GPS Tracking In The Trackless Land

October 7, 2024 by Al Williams 17 Comments

Need a weekend project? [Cepa] wanted a GPS tracker that would send data out via LTE or the Iridium network. Ok, maybe that’s one for a very long weekend. However, the project was a success and saw service crossing the Barents Sea in the Arctic. Not bad.

Apparently, [Cepa] is very involved in sharing tracks to odd and remote places. While you may not have cell service in the middle of the Barents Sea, you can always see Iridium. The device does make some sacrifices to the expense of satellite communications. On LTE, the system pings your location every ten seconds. Without it, it dials up the sat connection once an hour. However, it does store data on a SD card, so — presumably — you get caught up when you have a connection.

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Using Donor Immune Cells To Mass-Produce CAR-T Autoimmune Therapies

October 7, 2024 by Maya Posch 3 Comments

As exciting as immunotherapies are in terms of fighting cancer, correcting autoimmune disorders and so on, they come with a major disadvantage. Due to the current procedure involving the use of a patient’s own immune (T) cells, this making such therapies rather expensive and involved for the patient. Recent research has therefore focused on answering the question whether T cells from healthy donors could be somehow used instead, with promising results from a recent study on three human patients, as reported in Nature.

The full study results (paywalled) by [Xiaobing Wang] et al. are published in Cell, with the clinical trial details available on the ClinicalTrials.gov website. For this particular trial the goal was to attempt to cure the autoimmune conditions of the three study participants (being necrotizing myopathy (IMNM) and diffuse cutaneous systemic sclerosis (dcSSc)). The T cells used in the study were obtained from a healthy 21-year old woman, and modified with chimeric antigen receptors targeting B (memory) cells. Using CRISPR-Cas9 the T cells were then further modified to prevent the donor cells from attacking the patient’s cells and vice versa.

After injection, the CAR-T cells got to work, multiplying and seeking out the target B cells, including the pathogenic ones underlying the autoimmune conditions. This persisted for a few weeks until the CAR-T cells effectively vanished and new B cells began to emerge, with a clear decrease in autoantibodies. Two months after beginning treatment, all three participants noted marked improvements in their conditions, which persisted at 6 months. For the woman with IMNM, muscle strength had increased dramatically with undetectable autoantibody levels, and the two men with dcSSc saw scar tissue formation reversed and their skin condition improve massively.

It remains to be seen whether this period of remission in these patients is permanent, and whether there any side effects of CAR-T cell therapy. We previously reported on CAR-T cell therapies and the many promises which they hold. Depending on the outcome of these early trials, it could mean that autoimmune conditions, allergies and cancer will soon be worries of the past, marking another massive medical milestone not unlike the invention of vaccines and the discovery of antibiotics.

The Piezoelectric Glitching Attack

October 7, 2024 by Jenny List 18 Comments

Many readers will be familiar with the idea of a glitching attack, introducing electrical noise into a computer circuit in the hope of disrupting program flow and causing unexpected behaviour which might lead to hitherto unavailable access to memory or other system resources. [David Buchanan] has written a piece investigating glitching attacks on PC memory, and the tool he’s used is the ubiquitous piezoelectric lighter.

Attaching a short piece of wire to one of the lines on a SODIMM memory module, he can glitch a laptop at will with the lighter through the electromagnetic noise its discharge creates. It’s a cool trick, but the real meat of the write-up lies in his comprehensive description of how virtual memory works, and how a glitch can be used to break out of the “sandbox” of memory allocated to a particular process. He demonstrates it in a video which we’ve placed below the break, in which he gains root access and runs an arbitrary piece of code on a Linux laptop. It’s probable that not many of us have the inclination to do this for ourselves, but even so it’s fascinating to know how such an attack works.

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The Turing Machine Made Real, In LEGO

October 7, 2024 by Jenny List 19 Comments

The British mathematician and pioneer of computing Alan Turing published a paper in 1936 which described a Universal Machine, a theoretical model of a computer processor that would later become known as a Turing Machine. Practical computers don’t quite follow the design of a Turing Machine, but if we are prepared to sacrifice its need for an infinitely long paper tape it’s quite possible to build one. This is what [The Bananaman] has done using LEGO as a medium, and if you’d like one for yourself you can even vote for it on the LEGO ideas website.

There’s a video for the project which we’ve placed below, and it goes into quite some detail on the various mechanisms required. Indeed for someone used to physical machinery it’s a better explanation through seeing the various parts than many paper explanations. Not for the first time we’re bowled over by what is possible through the use of the LEGO precision mouldings, this is a machine which would have been difficult and expensive to build in the 1930s by individually machining all its parts.

With just shy of six thousand supporters and a hefty 763 days left at time of writing, there’s plenty of time for it to garner support. But if you want one don’t delay, boost the project by voting for it early.

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JawnCon 0x1 Kicks Off Friday, Tickets Almost Gone

October 7, 2024 by Tom Nardi 3 Comments

Of all nature’s miraculous gifts, few can compare to the experience of witnessing a new hacker con grow. If you’re in the Philadelphia area this weekend, you can get a front-row seat to this rare spectacle as JawnCon moves into its second year.

Running Friday into Saturday at Arcadia University, JawnCon 0x1 promises to be a celebration of technology, with a unique bend towards the glory days of the 80s and 90s — back when screeching noises coming out of the back of your computer was nothing to worry about. With talks that cover resurrecting payphones and spinning up your own AIM (AOL Instant Messenger), to a badge that will let attendees literally dial into an array of early Internet services, hackers of a certain vintage should feel right at home.

No gray beard? No problem. The early Internet theme certainly isn’t meant to exclude the younger players. In fact, quite the opposite. There’s an undeniable benefit to studying the fundamentals of any topic, and just as the 4-bit badge from Supercon 2022 gave many attendees their first taste of programming bare metal, JawnCon 0x1 ticket holders will get the opportunity to study protocols and techniques which you don’t often get a chance to work with these days. How you gonna keep ’em down on the farm after they’ve seen pppd?

As of this writing there are still tickets available, but it’s getting down to the wire so we wouldn’t recommending sitting on that fence for too much longer. Judging by what this team managed to pull off in their first year, we’re confident that JawnCon 0x1 (and beyond) are going to be well worth the trip.

Hack On Self: The Alt-Tab Annihilator

October 7, 2024 by Arya Voronova 43 Comments

Last time, I told you about a simple script I made to collect data about my laptop activity, talked about why collecting data about yourself is a moral imperative, and shared the upgraded script with you alongside my plans for it. Today, I will show you a problem I’ve been tackling, with help of this script and the data it gives, and I also would love to hear your advice on a particular high-level problem I’m facing.

Today’s problem is as old as time – I often can’t focus on tasks I badly need done, even ones I want done for myself. This has been a consistent problem in my life, closing off opportunities, getting me to inadvertently betray my friends and family, hurting my health and well-being, reinforcing a certain sort of learned helplessness, and likely reinforcing itself as it goes, too.

It’s deeply disturbing to sit down fully intending to work on a project, then notice no progress on it hours later, and come to a gut-wrenching realization you’ve had hundreds of such days before – I think this screws with you, on a fundamental level. Over the years, I’ve been squeezing out lessons from this failure mode, making observations, trying out all sorts of advice, in search of a solution.

Join me today in non-invasive brain augmentation and reprogramming, as I continue trying to turn my life around – this time, with help of my laptop, a computer that I already spend a ton of time interfacing with. Ever notice that starting work on a task is often the hardest part of it? It’s the same for me, and I decided to hack away at it.

Staying On Track

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Vehicle-To-Everything: The Looming Smart Traffic Experience

October 7, 2024 by Maya Posch 47 Comments

Much of a car’s interaction with the world around it is still a very stand-alone, analog experience, regardless of whether said car has a human driver or a self-driving computer system. Mark I eyeballs or equivalent computer-connected sensors perceive the world, including road markings, traffic signs and the locations of other road traffic. This information is processed and the car’s speed and trajectory are adjusted to ideally follow the traffic rules and avoid unpleasant conversations with police officers, insurance companies, and/or worse.

An idea that has been kicked around for a few years now has been to use wireless communication between cars and their environment to present this information more directly, including road and traffic conditions, independent from signs placed near or on the road. It would also enable vehicle-to-vehicle communication (V2V), which somewhat like the transponders in airplanes would give cars and other vehicles awareness of where other traffic is hanging out. Other than V2V, Vehicle-to-Everything (V2X) would also include communication regarding infrastructure (V2I), pedestrians (V2P) and an expansive vehicle-to-network (V2N) that gives off strong Ghost in the Shell vibes.

Is this is the future of road traffic? The US Department of Transport (DOT) seems to think that its deployment will be a good thing, but V2X has been stuck in regulatory hurdles. This may now change, with the DOT releasing a roadmap for its deployment.

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