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958 Articles

Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

September 21, 2021 by 85 Comments

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Farewell Sir Clive Sinclair; Inspired A Generation Of Engineers

September 16, 2021 by 74 Comments

It is with sadness that we note the passing of the British writer, engineer, home computer pioneer, and entrepreneur, Sir Clive Sinclair, who died this morning at the age of 81 after a long illness. He is perhaps best known among Hackaday readers for his ZX series of home computers from the 1980s, but over a lifetime in the technology industry there are few corners of consumer electronics that he did not touch in some way.

Sinclair’s first career in the 1950s was as a technical journalist and writer, before founding the electronics company Sinclair Radionics in the 1960s. His output in those early years was a mixture of miniature transistor radios and Hi-Fi components, setting the tone for decades of further tiny devices including an early LED digital watch at the beginning of the 1970s, miniature CRT TVs in the ’70s and ’80s, and another tiny in-ear FM radio which went on sale in the ’90s.

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a variety of enclosure options

The Many Ways To Solve Your Enclosure Problems

September 15, 2021 by 63 Comments

Most projects around here involve some sort of electronics, and some sort of box to put them in. The same is true of pretty much all commercially available electronic products as well.

Despite that, selecting an enclosure is far from a solved problem. For simple electronics it’s entirely possible to spend more time getting the case just right than working on the circuit itself. But most of the time we need to avoid getting bogged down in what exactly will house our hardware.

The array of options available for your housing is vast, and while many people default to a 3D printer, there are frequently better choices. I’ve been around the block on this issue countless times and wanted to share the options as I see them, and help you decide which is right for you. Let’s talk about enclosures!

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Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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The World’s First Autonomous Electric Cargo Ship Is Due To Set Sail

September 14, 2021 by 55 Comments

Maritime shipping is big business, with gigantic container ships responsible for moving the vast majority of the world’s goods from point A to points B, C and D. Of course, there’s a significant environmental impact from all this activity, something ill befitting the cleaner, cooler world we hope the future will be. Thus, alternatives to the fossil fuel burning ships of old must be found. To that end, Norwegian company Yara International has developed a zero-emission ship by the name of Yara Birkeland, which aims to show the way forward into a world of electric, autonomous sea transport. 

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Pulling the Google logo off of a smartphone

Pining For A De-Googled Smartphone

September 2, 2021 by 89 Comments

Last summer in the first swings of the global pandemic, sitting at home finally able to tackle some of my electronics projects now that I wasn’t wasting three hours a day commuting to a cubicle farm, I found myself ordering a new smartphone. Not the latest Samsung or Apple offering with their boring, predictable UIs, though. This was the Linux-only PinePhone, which lacks the standard Android interface plastered over an otherwise deeply hidden Linux kernel.

As a bit of a digital privacy nut, the lack of Google software on this phone seemed intriguing as well, and although there were plenty of warnings that this was a phone still in its development stages it seemed like I might be able to overcome any obstacles and actually use the device for daily use. What followed, though, was a challenging year of poking, prodding, and tinkering before it got to the point where it can finally replace an average Android smartphone and its Google-based spyware with something that suits my privacy-centered requirements, even if I do admittedly have to sacrifice some functionality.

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The Postmortem Password Problem

September 1, 2021 by 82 Comments

Death and passwords: two things we just can’t avoid. With so much of our lives tied up in cloud services nowadays, there’s good reason to worry about what happens to these accounts if we drop dead tomorrow. For many of us, important documents, photos, financial information and other data will be locked behind a login prompt. Your payment methods will also expire shortly after you have, which could lead to data loss if not handled promptly. The most obvious way to address this is to give a trusted party access in case of emergency.

A Bad Solution

Let’s start with the simplest solution: using the same password everywhere.  Great, all you need to do is put this on a Post-it note, stuff it in an envelope, and let someone know where to find it. Unfortunately, using a single password for many services is a terrible idea. Password breaches happen, and if you’re using a single password across the internet, they can be disastrous.

Password breaches are usually the result of an attacker finding a vulnerability that allows reading password data from an application’s database. Odds are high that your information has been leaked in one of these breaches. You can check if your email is on a list of known breaches with Have I Been Pwned. Don’t feel bad if you’ve been pwned, my email shows up on six different breaches, and this service only indexes publicly known breaches!

Depending on the competency of the company that was breached, your password may have been stolen in a few different formats. In the worst case, the passwords were stored as-is (i.e., cleartext), and the breach contains your actual password. Nowadays, storing passwords in cleartext is never considered acceptable. A hash of the password is stored instead. Attackers need to use a tool like hashcat to try to recover the passwords via brute force hash cracking. This is slow for complex passwords, but is always getting faster as GPUs improve.

So we really need to use different passwords everywhere, or our Tumblr account from 2013 could give access to our bank account. Given the large number of services we use and our inability to remember passwords, we’re going to need to use a password manager. Continue reading “The Postmortem Password Problem” →