Pufferfish Venom Can Kill, Or It Can Relieve Pain

December 15, 2025 by 21 Comments

Tetrodotoxin (TTX) is best known as the neurotoxin of the puffer fish, though it also appears in a range of other marine species. You might remember it from an episode of The Simpsons involving a poorly prepared dish at a sushi restaurant. Indeed, it’s a potent thing, as ingesting even tiny amounts can lead to death in short order.

Given its fatal reputation, it might be the last thing you’d expect to be used in a therapeutic context. And yet, tetrodotoxin is proving potentially valuable as a treatment option for dealing with cancer-related pain. It’s a dangerous thing to play with, but it could yet hold promise where other pain relievers simply can’t deliver. Continue reading “Pufferfish Venom Can Kill, Or It Can Relieve Pain” →

Tearing Down Walmart’s $12 Keychain Camera

December 15, 2025 by 45 Comments

Keychain cameras are rarely good. However, in the case of Walmart’s current offering, it might be worse than it’s supposed to be. [FoxTailWhipz] bought the Vivitar-branded device and set about investigating its claim that it could deliver high-resolution photos.

The Vivatar Retro Keychain Camera costs $12.88, and wears “FULL HD” and “14MP” branding on the packaging. It’s actually built by Sakar International, a company that manufactures products for other brands to license. Outside of the branding, though, [FoxTailWhipz] figured the resolution claims were likely misleading. Taking photos quickly showed this was the case, as whatever setting was used, the photos would always come out at 640 x 480, or roughly 0.3 megapixels. He thus decided a teardown would be the best way to determine what was going on inside. You can see it all in the video below.

Pulling the device apart was easy, revealing that the screen and battery are simply attached to the PCB with double-sided tape. With the board removed from the case, the sensor and lens module are visible, with the model number printed on the flex cable. The sensor datasheet tells you what you need to know. It’s a 2-megapixel sensor, capable of resolutions up to 1632 x 1212. The camera firmware itself seems to not even use the full resolution, since it only outputs images at 640 x 480.

It’s not that surprising that an ultra-cheap keychain camera doesn’t meet the outrageous specs on the box. At the same time, it’s sad to see major retailers selling products that can’t do what they say on the tin. We see this problem a lot, in everything from network cables to oscilloscopes.

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A Brief History Of The Spreadsheet

December 15, 2025 by 58 Comments

We noted that Excel turned 40 this year. That makes it seem old, and today, if you say “spreadsheet,” there’s a good chance you are talking about an Excel spreadsheet, and if not, at least a program that can read and produce Excel-compatible sheets. But we remember a time when there was no Excel. But there were still spreadsheets. How far back do they go? Continue reading “A Brief History Of The Spreadsheet” →

Mass Spectrometer Tear Down

December 15, 2025 by 6 Comments

If you have ever thought, “I wish I could have a mass spectrometer at home,” then we aren’t very surprised you are reading Hackaday. [Thomas Scherrer] somehow acquired a broken Brucker Microflex LT Mass Spectrometer, and while it was clearly not working, it promised to be a fun teardown, as you can see in the first part of the video below.

Inside are lasers and definitely some high voltages floating around. This appears to be an industrial unit, but it has a great design for service. Many of the panels are removable without tools.

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All-Screen Keyboard Has Flexible Layouts

December 15, 2025 by 27 Comments

Most keyboards are factory-set for a specific layout, and most users never change from the standard layout for their home locale. As a multilingual person, [Inkbox] wanted a more flexible keyboard. In particular, one with the ability to change its layout both visually and logically, on the fly. Thus was born the all-screen keyboard, which can swap layouts on demand. Have a look at the video below to see the board in action.

The concept is simple enough: It’s a keyboard with transparent keys and a screen underneath. The screen displays the labels for the keys, while the transparent plastic keys provide the physical haptic interface for the typist. The device uses a Raspberry Pi to drive the screen. [Inkbox] then designed a plastic frame and transparent keys, which are fitted with magnets, which in turn are read by Hall effect sensors under the display. This eliminates the need for traditional key switches, which would block light from the screen below.

Unfortunately for [Inkbox], the prototype was very expensive (about $1,400 USD) and not particularly functional as a keyboard. However, a major redesign tackled some of these issues. Version two had a smaller screen with a different aspect ratio. It also jettisoned the Hall effect sensors and uses plastic keys capacitively operating a traditional touch screen. Some design files for the keyboard are available on Github for the curious.

An all-screen keyboard is very cool, if very complicated to implement. There are other ways to change your layout that aren’t quite as fancy, of course. You can always just make custom keycaps and remap layouts on a regular mechanical keyboard if desired. Still, you have to admire the work that went into making this thing a reality.

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Hackaday Links: December 14, 2025

December 14, 2025 by 7 Comments

Fix stuff, earn big awards? Maybe, if this idea for repair bounties takes off. The group is dubbed the FULU Foundation, for “Freedom from Unethical Limitations on Users,” and was co-founded by right-to-repair activist Kevin O’Reilly and perennial Big Tech thorn-in-the-side Louis Rossman. The operating model works a bit like the bug bounty system, but in reverse: FULU posts cash bounties on consumer-hostile products, like refrigerators that DRM their water filters or bricked thermostats. The bounty starts at $10,000, but can increase based on donations from the public. FULU will match those donations up to $10,000, potentially making a very rich pot for the person or team that fixes the problem.

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A graph showing the poisoning success rate of 7B and 13B parameter models

It Only Takes A Handful Of Samples To Poison Any Size LLM, Anthropic Finds

December 14, 2025 by 98 Comments

It stands to reason that if you have access to an LLM’s training data, you can influence what’s coming out the other end of the inscrutable AI’s network. The obvious guess is that you’d need some percentage of the overall input, though exactly how much that was — 2%, 1%, or less — was an active research question. New research by Anthropic, the UK AI Security Institute, and the Alan Turing Institute shows it is actually a lot easier to poison the well than that.

We’re talking parts-per-million of poison for large models, because the researchers found that with just 250 carefully-crafted poison pills, they could compromise the output of any size LLM. Now, when we say poison the model, we’re not talking about a total hijacking, at least in this study. The specific backdoor under investigation was getting the model to produce total gibberish.

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