Before the SARS-CoV-2 pandemic took hold, few people were aware of the existence of mRNA vaccines. Yet after months of vaccinations from Moderna and BioNTech and clear indications of robust protection to millions of people, it now seems hard to imagine a world without mRNA vaccine technology, especially as more traditional vaccines seem to falter against the new COVID-19 variants and the ravages of so-called ‘Long COVID’ become more apparent.
Yet, it wasn’t that long ago that Moderna and BioNTech were merely a bunch of start-ups, trying to develop profitable therapies for a variety of diseases, using the brand-new and largely unproven field of RNA therapeutics. Although the use of mRNA in particular for treatments has been investigated since 1989, even as recently as 2017 there were still many questions about safe and effective ways to deliver mRNA into cells, as per Khalid A. Hajj et al.
Clearly those issues have been resolved now in 2021, which makes one wonder about the other exciting possibilities that mRNA delivery offers, from vaccines for malaria, cancer, HIV, as well as curing autoimmune diseases. How did the field of mRNA vaccines develop so quickly, and what can we expect to see the coming years?
There I was, thirty years after I first sat down at an Apple IIe , and I suddenly found myself wondering if I would ever use a computer again without pain. How could I work if I couldn’t use a computer anymore? I had to seriously ask myself this question. It took a bit of a winding road to figure out what was going on and two EMGs to confirm it, but after all these years, it was clear to the medical community that I had developed a repetitive stress injury (RSI) called cubital tunnel syndrome in my left arm.
Cubital tunnel syndrome is like carpal tunnel, but in your elbow instead of your wrist. What a misnomer! Sometimes my pain went all the way from my armpit to my fingertips and made me want to gnaw my own arm off. I don’t think you can really understand neuropathy unless you’ve felt this weird, annoying type of pain firsthand. I hope you never do.
Can you stop and seriously imagine not being able to use a computer for the rest of your life? Or at least feeling that way because doing so causes incredibly annoying pain? I feel like we’re all vaguely aware of the standard list of anti-RSI precautions, but let’s review:
maintain good posture — sit with feet flat on the floor, wrists straight, elbows at 90°
put the screen an arm’s length away at eye level
take frequent short breaks
Yes, those are all fine and good. But there are other things you can do to avoid computer-related RSIs, like using ergonomic inputs, and building a custom setup that fits you exactly. This isn’t a study kiosk at the university library we’re talking about — this is your battlestation! The problem is that many people are stubborn, and won’t go out of their way to do anything to proactively prevent these injuries. But you don’t have to cross a bridge when you come to it if you have a map that shows you a way around the body of water.
Blurring is a commonly used visual effect when digitally editing photos and videos. One of the most common blurs used in these fields is the Gaussian blur. You may have used this tool thousands of times without ever giving it greater thought. After all, it does a nice job and does indeed make things blurrier.
Do you ever wonder how much of what we do you could figure out from scratch? Tying your shoe might seem simple now, but kids have trouble mastering the skill, and dreaming it up for the first time is even harder. The same holds true for a lot of technology we use every day. Would you think up the computer mouse or even the computer if they didn’t already exist? Surely, though, one of the simplest and most useful math equations that is fundamental to electronics — Ohm’s law — would be easy to figure out, right? It is often the first thing you learn about electronics, but figuring it out that first time turned out to be quite difficult.
The fellow who discovered the relationship was Georg Ohm, a high school math and physics teacher from Köln. What you might not know is that the first time he published it, he got it wrong. But, lucky for us, he figured out his mistake and was able to correct it.
Just a few weeks before Atlantis embarked on the final flight of the Space Shuttle program in 2011, a small Mexican company by the name of Squad quietly released Kerbal Space Program (KSP) onto an unsuspecting world. Until that point the company had only developed websites and multi-media installations. Kerbal wasn’t even an official company initiative, it started as a side project by one of their employees, Felipe Falanghe. The sandbox game allowed players to cobble together rockets from an inventory of modular components and attempt to put them into orbit around the planet Kerbin. It was immediately addictive.
There was no story to follow, or enemies to battle. The closest thing to a score counter was the altimeter that showed how far your craft was above the planet’s surface, and the only way to “win” was to put its little green occupant, the titular Kerbal, back on the ground in one piece. The game’s challenge came not from puzzles or scripted events, but from the game’s accurate (if slightly simplified) application of orbital mechanics and Newtonian dynamics. Building a rocket and getting it into orbit in KSP isn’t difficult because the developers baked some arbitrary limitations into their virtual world; the game is hard for the same reasons putting a rocket into orbit around the Earth is hard.
One of my early rockets, circa 2013.
Over the years official updates added new components for players to build with and planets to explore, and an incredible array of community developed add-ons and modifications expanded the scope of the game even further. KSP would go on to be played by millions, and seeing a valuable opportunity to connect with future engineers, both NASA and the ESA helped develop expansions for the game that allowed players to recreate their real-world vehicles and missions.
But now after a decade of continuous development, with ports to multiple operating systems and game consoles, Squad is bringing this chapter of the KSP adventure to a close. To celebrate the game’s 10th anniversary on June 24th, they released “On Final Approach”, the game’s last official update. Attention will now be focused on the game’s ambitious sequel, which will expand the basic formula with the addition of interstellar travel and planetary colonies, currently slated for release in 2022.
Of course, this isn’t the end. Millions of “classic” KSP players will still be slinging their Kerbals into Hohmann transfer orbits for years to come, and the talented community of mod developers will undoubtedly help keep the game fresh with unofficial updates. But the end of official support is a major turning point, and it seems a perfect time to reminisce on the impact this revolutionary game has had on the engineering and space communities.
Gripped as we are at the time of this writing by a historic heatwave, it’s hard for those of us in the western United States to picture a time when cold and ice reigned across the land. But really, it was only about four months back that another bit of freakish weather was visited across most of the country, including places ill-equipped to deal with the consequences. The now-fabled “February Freeze” left millions, mostly in Texas, scrabbling about in the dark and cold as a series of cascading engineering failures took apart their electrical grid, piece by piece, county by county.
The event has been much discussed and dissected, as an event with such far-reaching impact should be. Like much discussion these days, precious little of it is either informed or civil, and that’s not good news for those seeking to understand what happened and how to prevent it from happening again, or at least to mitigate the effects somewhat. Part of that is understandable, given the life-disrupting and often life-threatening situations the disaster forced people to suddenly face. It’s also difficult for people to discuss an event so widespread in its scope and impact — there’s just too much for anyone to wrap their head around.
To make the present discussion a little easier, we’ll be focusing on one aspect of the February grid crash that’s often bandied about but rarely explained: that the Texas grid was mere minutes away from collapsing completely, and that it would have taken weeks or months to restore had it been able to slip away. Is that really possible? Can the power grid just “go away” completely and suddenly? The answer, sadly, is yes, but thankfully a lot of thought has been put into not only preventing it from happening but also how to restart everything if it does happen, by performing what’s known as a “Black Start.”
Spend enough time on the automotive classifieds and you’ll end up finding a deal that’s too good to pass up. The latest of these in one’s own case was a Mercedes-Benz sedan, just past its twentieth birthday and in surprisingly tidy condition. At less than $3,000, the 1998 E240 was too good to pass up and simply had to be seen.
The car in question. Clean bodywork is too tempting to resist, even if there are mechanical issues.
The car was clean, too clean for asking price. Of course, a test drive revealed the car had one major flaw – an annoying hum from the drivetrain that seemed to vary with speed. Overall though, mechanical problems are often cheaper and easier to fix than bodywork, so a gamble was taken on the German sedan. The first order of business was to diagnose and rectify the issue.
Characterise, Research, Investigate
The first step to hunting down any noise is to characterise it as much as possible. In this case, the noise was most noticeable when the car was traveling at speeds from 40 km/h – 60 km/h, present as a vibrational humming noise. The location of the noise source was unclear. Importantly, the noise varied with the speed of the car, raising in pitch at higher speeds and dropping as speeds decreased. Engine speed had no effect on noise whatsoever, and the noise was present regardless of gear selected in the transmission, including neutral. Continue reading “The Case Of The Mysterious Driveline Noise”→
