3D Printing Functional Human Brain Tissue For Research Purposes

Graphical summary of the newly developed 3D bioprinting process. (Credit: Yan et al., 2024)
Graphical summary of the newly developed 3D bioprinting process. (Credit: Yan et al., 2024)

The brain is probably the least explored organ, much of which is due to the difficulty of studying it in situ rather than in slices under a microscope. Even growing small organoids out of neurons provide few clues, as this is not how brain tissue is normally organized. A possible breakthrough may have been found here by a group of researchers whose article in Cell Stem Cell details how they created functional human neural tissues using a commercial 3D bioprinter.

As detailed by [Yuanwei Yan] and colleagues in their research article, the issue with previous approaches was that although these would print layers of neurons, they would fail to integrate as in the brain. In the brain’s tissues, we see a wide variety of neurons and supportive cells, all of which integrate in a specific way to form functioning neuron-to-neuron and neuron-to-glial connections with expected neural activity. The accomplishment of this research team is 3D bioprinting of neural tissues with the necessary functional connections.

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Hands On: Bus Pirate 5

If you’ve been involved with electronics and hardware hacking for awhile, there’s an excellent chance you’ve heard of the Bus Pirate. First introduced on the pages of Hackaday back in 2008 by creator Ian Lesnet, the open hardware multi-tool was designed not only as away to easily tap into a wide array of communication protocols, but to provide various functions that would be useful during hardware development or reverse engineering. The Bus Pirate could talk to your I2C and SPI devices, while also being able to measure frequencies, check voltages, program chips, and even function as a logic analyzer or oscilloscope.

Bus Pirate 3, circa 2012

The Bus Pirate provided an incredible number of tools at a hobbyist-friendly price, and it wasn’t long before the device became so popular that it achieved a milestone which only a few hardware hacking gadgets can boast: its sales started to get undercut by cheap overseas clones. Of course, as an open hardware device, this wasn’t really a problem. If other companies wanted to crank out cheap Bus Pirates, that’s fine. It freed Ian up to research a next-generation version of the device.

But it turns out that was easier said than done. It’s around this point that the Bus Pirate enters what might be considered its Duke Nukem Forever phase. It took 15 years to release the sequel to 1996’s Duke Nukem 3D because the state-of-the-art in video games kept changing, and the developers didn’t want to be behind the curve. Similarly, Ian and his team spent years developing and redeveloping versions of the Bus Pirate that utilized different hardware platforms, such as the STM32 and ICE40 FPGA. But each time, there would be problems sourcing components, or something newer and more interesting would be released.

But then in 2021 the Raspberry Pi Pico hit the scene, and soon after, the bare RP2040 chip. Not only were the vast I/O capabilities of the new microcontroller a perfect fit for the Bus Pirate, but the chip was cheap and widely available. Finally, after years of false starts, the Bus Pirate 5 was born.

I was able to grab one of the first all-new Bus Pirates off the production line in January, and have been spending the last week or so playing around with it. While there’s definitely room for improvement on the software side of things, the hardware is extremely promising, and I’m very excited to be see how this new chapter in the Bus Pirate story plays out.

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Canada Bans Flipper Zero Over What It Imagines It Does

Canada’s intent to ban the Flipper Zero wireless tool over car thefts is, on the one hand, an everyday example of poorly researched government action. But it may also be a not-so-subtle peek into the harm misinformation online can cause by leading to said government action.

The Government of Canada recently hosted a national summit on combatting vehicle theft, and Minister of Innovation, Science and Industry François-Philippe Champagne proudly declared immediate actions being taken to ban devices used to steal vehicles by wirelessly bypassing keyless entry, the Flipper Zero being specifically named as one such device.

And yet, defeating a rolling code keyless entry system is a trick a device like the Flipper Zero simply cannot pull off. (What cars have such a system? Any car made in roughly the last thirty years, for a start.)

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EasyThreed K9: The Value In A €72 AliExpress FDM 3D Printer

The hot end of the EasyThreed K9 is actually pretty nifty. (Credit: [Thomas Sanladerer])
The hot end of the EasyThreed K9 is actually pretty nifty. (Credit: [Thomas Sanladerer])
Recently, [Thomas Sanladerer] bought an EasyThreed K9 off AliExpress for a mere €72, netting him an FDM printer with a 10 x 10 x 10 cm build volume. The build plate is unheated, with optional upgrade, and there is no display to interact with the device: just a big multi-function ‘play’ button and five smaller buttons that direct the print head to preset locations above the build plate to allow for build plate leveling using the knobs on each corner. There’s also a ‘home’ button on the back for homing the print head, which pretty much completes the user interface. As the printer comes in a rather small box, the first step is to assemble the parts into something resembling a 3D printer.

What follows is both a mixture of wonder and horror, as the plastic build quality is everything but convincing, while at the same time, the self-contained nature of each of the three axes of the cantilevered design makes for very easy assembly. The print head has a nifty flip-up cover for easy access to the hot end, which makes the best of the anemic 24-watt power supply for the entire printer. A cooling fan with an air duct even provides part cooling, making this print head a contender for the ‘cheap but not terrible’ category. You can check out his full video review below.

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AI’s Existence Is All It Takes To Be Accused Of Being One

New technologies bring with them the threat of change. AI tools are one of the latest such developments. But as is often the case, when technological threats show up, they end up looking awfully human.

Recently, [E. M. Wolkovich] submitted a scientific paper for review that — to her surprise — was declared “obviously” the work of ChatGPT. No part of that was true. Like most people, [E. M. Wolkovich] finds writing a somewhat difficult process. Her paper represents a lot of time and effort. But despite zero evidence, this casual accusation of fraud in a scientific context was just sort of… accepted.

There are several reasons this is concerning. One is that, in principle, the scientific community wouldn’t dream of leveling an accusation of fraud like data manipulation without evidence. But a reviewer had no qualms about casually claiming [Wolkovich]’s writing wasn’t hers, effectively calling her a liar. Worse, at the editorial level, this baseless accusation was accepted and passed along with vague agreement instead of any sort of pushback.

Showing Your Work Isn’t Enough

Interestingly, [Wolkovich] writes everything in plain text using the LaTeX typesetting system, hosted on GitHub, complete with change commits. That means she could easily show her entire change history, from outline to finished manuscript, which should be enough to convince just about anyone that she isn’t a chatbot.

But pondering this raises a very good question: is [Wolkovich] having to prove she isn’t a chatbot a desirable outcome of this situation? We don’t think it is, nor is this an idle question. We’ve seen how even when an artist can present their full workflow to prove an AI didn’t make their art, enough doubt is sown by the accusation to poison the proceedings (not to mention greatly demoralizing the creator in the process.)

Better Standards Would Help

[Wolkovich] uses this opportunity to reflect on and share what this situation indicates about useful change. Now that AI tools exist, guidelines that acknowledge them should be created. Explicit standards about when and how AI tools can be used in the writing process, how those tools should be acknowledged if used, and a process to handle accusations of misuse would all be positive changes.

Because as it stands, it’s hard to see [Wolkovich]’s experience as anything other than an illustration of how a scientific community’s submission and review process was corrupted not by undeclared or thoughtless use of AI but by the simple fact that such tools exist. This seems like both a problem that will only get worse with time (right now, it is fairly easy to detect chatbots) and one that will not solve itself.

Target Lifting Mechanism Goes Wireless

“WARNING: DO NOT Hammer on this mechanism” sounds like the start of a side quest. A quest is exactly what [CelGenStudios] started when he came upon a strange box with this message.

The military identification tag was printed “Target Holding Mechanism, M31A1”, along with some other information. It also informed the reader that the device weighed 70lbs (31.75kg). Something carrying that much mass just had to be good.

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Hackaday Links: February 11, 2024

Apple’s Vision Pro augmented reality goggles made a big splash in the news this week, and try as we might to resist the urge to dunk on them, early adopters spotted in the wild are making it way too easy. Granted, we’re not sure how many of these people are actually early adopters as opposed to paid influencers, but there was still quite a bit of silliness to be had, most of it on X/Twitter. We’d love to say that peak idiocy was achieved by those who showed themselves behind the wheels of their Teslas while wearing their goggles, with one aiming for an early adopter perfecta, but alas, most of these stories appear to be at least partially contrived. Some people were spotted doing their best to get themselves killed, others were content to just look foolish, especially since we’ve heard that the virtual keyboard is currently too slow for anything but hunt-and-peck typing, which Casey Niestat seemed to confirm with his field testing. After seeing all this, we’re still unsure why someone would strap $4,000 worth of peripheral-vision-restricting and easily fenced hardware to their heads, but hey — different strokes. And for those of you wondering why these things are so expensive, we’ve got you covered.

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