated to a molten state to change shape as well as encapsulate or release materials. The neodymium-iron-boron (NdFeB) microparticles suspended in gallium will then return to solid form once cooled.

An image of a LEGO minifig behind bars. It moves toward the bars, melts, and is reconstituted on the other side after solidifying in a mold.

Applications in drug delivery, foreign object removal, and smart soldering (video after the break) probably have more real world impact than the LEGO minifig T1000 impersonation, despite how cool that looks. While a pick-and-place can do better soldering work on a factory line, there might be repair situations where a magnetically-controlled solder system could come in handy.

We’ve seen earlier work with liquid robots using gallium and bio-electronic hybrids also portending the squishy future of robotics.

Continue reading “Phase Change Materials For Flexible And Strong Robots”