Analyzing The “Source Code” Of The COVID-19 Vaccine

December 26, 2020 by Lewin Day 54 Comments

Computer programs are written in code, which comes in many forms. At the lowest level, there’s machine code and assembly, while higher-level languages like C and Python aim to be more human-readable. However, the natural world has source code too, in the form of DNA and RNA strings that contain the code for the building blocks of life. [Bert] decided to take a look at the mRNA source code of Tozinameran, the COVID-19 vaccine developed by BioNTech and Pfizer.

The analysis is simple enough for the general reader, while nonetheless explaining some highly complex concepts at the cutting edge of biology. From codon substitutions for efficiency and the Ψ-base substitution to avoid the vaccine being destroyed by the immune system, to the complex initialisation string required at the start of the RNA sequence, [Bert] clearly explains the clever coding hacks that made the vaccine possible. Particularly interesting to note is the Prolase substitution, a technique developed in 2017. This allows the production of coronavirus spike proteins in isolation of the whole virus, in order to safely prime the immune system.

It’s a great primer and we can imagine it might inspire some to delve further into the rich world of genetics and biology. We’ve featured other cutting edge stories on COVID-19 too; [Dan Maloney] took a look at how CRISPR techniques are helping with the testing effort. If there’s one thing the 2020 pandemic has shown, it’s humanity’s ability to rapidly develop new technology in the face of a crisis.

Automatic Sanitizer For Your Cupholder

December 16, 2020 by Kristina Panos 6 Comments

Why is it so hard to remember to use hand sanitizer between going into the store and driving back home? We tried hanging a bottle off the windshield wiper stalk, but it gets in the way and is hard to use and share with passengers. The ideal thing would be to have a hands-free pump in the car that reminds you to use it.

You don’t have to wire this to the ignition or anything — all you have to do is power it with the cigarette lighter (or straight-up outlet, if you’re lucky). Every time you turn the key, this pump powers up and performs a little song to remind you to use it. Electronically speaking, it couldn’t be simpler — an Arduino UNO reads your hand from the distance sensor and activates a servo that dispenses three short pumps of isopropyl alcohol. Check it out in action after the break.

Want a hands-free solution for the house? Just build something you can step on.

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The Special Fridges Behind The COVID-19 Vaccine, Why It’s Surprisingly Difficult To Be That Cool

November 17, 2020 by Jenny List 162 Comments

One of the big stories last week was the announcement of results from clinical trials that suggest a new COVID-19 vaccine developed through the joint effort of the American and German companies Pfizer and BioNTech is strongly effective in providing immunity from the virus. In the midst of what is for many countries the second spike of the global pandemic this news has been received with elation as well as becoming the subject of much political manoeuvring.

While we currently have two vaccine candidates with very positive testing results, one of the most interesting things for us is the need to keep doses of the Pfizer/BioNTech vaccine extremely cold until they are administered. Let’s dig into details of the refrigeration problem at hand.

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Door Mutes Microphone To Prevent Remote Learning Humiliation

November 8, 2020 by Chris Lott 16 Comments

In a kind of reverse twist on the doorbell, [TheStaticTurtle] whipped up a system to mute his computer’s microphone whenever someone opens the door to his room. He lives in France, where the government announced a strict lockdown last Friday. Like many university students around the world these days, he is now forced to take online classes. Even though he has his own room, occasionally someone will barge in and announce something, often to [TheStaticTurtle]’s embarrassment. When his classmates suddenly heard “Do you want some pie?” the other day, it was the last straw.

His first decision was to sense the door opening with a magnet and sensor, which he stuck to the door and frame with hot glue. He then ran a long cable to his desk, where it connected to an ATTiny 85 with a DigiSpark boot-loader. He wrote firmware to simulate special key combinations, which were then registered with his audio routing software Voicemeeter Potato. We presume he isn’t using an external mic, in which case muting might have been easier to accomplish with a hardware switch. All in all, this is a pretty clever and timely hack. Should you be in a similar predicament and want to try this out, he’s published the source code on GitHub.

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COVID-tracing Framework Privacy Busted By Bluetooth

September 3, 2020 by Elliot Williams 60 Comments

[Serge Vaudenay] and [Martin Vuagnoux] released a video yesterday documenting a privacy-breaking flaw in the Apple/Google COVID-tracing framework, and they’re calling the attack “Little Thumb” after a French children’s story in which a child drops pebbles to be able to retrace his steps. But unlike Hänsel and Gretl with the breadcrumbs, the goal of a privacy preserving framework is to prevent periodic waypoints from allowing you to follow anyone’s phone around. (Video embedded below.)

The Apple/Google framework is, in theory, quite sound. For instance, the system broadcasts hashed, rolling IDs that prevent tracing an individual phone for more than fifteen minutes. And since Bluetooth LE has a unique numeric address for each phone, like a MAC address in other networks, they even thought of changing the Bluetooth address in lock-step to foil would-be trackers. And there’s no difference between theory and practice, in theory.

In practice, [Serge] and [Martin] found that a slight difference in timing between changing the Bluetooth BD_ADDR and changing the COVID-tracing framework’s rolling proximity IDs can create what they are calling “pebbles”: an overlap where the rolling ID has updated but the Bluetooth ID hasn’t yet. Logging these allows one to associate rolling IDs over time. A large network of Bluetooth listeners could then trace people’s movements and possibly attach identities to chains of rolling IDs, breaking one of the framework’s privacy guarantees.

This timing issue only affects some phones, about half of the set that they tested. And of course, it’s only creating a problem for privacy within Bluetooth LE range. But for a system that’s otherwise so well thought out in principle, it’s a flaw that needs fixing.

Why didn’t the researchers submit a patch? They can’t. The Apple/Google code is mostly closed-source, in contrast to the open-source nature of most of the apps that are running on it. This remains troubling, precisely because the difference between the solid theory and the real practice lies exactly in those lines of uninspectable code, and leaves all apps that build upon them vulnerable without any recourse other than “trust us”. We encourage Apple and Google to make the entirety of their COVID framework code open. Bugs would then get found and fixed, faster.

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Fog-Free Mask Hack Solves Mask Versus Glasses Conundrum With Superb Seal

September 2, 2020 by Brian McEvoy 35 Comments

If you have worn a mask and glasses together for more than a quarter of a second, you are probably annoyed that we don’t have a magical solution for foggy lenses. Moisture-laden air is also a good indicator of where unfiltered air is escaping. Most masks have some flexible metal across the nose bridge that is supposed to seal the top, but it is woefully inadequate. The Badger Seal by [David Rothamer] and [Scott Sanders] from the University of Wisconsin-Madison College of Engineering is free to copy during the COVID-19 pandemic, even commercially. It works by running an elastic cord below the jaw and a formable wire over the nose to encourage contact all around both mouth and nose.

You can build your own in three ways. Each configuration is uniquely suited to a different situation. The first design is the easiest to make and should work for most people. The second is best for folks who need a better seal on the lower half of their face, like someone sporting a beard. It can also have ear loops, and that means your 3D printed ear savers have another use. The Madison campus of the University of Wisconsin also has fun with lock cracking and graphene experiments.
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Building A Heavy Duty Open Source Ventilator

August 28, 2020 by Tom Nardi 12 Comments

Since the COVID-19 pandemic started, we’ve seen several attempts to create homebrew ventilators designed to address the shortage of these lifesaving machines. Unfortunately, most hackers aren’t terribly experienced when it comes to designing practical medical equipment. So while many of the designs might have appeared functional on the workbench, there’s little chance they’d get used in any official capacity.

The open source DP Ventilator is still clearly the product of a couple plucky hackers, but we think it shows a level of design maturity that’s been missing in many of the earlier attempts. Made primarily with 3D printed components, this mechanical device is designed to operate a hand-held manual resuscitator; essentially standing in for a human operator. This makes the design far less complex than if it had to actually pump air itself, not to mention safer for the patient since the resuscitator (often referred to as an Ambu Bag) installed in it would be a sterile pre-packaged item.

In the video after the break, you can see just how much thought and effort has been put into the device’s touch screen interface. With a few quick taps the medical professional operating the DP Ventilator can dial in variables such as breathing rate, pressure, and volume to match the patient’s needs. While the Arduino Mega 2560 at the machine’s heart wouldn’t pass muster for any regulating body in charge of medical devices, we think with a few more tweaks, this design is getting close to something that might actually be able to save lives.

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