Kathleen Lonsdale Saw Through The Structure Of Benzene

June 29, 2021 by Kristina Panos 14 Comments

The unspoken promise of new technologies is that they will advance and enhance our picture of the world — that goes double for the ones that are specifically designed to let us look closer at the physical world than we’ve ever been able to before. One such advancement was the invention of X-ray crystallography that let scientists peer into the spatial arrangements of atoms within a molecule. Kathleen Lonsdale got in on the ground floor of X-ray crystallography soon after its discovery in the early 20th century, and used it to prove conclusively that the benzene molecule is a flat hexagon of six carbon atoms, ending a decades-long scientific dispute once and for all.

Benzene is an organic chemical compound in the form of a colorless, flammable liquid. It has many uses as an additive in gasoline, and it is used to make plastics and synthetic rubber. It’s also a good solvent. Although the formula for benzene had been known for a long time, the dimensions and atomic structure remained a mystery for more than sixty years.

Kathleen Lonsdale was a crystallography pioneer and developed several techniques to study crystal structures using X-rays. She was brilliant, but she was also humble, hard-working, and adaptable, particularly as she managed three young children and a budding chemistry career. At the outbreak of World War II, she spent a month in jail for reasons related to her staunch pacifism, and later worked toward prison reform, visiting women’s prisons habitually.

After the war, Kathleen traveled the world to support movements that promote peace and was often asked to speak on science, religion, and the role of women in science. She received many honors in her lifetime, and became a Dame of the British Empire in 1956. Before all of that, she honored organic chemistry with her contributions.

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Tiny Tesla Valves Etched In Glass

June 20, 2021 by Bryan Cockfield 8 Comments

While it’s in vogue right now to name fancy new technology after Tesla, the actual inventor had plenty of his own creations that would come to bear his namesake, including Tesla coils, Tesla oscillators, Tesla turbines and even the infamous Tesla tower. One of the lesser known inventions of his is the Tesla valve, a check valve that allows flow in one direction without any moving parts, and [Huygens Optics] shows us a method of etching tiny versions of these valves into glass.

The build starts out with a fairly lengthy warning, which is standard practice when working with hydroflouric acid. The acid is needed to actually perform the etching, but it’s much more complicated than a typical etch due to the small size of the Tesla valves. He starts by mixing a buffered oxide etch, a mix of the hydroflouric acid, ammonia, and hydrochloric acid, which gives a much more even etching than any single acid alone. Similar to etching PCBs, a protective mask is needed to ensure that the etch only occurs where it’s needed. For that there are several options, each with their own benefits and downsides, but in the end [Huygens Optics] ends up with one of the smallest Tesla valves ever produced.

In fact, the valves are so small that they can only be seen with the aid of a microscope. While viewing them under the microscope he was able to test with a small drop of water to confirm that they do work as intended. And, while the valves that he is creating in this build are designed to work on liquids, [Huygens Optics] notes that the reason for making them this small was to make tiny optical components which they are known for.

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Alice Ball Steamrolled Leprosy

June 15, 2021 by Kristina Panos 22 Comments

Leprosy is a bacterial disease that affects the skin, nerves, eyes, and mucosal surfaces of the upper respiratory tract. It is transmitted via droplets and causes skin lesions and loss of sensation in these regions. Also known as Hansen’s disease after the 19th century scientist who discovered its bacterial origin, leprosy has been around since ancient times, and those afflicted have been stigmatized and outcast for just as long. For years, people were sent to live the rest of their days in leper colonies to avoid infecting others.

The common result of injecting chaulmoogra oil. Image via Stanford University

Until Alice Ball came along, the only thing that could be done for leprosy — injecting oil from the seeds of an Eastern evergreen tree — didn’t really do all that much to help. Eastern medicine has been using oil from the chaulmoogra tree since the 1300s to treat various maladies, including leprosy.

The problem is that although it somewhat effective, chaulmoogra oil is difficult to get it into the body. Ingesting it makes most people vomit. The stuff is too sticky to be applied topically to the skin, and injecting it causes the oil to clump in abscesses that make the patients’ skin look like bubble wrap.

In 1866, the Hawaiian government passed a law to quarantine people living with leprosy on the tiny island of Moloka’i. Every so often, a ferry left for the island and delivered these people to their eventual death. Most patients don’t die of leprosy, but from secondary infection or disease. By 1915, there were 1,100 people living on Moloka’i from all over the United States, and they were running out of room. Something had to be done.

Professor Alice Ball hacked the chemistry of chaulmoogra oil and made it less viscous so it could be easily injected. As a result, it was much more effective and remained the ideal treatment until the 1940s when sulfate antibiotics were discovered. So why haven’t you heard of Alice before? She died before she could publish her work, and then it was stolen by the president of her university. Now, over a century later, Alice is starting to get the recognition she deserves.

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Open-Source Method Makes Possible Two-Layer PCBs With Through-Plating At Home

June 11, 2021 by Dan Maloney 39 Comments

If the last year and its supply chain problems have taught us anything, it’s the value of having a Plan B, even for something as commoditized as PCB manufacturing has become. If you’re not able to get a PCB made commercially, you might have to make one yourself, and being able to DIY a dual-layer board with plated-through vias might just be a survival skill worth learning.

Granted, [Hydrogen Time]’s open-source method, which he calls “Process 01”, is something that he has been working on for years now. And it’s quite the feat of chemistry, which may require you to climb a steep learning curve, depending on how neglected the skills from high school or college chemistry are. But for as complex as Process 01 is, it’s actually pretty straightforward, and the first video below covers it in extreme detail. It starts with a drilled double-sided copper-clad board, which after cleaning is given a bath in palladium chloride. A follow-up dunk in stannous chloride leaves a thin film of palladium metal over all surfaces, even the via walls. This then acts as a catalyst for electroless copper plating in a solution of copper sulfate, followed by an actual electroplating step to thicken the copper plating.

After more washing, photoresist is applied to define the traces as well as to protect the now-plated vias, the board is etched, and a solder mask layer is applied. The boards might not be mistaken for commercial PCBs, but they’re pretty darn good, and as [Hydrogen Time] states, Process 01 is only a beginning. We expect this will be improved and streamlined as time goes by.

Fair warning, though — some steps require a fume hood to be performed safely. Luckily, we’ve got that covered. Sort of.

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Injection-Molded Glass Breakthrough Shatters Ceiling Of Work Methods

June 10, 2021 by Kristina Panos 36 Comments

Glass is one of humanity’s oldest materials, and it is still used widely for everything from drinking vessels and packaging to optics and communications. Unfortunately, the methods for working with glass are stuck in the past. Most methods require a lot of high heat in the range of 1500 °C to 2000 °C, and they’re all limited in the complexity of shapes that can be made.

As far as making shapes goes, glass can be blown and molten glass pressed into molds. Glass can also be ground, etched, or cast in a kiln. Glass would be fantastic for many applications if it weren’t for the whole limited geometry thing. Because of the limitations of forming glass, some optic lenses are made with polymers, even though glass has better optical characteristics.

Ideally, glass could be injection molded like plastic. The benefits of this would be twofold: more intricate shapes would be possible, and they would have a much faster manufacturing time. Well, the wait is over. Researchers at Germany’s University of Freiburg have figured out a way to apply injection molding to glass. And it’s not just any glass — they’ve made highly-quality, transparent fused quartz glass, and they did it at lower temperatures than traditional methods. The team used x-ray diffraction to verify that the glass is amorphous and free of crystals, and were able to confirm its optical transparency three ways — light microscopy, UV-visible, and infrared measurements. All it revealed was a tiny bit of dust, which is to be expected outside of a clean room.

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Trials Begin For Lozenge That Rebuilds Tooth Enamel

June 2, 2021 by Kristina Panos 48 Comments

For all the cool regenerative tricks the human body can do, it’s kind of weird that we only have one shot at tooth enamel with no way to get it back. That may be about to change, as researchers at the University of Washington have developed a lozenge that rebuilds this precious protective coating a few microns at a time and are taking it to the trial stage. Could it really work? It’s certainly something to chew on.

The lozenge uses a genetically-engineered peptide (a chain of amino acids) derived from a protein that’s involved in developing enamel in the first place, as well as with the formation of the root surface of teeth. Inside the lozenge, this peptide works alongside phosphorus and calcium ions, which are the building blocks of tooth enamel. It’s designed to bind to damaged enamel without harming the gums, tongue, or other soft tissues of the mouth.

The researchers have already verified the efficacy on teeth extracted from humans, pigs, and rats, so the trials will largely revolve around comparing it to other whitening methods and documenting their findings.

One added advantage is that the new enamel the lozenges produce is really white, because it’s brand new. These lozenges sound like an all-around great solution, especially compared with traditional whitening techniques that often make enamel weaker. The researchers are also developing an over-the-counter toothpaste and some kind of solution for hypersensitivity, which is right up our alley.

We are skeptical of course, because nothing in history thus far has been able to regenerate enamel. Then again, yours truly uses toothpaste with nano-hydroxyapatite, which is touted as a non-toxic version of the same mineral that makes up teeth and bones. Skepticism abounds with that stuff, too, although my grill looks better to me. But why settle for new enamel when you could regrow entire teeth?

Main image by Eric Moreau and thumbnail image by Kevin Bation via Unsplash

Thin Coatings Require An Impressive Collection Of Equipment And Know-How

May 31, 2021 by Dan Maloney 15 Comments

Let’s be honest — not too many of us have a need to deposit nanometer-thick films onto substrates in a controlled manner. But if you do find yourself in such a situation, you could do worse than following [Jeroen Vleggaar]’s lead as he builds out a physical vapor deposition apparatus to do just that.

Thankfully, [Jeroen] has particular expertise in this area, and is willing to share it. PVD is used to apply an exceedingly thin layer of metal or organic material to a substrate — think lens coatings or mirror silvering, as well as semiconductor manufacturing. The method involves heating the coating material in a vacuum such that it vaporizes and accumulates on a substrate in a controlled fashion. Sounds simple, but the equipment and know-how needed to actually accomplish it are daunting. [Jeroen]’s shopping list included high-current power supplies to heat the coating material, turbomolecular pumps to evacuate the coating chamber, and instruments to monitor the conditions inside the chamber. Most of the chamber itself was homemade, a gutsy move for a novice TIG welder. Highlights from the build are in the video below, which also shows the PVD setup coating a glass disc with a thin layer of silver.

This build is chock full of nice details; we especially liked the technique of monitoring deposition progress by measuring the frequency change of an oscillator connected to a crystal inside the chamber as it accumulates costing material. We’re not sure where [Jeroen] is going with this, but we suspect it has something to do with some hints he dropped while talking about his experiments with optical logic gates. We’re looking forward to seeing if that’s true.

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