An image of the surface of Europa. The top half of the sphere is illuminated with the bottom half dark. The surface is traced with lineae, long lines across its surface of various hues of grey, white, and brown. The surface is a brown-grey, somewhat like Earth's Moon with the highest brightness areas appearing white.

Europa Clipper Asks Big Questions Of The Jovian Moon

April 5, 2024 by Navarre Bartz 16 Comments

Are we alone? While we certainly have lots of strange lifeforms to choose from as companions here on our blue marble, we have yet to know if there’s anything else alive out there in the vastness of space. One of the most promising places to look in our own solar neighborhood is Europa.

Underneath its icy surface, Europa appears to have a sea that contains twice as much water as we have here on Earth. Launching later this year and arriving in 2030, NASA’s Europa Clipper will provide us with our most up-close-and-personal look at the Jovian Moon yet. In conjunction with observations from the ESA’s Jupiter Icy Moons Explorer (JUICE), scientists hope to gain enough new data to see if the conditions are right for life.

Given the massive amounts of radiation in the Jovian system, Europa Clipper will do 50 flybys of the moon over the course of four years to reduce damage to instruments as well as give it windows to transmit data back to Earth with less interference. With enough planning and luck, the mission could find promising sites for a future lander that might be able to better answer the question of if there actually is life on other worlds.

Some of the other moons around Jupiter could host life, like Io. Looking for life a little closer? How about on our nearest neighbor, Venus, or the ever popular Mars?

Complex Organic Chemistry In Sulfuric Acid And Life On Venus

March 25, 2024 by Maya Posch 25 Comments

Finding extraterrestrial life in any form would be truly one of the largest discoveries in humankind’s history, yet after decades of scouring the surface of Mars and investigating other bodies like asteroids, we still have found no evidence. While we generally assume that we’re looking for carbon-based lifeforms in a water-rich environment like Jupiter’s moon Europa, what if complex organic chemistry would be just as happy with sulfuric acid (H₂SO₄) as solvent rather than dihydrogen monoxide (H₂O)? This is the premise behind a range of recent studies, with a newly published research article in Astrobiology by [Maxwell D. Seager] and colleagues lending credence to this idea.

Previous studies have shown that organic chemistry in concentrated sulfuric acid is possible, and that nucleic acid bases – including adenosine, cytosine, guanine, thymine and uracil which form DNA – are also stable in this environment, which is similar to that of the Venusian clouds at an altitude where air pressure is roughly one atmosphere. In this new article, twenty amino acids were exposed to the concentrations of sulfuric acid usually found on Venus, at 98% and 81%, with the rest being water. Of these, 11 were unchanged after 4 weeks, 9 were reactive on their side chains, much like they would have been in pure water. Only tryptophan ended up being unstable, but as the researchers note, not all amino acids are stable in water either.

Continue reading “Complex Organic Chemistry In Sulfuric Acid And Life On Venus” →

An Insulin Injection That Lasts For Days: A New Hope For Diabetics

December 27, 2023 by Maya Posch 12 Comments

A major challenge for people who have a form of diabetes is the need to regulate the glucose levels in their body. Normally this is where the body’s insulin-producing cells would respond to glucose with a matching amount of insulin, but in absence of this response it is up to the patient to manually inject insulin. Yet recent research offers the hope that these daily injections might be replaced with weekly injections, using insulin-binding substances that provide a glucose-response rather like the natural one. One such approach was tested by Juan Zhang and colleagues, with the results detailed in Nature Biomedical Engineering.

In this study, the researchers injected a group of diabetic (type 1) mice and minipigs with the formulation, consisting out of gluconic acid-modified recombinant human insulin bound to a glucose-responsive phenylboronic acid-diol complex. The phenylboronic acid element binds more easily to glucose, which results in the insulin being released, with no significant hypoglycemia observed in this small non-human test group. A major advantage of this mechanism is that it is fully self-regulating through the amount of glucose present in the blood.

This study is similar to work by Sijie Xian and colleagues published in Advanced Materials (ChemRxiv preprint) where a similar complex of glucose-sensitive, bound insulin complex was studied, albeit in vitro. With non-human animal testing showing good results for this method, human trials may not be far off, which could mean the end to daily glucose and insulin management for millions in the US alone.

(Top image: Chemical structures of the insulin-DiPBA complex and its functioning. Credit: Sijie Xian et al., 2023)

Ecological System Dynamics For Computing

June 23, 2023 by Navarre Bartz 3 Comments

Some of you may remember that the ship’s computer on Star Trek: Voyager contained bioneural gel packs. Researchers have taken us one step closer to a biocomputing future with a study on the potential of ecological systems for computing.

Neural networks are a big deal in the world of machine learning, and it turns out that ecological dynamics exhibit many of the same properties. Reservoir Computing (RC) is a special type of Recurrent Neural Network (RNN) that feeds inputs into a fixed-dynamics reservoir black box with training only occurring on the outputs, drastically reducing the computational requirements of the system. With some research now embodying these reservoirs into physical objects like robot arms, the researchers wanted to see if biological systems could be used as computing resources.

Using both simulated and real bacterial populations (Tetrahymena thermophila) to respond to temperature stimuli, the researchers showed that ecological system dynamics has the “necessary conditions for computing (e.g. synchronized dynamics in response to the same input sequences) and can make near-future predictions of empirical time series.” Performance is currently lower than other forms of RC, but the researchers believe this will open up an exciting new area of research.

If you’re interested in some other experiments in biocomputing, checkout these RNA-based logic gates, this DNA-based calculator, or this fourteen-legged state machine.

Microfluidics For Biohacking Hack Chat

July 5, 2021 by Dan Maloney 2 Comments

Join us on Wednesday, July 7 at noon Pacific for the Microfluidics for Biohacking Hack Chat with Krishna Sanka!

“Microfluidics” sounds like a weird and wonderful field, but one that doesn’t touch regular life too much. But consider that each time you fire up an ink-jet printer, you’re putting microfluidics to work, as nanoliter-sized droplets of ink are spewed across space to impact your paper at exactly the right spot.

Ink-jets may be mundane, but the principles behind them are anything but. Microfluidic mechanisms have found their way into all sorts of products and processes, with perhaps the most interesting uses being leveraged to explore and exploit the microscopic realms of life. Microfluidics can be used to recreate some of the nanoscale biochemical reactions that go on in cells, and offer not only new ways to observe the biological world, but often to manipulate it. Microfluidics devices range from “DNA chips” that can rapidly screen drug candidates against thousands of targets, to devices that can rapidly screen clinical samples for exposure to toxins or pathogens.

There are a host of applications of microfluidics in biohacking, and Krishna Sanka is actively working to integrate the two fields. As an engineering graduate student, his focus is open-source, DIY microfluidics that can help biohackers up their game, and he’ll stop by the Hack Chat to run us through the basics. Come with your questions about how — and why — to build your own microfluidics devices, and find out how modern biohackers are learning to “go with the flow.”

Our Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, July 7 at 12:00 PM Pacific time. If time zones have you tied up, we have a handy time zone converter.

[Featured image: Cooksey/NIST]

Hacked Heating Instruments For The DIY Biology Lab

November 12, 2018 by Dan Maloney 4 Comments

[Justin] from The Thought Emporium takes on a common molecular biology problem with these homebrew heating instruments for the DIY biology lab.

The action at the molecular biology bench boils down to a few simple tasks: suck stuff, spit stuff, cool stuff, and heat stuff. Pipettes take care of the sucking and spitting, while ice buckets and refrigerators do the cooling. The heating, however, can be problematic; vessels of various sizes need to be accommodated at different, carefully controlled temperatures. It’s not uncommon to see dozens of different incubators, heat blocks, heat plates, and even walk-in environmental chambers in the typical lab, all acquired and maintained at great cost. It’s enough to discourage any would-be biohacker from starting a lab.

[Justin] knew It doesn’t need to be that way, though. So he tackled two common devices: the incubator and the heating block. The build used as many off-the-shelf components as possible, keeping costs down. The incubator is dead simple: an insulated plastic picnic cooler with a thermostatically controlled reptile heating pad. That proves to be more than serviceable up to 40°, at the high end of what most yeast and bacterial cultures require.

The heat block, used to heat small plastic reaction vessels called Eppendorf tubes, was a little more complicated to construct. Scrap heat sinks yielded aluminum stock, which despite going through a bit of a machinist’s nightmare on the drill press came out surprisingly nice. Heat for the block is provided by a commercial Peltier module and controller; it looks good up to 42°, a common temperature for heat-shocking yeast and tricking them into taking up foreign DNA.

We’re impressed with how cheaply [Justin] was able to throw together these instruments, and we’re looking forward to seeing how he utilizes them. He’s already biohacked himself, so seeing what happens to yeast and bacteria in his DIY lab should be interesting.

Continue reading “Hacked Heating Instruments For The DIY Biology Lab” →

Carbon Augmented Spider Silk

March 15, 2018 by Brian McEvoy 22 Comments

Some of the creepy-crawlers under our feet, flitting through the air, and waiting on silk webs, incorporate metals into their rigid body parts and make themselves harder. Like Mega Man, they absorb the metals to improve themselves. In addition to making their bodies harder, silk-producing creatures like worms and spiders can spin webs with augmented properties. These silks can be conductive, insulating, or stronger depending on the doping elements.

At Italy’s University of Trento, they are pushing the limits and dosing spiders with single-wall carbon nanotubes and graphene. The carbon is suspended in water and sprayed into the spider’s habitat. After the treatment, the silk is measured, and in some cases, the silk is significantly tougher and surpasses all the naturally occurring fibers.

Commercial spider silk harvesting hasn’t been successful, so maybe the next billionaire is reading this right now. Let’s not make aircraft-grade aluminum mosquitoes though. In fact, here’s a simple hack to ground mosquitoes permanently. If you prefer your insects alive, maybe you also like their sound.

Thank you for the tip, [gippgig].