An Insulin Injection That Lasts For Days: A New Hope For Diabetics

December 27, 2023 by Maya Posch 12 Comments

A major challenge for people who have a form of diabetes is the need to regulate the glucose levels in their body. Normally this is where the body’s insulin-producing cells would respond to glucose with a matching amount of insulin, but in absence of this response it is up to the patient to manually inject insulin. Yet recent research offers the hope that these daily injections might be replaced with weekly injections, using insulin-binding substances that provide a glucose-response rather like the natural one. One such approach was tested by Juan Zhang and colleagues, with the results detailed in Nature Biomedical Engineering.

In this study, the researchers injected a group of diabetic (type 1) mice and minipigs with the formulation, consisting out of gluconic acid-modified recombinant human insulin bound to a glucose-responsive phenylboronic acid-diol complex. The phenylboronic acid element binds more easily to glucose, which results in the insulin being released, with no significant hypoglycemia observed in this small non-human test group. A major advantage of this mechanism is that it is fully self-regulating through the amount of glucose present in the blood.

This study is similar to work by Sijie Xian and colleagues published in Advanced Materials (ChemRxiv preprint) where a similar complex of glucose-sensitive, bound insulin complex was studied, albeit in vitro. With non-human animal testing showing good results for this method, human trials may not be far off, which could mean the end to daily glucose and insulin management for millions in the US alone.

(Top image: Chemical structures of the insulin-DiPBA complex and its functioning. Credit: Sijie Xian et al., 2023)

Temperature Measurement By Wire

December 27, 2023 by Al Williams 7 Comments

There’s an old joke about how to tell how tall a building is using a barometer. The funniest answer is to find the building owner and offer them a nice barometer in exchange for the information. We wonder if [DiodeGoneWild] has heard that one since his recent video details how to measure temperatures using an ohmmeter.

The idea is that wire changes its resistance based on temperature. So if you know the resistance of a lot of wire — maybe a coil — at room temperature and you can measure the resistance at temperature, it is entirely feasible to calculate the amount of temperature that would cause this rise in resistance.

Of course, there are many ways to measure resistance, too. It’s probably possible to measure parameters like operating current and estimate temperature for at least some circuits. The wire’s material also plays a part, and the online calculator lets you choose copper, aluminum, iron, or tungsten. You also need a lot of wire, a very accurate resistance measurement, or, preferably, both.

There are many ways to accurately measure resistance, of course. Then again, you can also get resistors specifically for the job.

Continue reading “Temperature Measurement By Wire” →

China’s Nuclear-Powered Containership: A Fluke Or The Future Of Shipping?

December 26, 2023 by Maya Posch 73 Comments

Since China State Shipbuilding Corporation (CSSC) unveiled its KUN-24AP containership at the Marintec China Expo in Shanghai in early December of 2023, the internet has been abuzz about it. Not just because it’s the world’s largest container ship at a massive 24,000 TEU, but primarily because of the power source that will power this behemoth: a molten salt reactor of Chinese design that is said to use a thorium fuel cycle. Not only would this provide the immense amount of electrical power needed to propel the ship, it would eliminate harmful emissions and allow the ship to travel much faster than other containerships.

Meanwhile the Norwegian classification society, DNV, has already issued an approval-in-principle to CSSC Jiangnan Shipbuilding shipyard, which would be a clear sign that we may see the first of this kind of ship being launched. Although the shipping industry is currently struggling with falling demand and too many conventionally-powered ships that it had built when demand surged in 2020, this kind of new container ship might be just the game changer it needs to meet today’s economic reality.

That said, although a lot about the KUN-24AP is not public information, we can glean some information about the molten salt reactor design that will be used, along with how this fits into the whole picture of nuclear marine propulsion.

Continue reading “China’s Nuclear-Powered Containership: A Fluke Or The Future Of Shipping?” →

Absorbing Traffic Noise With Bricks Using Helmholtz Resonators

December 24, 2023 by Maya Posch 25 Comments

One inevitable aspect of cities and urban life in general is that it is noisy, with traffic being one of the main sources of noise pollution. Finding a way to attenuate especially the low-frequency noise of road traffic was the subject of [Joe Krcma]’s Masters Thesis, the results of which he gave a talk on at the Portland Maker Meetup Club after graduating from University College London. The chosen solution in his thesis are Helmholtz resonators, which are a kind of acoustic spring. Using a carefully selected opening into the cavity, frequencies can be filtered out, and extinguished inside the cavity.

Basic functionality and formula used to determine the dimensions of a Helmholtz Resonator.

As examples of existing uses of Helmholtz resonators in London, he points at the Queen Elizabeth Hall music venue, as well as the newly opened Queen Elizabeth Line and Paddington Station. For indoor applications there are a number of commercial offerings, but could this be applied to outdoor ceramics as well, to render urban environments into something approaching an oasis of peace and quiet?

For the research, [Joe]’s group developed a number of Helmholtz resonator designs and manufacturing methods, with [Joe] focusing on clay fired versions. For manufacturing, 3D printing of the clay was attempted, which didn’t work out too well. This was followed by slip casting, which allowed for the casting of regular rectangular bricks.

But after issues with making casting hollow bricks work, as well as the cracking of the bricks during firing in the kiln, the work of another student in the group inspired [Joe] to try a different approach. The result was a very uniquely shaped ‘brick’ that, when assembled into a wall, forms three Helmholtz resonators: inside it, as well as two within the space with other bricks. During trials, the bricks showed similar sound-deadening performance as foam and wood. He also made the shape available on Thingiverse, if you want to try printing or casting it yourself.

Continue reading “Absorbing Traffic Noise With Bricks Using Helmholtz Resonators” →

UK’s JET Tokamak Retires After 40 Years And 105,842 Pulses

December 23, 2023 by Maya Posch 20 Comments

The UK’s most famous fusion reactor – the Joint European Torus (JET) tokamak – saw its first plasma on June 25th of 1983. Its final plasma pulse was generated on December 18th of 2023, for a total of 105,842 pulses over forty-and-a-half years and countless experiments.

Comparison of toroidal field (TF) coils from JET, JT-60SA and ITER (Credit: QST)

Originally designed in the 1970s by Euratom members, JET formed the core of Europe’s fusion research program, allowing many of the aspects of tokamak systems to be explored, including deuterium-tritium fusion. Its final day of experiments involved an inverted plasma shape prior to targeting electrons at the tokamak’s inner wall, to study the impact of such damage.

Although JET has received a number of upgrades over the decades, the MAST Upgrade and upcoming STEP fusion reactors at the Culham Centre for Fusion Energy (CCFE) are now headed where JET’s design cannot go. Current advanced tokamak reactors like Japan’s JT-60SA are increasingly using super-conducting coils with often plasma volumes far beyond JET’s, with the focus shifting from plasma research to net energy production.

This means that unless JET somehow gets repurposed/upgraded and recommissioned, this is the final goodbye to one of the world’s most famous and influential fusion reactors.

(Top image: Internal view of the JET tokamak superimposed with an image of plasma flows)

A Transistor, But For Heat Instead Of Electrons

December 20, 2023 by Donald Papp 31 Comments

Researchers at UCLA recently developed what they are calling a thermal transistor: a solid-state device able to control the flow of heat with an electric field. This opens the door to controlling the transfer of heat in some of the same ways we are used to controlling electronics.

Heat management can be a crucial task, especially where electronics are involved. The usual way to manage heat is to draw it out with things like heat sinks. If heat isn’t radiating away fast enough, a fan can be turned on (or sped up) to meet targets. Compared to the precision and control with which modern semiconductors shuttle electrons about, the ability to actively manage heat seems lacking.

This new device can rapidly adjust thermal conductivity of a channel based on an electrical field input, which is very similar to what a transistor does for electrical conductivity. Applying an electrical field modifies the strength of molecular bonds in a cage-like array of molecules, which in turn adjusts their thermal conductivity.

It’s still early, but this research may open the door to better control of heat within semiconductor systems. This is especially interesting considering that 3D chips have been picking up speed for years (stacking components is already a thing, it’s called Package-on-Package assembly) and the denser and deeper semiconductors get, the harder it is to passively pull heat out.

Thanks to [Jacob] for the tip!

The Hot Chocolate Effect Explained

December 17, 2023 by Al Williams 19 Comments

This is the time of year when people in the Northern Hemisphere like to enjoy hot beverages like hot chocolate. [The Action Lab] uses hot chocolate to demonstrate an odd acoustic effect. Tapping a container of hot chocolate — or even just hot water — will make a sound at a certain frequency. But if you keep tapping, the frequency of the sound will gradually increase. Don’t know why? Don’t worry, neither did scientists until around 1980.

The secret is bubbles and the speed of sound through air vs a liquid. The speed of sound in the liquid and the height of the liquid in the cup set the frequency. However, the speed of sound changes based on the bubbles, which alters the frequency.

Continue reading “The Hot Chocolate Effect Explained” →