3D reconstruction of x-rayed worms. X-ray absorbing particles in the guts are shown in white.

Earthworms Don’t Bio-Accumulate Microplastics, So There May Be Hope For Us

Microplastics absolutely saturate the Earth’s environment, and that’s probably not a good thing unless you’re looking for a sediment marker for the Anthropocene period. On the other hand, environmental contamination only becomes a really big problem if it bioaccumulates– that is, builds up in the tissues of plants and animals. At least when it comes to worms, that’s not the case with microplastics, according to new research from the Canadian Light Source at the University of Saskatchewan.

Pictured: Not an Igloo.
Credit: David Stobbe / Stobbe Photography, via University of Saskatchewan

The Canadian Light Source isn’t just some hoseheads in an igloo with a flashlight– it’s a 2.9 GeV Synchrotron tuned to produce high-energy photons. Back when Synchrotrons were used for particle physics, Synchrotron radiation was a very annoying energy sink, but nobody cares about 2.9 GeV electrons anymore. So rather than slam them into each other or a static target, the electrons just whip about endlessly, giving off both soft- and hard X-rays for material science studies– or, in this case, to observe the passage of polyethelyne microplastic particles through the guts of some very confused earth worms. To make them detectable by x-ray, the polyethylene was bonded to barium sulfate, an x-ray absorber. Equally opaque barium titanite glass microspheres were used with different worms, as a control.

Despite being fed soil enriched with far more plastic than you’ll find outside of a 3D print farm, it seems the worm’s digestive system was able to reject the particles, even those as fine as 5 microns. That’s a good thing, because if the worms were absorbing plastic from the soil, it’s likely their predators would absorb it from the flesh of the worms, so and so forth up the food chain in the sort of cascade that made DDT a problem and makes mercury compounds so serious. If the worms are rejecting these compounds, there’s a chance other creatures can too– and at the very least, it means they aren’t building up on this bottom rung of the foot chain. If you’re looking for a more technical read, the full paper is available here.

It’s too early to say what this means for how microplastics get into humans and other animals, but it’s hopeful. Equally hopeful was the recent finding that studies that don’t rely on football-field sized X-ray machines might be picking up on microplastics from lab gloves, skewing results.

Header image: the digestive systems of earth worms as imaged by the Canadian Light Source. Credit Letwin, et al,
Environmental Toxicology and Chemistry, vgag072, https://doi.org/10.1093/etojnl/vgag072

Strange Ways To Make Cold

Making stuff cool and keeping it that way has been a pretty essential part of human civilization for thousands of years, with only in the past few hundred years man-made methods having become available that remove the reliance on the whims of nature and lugging around massive blocks of ice. The most important cooling method is undoubtedly that of vapor-compression refrigeration, but this is hardly the only method to transfer thermal energy from one location to another.

For example, we recently covered an elastocaloric cooling project by a group of scientists that uses strips of NiTi metal. By flexing these they induce a cooling effect which when put in a number of stages serves to transfer a significant amount of thermal energy between both sides, much like a vapor-compression system but without the gases and compressor. Meanwhile the Seebeck effect is relatively well-known from Peltier thermocouple devices, and features heavily in portable refrigerators and kin where these solid-state devices can also transfer thermal energy.

Of course, along with how they function the major question with all of these cooling technologies is how efficient they are, as this determines when you’d want to even consider them for a specific application.

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Electronics Near Zero

Normally, when you design an electronic gadget, you worry about how hot it will get. Automotive-grade components, for example, often have higher allowable temperatures than commercial parts. However, extremely cold environments, such as deep space or the interiors of quantum computers, are also challenging. Researchers at King Abdullah University of Science and Technology believe gallium oxide may be key to operating near absolute zero.

According to [Vishal Khandelwal], one of the researchers, most conventional electronics fail below -173C or 100K. Quantum computers routinely operate at 4K. However, β-Ga2O3 is a wide-bandgap semiconductor that has low current leakage and works at high temperatures up to 500C. However, it also avoids the freeze-out effect that traps electrons in other semiconductor materials.

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Why Solid State Batteries Short

Solid state batteries, we are told, are the new hot battery technology that will replace lithium-ion batteries. Soon. Not that we haven’t heard that before. One reason it isn’t dominating the market today is that it’s prone to short circuits during charging. [Dr. Yuwei Zhang and others have published a paper detailing why the shorts happen, which could lead to strategies to improve the technology.

Solid state batteries employ a solid electrolyte and a lithium anode. It is known that, sometimes, lithium metal from the anode forms dendrites that penetrate the ceramic electrolyte and cause it to crack. This is somewhat of a mystery as the lithium is a soft metal: to quote [Zhang], “like a gummy bear”.

There were two leading hypotheses for the observations. [Zhang’s] team showed that hydrostatic stress made the lithium dendrites act like a water jet, enabling them to penetrate the hard ceramic.

There is still work to figure out what to do about it, but understanding the root cause is certainly a step in the right direction. We’ve looked at these batteries before. We’ve also seen how changing the anode construction might help with the problem.

Quantum Computers Are Not A Threat To 128-bit Symmetric Keys

A lot has been made about a post-quantum computer future in which traditional encryption methods have suddenly been rendered obsolete. With this terrifying idea in mind, it’s reassuring to see some recent pushback to the idea with some factual evidence. In a recent blog post by [Filippo Valsorda] – a cryptography engineer – the point is raised that 128-bit symmetric keys like AES-128 and hashing algorithms like SHA-256 are not at risk of being obliterated in a post-quantum future.

Rather than just taking [Filippo]’s word for it, he takes us through a detailed explanation of the flawed understanding of Grover’s algorithm that underlies much of the panic. While it’s very true that this quantum search algorithm can decrease the amount of time required to find a solution, the speed-up with a single thread is quadratic, not exponential. While asymmetric cryptography systems like ECDH, RSA, and kin are very much at risk courtesy of Shor’s algorithm, the same is not true for symmetric systems.

An interesting detail with Grover’s is also that you cannot simply run a search in parallel to get a corresponding speed-up, as it’s not a parallel problem. Barring a breakthrough that replaces Grover’s with something that lends itself better to such a parallel search, it would seem that we won’t have to abandon classical encryption any time soon.

Incidentally, even for Shor’s algorithm, there are still some hold-ups. Current quantum computers are not even able to factor 21 yet. Meanwhile, supposed quantum computing breakthroughs are being trolled with a Commodore 64.

Muon Magnetic Moment Matches Model, Making Major Malaise

Sometimes, a major discovery is exactly what you were hoping not to find. That’s the case with a team at Penn State who seem to have recently closed the door on any new physics stemming from a longstanding discrepency in the magnetic moment of the muon. It turns out, the model was fine, and we just needed better calculations.

The Muon is a heavier cousin to the electron. Like the electron, it has an intrinsic magnetic moment, but the traditional methods to calculate it did not quite match experiments, which was very exciting because it made us hope our models could be improved. Rather than try the traditional approximation methods for the unsolvable equations, the group at Penn State set up what you can think of as the Quantum Chromodynamic equivalent of a Finite Element Model (FEM) simulation–a grid of discrete steps in space and time. Tiny ones, of course, because the muon, like the electron, is a point-like particle with no lower size limit. In any case, according to their paper in Nature, after a decade of refinement and increasingly expensive supercomputer runs, the mystery can be put to bed. Instead of the discrepancy that so exited physicists 25 years ago when it was first found, theory and experiment now match to 11 digits, or a 0.5 sigma discrepancy, if you prefer.

Statistically, the Standard Model works– and that kind of sucks. It sucks, because it’s the gaps in the model where new physics are possible, and everyone has been pushing at those few gaps for the last 50 years to try and find what might be behind the standard model. Even [Zoltan Fodor], the principle investigator behind this project, is sad to see it work out. Sure, it’s a feather in his cap to get the calculations right at last–but ask anybody in the field, and they’d rather keep the door open to new physics than be right. We were certainly hoping it was something novel, last time the topic came up.

You might think muons are the last thing a hacker would ever encounter, but since there’s a steady rain of them from the sky in the form of cosmic rays, it’s not only easy to interact with them, you can actually put them to practical use– like muon tomography, or navigation indoors and underground.

Header Image Credit: Dani Zemba / Penn State

How Gut Bacteria May Affect The Outcome Of Cancer Immunotherapy

In the ongoing development of cancer immunotherapy, as well as our still developing understanding of the human immune system, there’s always been a bit of massive elephant in the room. The thing about human bodies is that they’re not just human cells, but also consist of trillions of bacteria that mostly live in the intestines. What effect these bacteria have on the immune system’s functioning and from there on immunotherapies was recently investigated by [Tariq A. Najar] et al., with an article published in Nature.

The relevant topic here is that of antigenic mimicry, involving microbial antigens that resemble self-antigens. Since these self-antigens are a crucial aspect of both autoimmune diseases and cancer immunotherapy there is considerable room for interaction with their microbial mimics. Correspondingly these mimics can have considerable negative as well as positive implications, ranging from potentially triggering an autoimmune condition to hindering or boosting cancer immunotherapy.

In this study mice were used to investigate the effect of such microbial interference, in particular focusing on immune checkpoint blockade (ICB), which refers to negative feedback responses within the immune system that some cancers use to protect themselves. In some immunotherapy patients ICB inhibiting using e.g. anti programmed cell death protein (anti-PD-1) treatment does not provoke a response for some reason.

For the study mice had tumors implanted and the effect of a particular microbe (segmented filamentous bacteria, SFB) on it studied, with the presence of it markedly improving the response to anti-PD-1 treatment due to anti-gens expressed by SFB despite the large gut-skin distance. Whether in humans similar mechanisms play a similarly strong role remains to be investigated, but it offers renewed hope that cancer immunotherapies like CAR T-cell immunotherapy will one day make cancer an easily curable condition.