Coronavirus Testing: CRISPR Technology Set To Streamline Viral Testing

If we could run back 2020 to its beginning and get a do-over, chances are pretty good that we’d do a lot of things differently. There’s a ton of blame to go around on COVID-19, but it’s safe to say that one of the biggest failures of this whole episode has been the lack of cheap, quick, accurate testing for SARS-CoV-2, the virus behind the current pandemic. It’s not for lack of information; after all, Chinese scientists published the sequence of the viral genome very early in the pandemic, and researchers the world over did the same for all the information they gleaned from the virus as it rampaged around the planet.

But leveraging that information into usable diagnostics has been anything but a smooth process. Initially, the only method of detecting the virus was with reverse transcriptase-polymerase chain reaction (RT-PCR) tests, a fussy process that requires trained technicians and a well-equipped lab, takes days to weeks to return results, and can only tell if the patient has a current infection. Antibody testing has the potential for a quick and easy, no-lab-required test, but can only be used to see if a patient has had an infection at some time in the past.

What’s needed as the COVID-19 crisis continues is a test with the specificity and sensitivity of PCR combined with the rapidity and simplicity of an antibody test. That’s where a new assay, based on the latest in molecular biology methods and dubbed “STOPCovid” comes in, and it could play a major role in diagnostics now and in the future.

Continue reading “Coronavirus Testing: CRISPR Technology Set To Streamline Viral Testing”

Teardown: Nabaztag

In 2020 there is nothing novel or exciting about an online device. Even the most capable models are designed to be unobrusive pucks and smart speakers; their function lies in what they do rather than in how they look. In 2005, an Internet connected device was a rare curiosity, a daring symbol of a new age: the “Internet of Things”!

Our fridges were going to suggest recipes based upon their contents, and very few people had yet thought of the implications of an always-on connected appliance harvesting your data on behalf of a global corporation. Into this arena stepped the Nabaztag (from the Armenian for “rabbit”), an information appliance in the form of a stylised French plastic rabbit that could deliver voice alerts, and indicate status alerts by flashing lights and moving its ears.

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2020 Hackaday Prize Hack Chat With Majenta Strongheart

Join us on Wednesday, May 27 at noon Pacific for the 2020 Hackaday Prize Hack Chat with Majenta Strongheart!

It hardly seems possible, but the Hackaday Prize, the world’s greatest hardware design contest, is once more at hand. But the world of 2020 is vastly different than it was last year, and the challenges we all suddenly face have become both more numerous and more acute as a result. We’ve seen hackers rise to the challenges presented by the events of the last few months in unexpected ways, coming up with imaginative solutions and pressing the limits of what’s possible. What this community can do when it is faced with a real challenge is inspiring.

Now it’s time to take that momentum and apply it to some of the other problems the world is facing. For the 2020 Hackaday Prize, we’re asking you to throw your creativity at challenges in conservation, disaster response, assistive technology, and renewable resources. We’ve teamed up with leading non-profits in those areas, each of which has specific challenges they need you to address.

With $200,000 in prize money at stake, we’re sure you’re going to want to step up to the challenge. To help get you started, Majenta Strongheart, Head of Design and Partnerships at Supplyframe, will drop by the Hack Chat with all the details on the 2020 Hackaday Prize. Come prepared to pick her brain on what needs doing and how best to tackle the problems that the Prize is trying to address. And find out about all the extras, like the “Dream Team” microgrants, the wild card prize, and the community picks.

join-hack-chatOur Hack Chats are live community events in the Hackaday.io Hack Chat group messaging. This week we’ll be sitting down on Wednesday, May 27 at 12:00 PM Pacific time. If time zones have got you down, we have a handy time zone converter.

Click that speech bubble to the right, and you’ll be taken directly to the Hack Chat group on Hackaday.io. You don’t have to wait until Wednesday; join whenever you want and you can see what the community is talking about.

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Hackaday Links: May 24, 2020

We’re saddened to learn of the passing of Gershon Kingsley in December 2019 at the age of 97. The composer and electronic music pioneer was not exactly a household name, but the things he did with the Moog synthesizer, especially the surprise hit “Pop Corn”, which he wrote in 1969, are sure to be familiar. The song has been covered dozens of times, in the process of which the spelling of the name changed to “Popcorn.” We’re most familiar with the 1972 cover by Hot Butter, an earworm from our youth that doesn’t hide the Moog as deeply in the backing instruments as Kingsley did in the original. Or, perhaps you prefer the cover done by a robotic glockenspiel, because robotic glockenspiel.

A few months back, we covered the audacious plan to recover the radio gear from the Titanic. At the time, the potential salvors, Atlanta-based RMS Titanic, Inc., were seeking permission to cut into the submerged remains of the Titanic‘s Marconi room to remove as much of the wireless gear as possible. A federal judge granted permission for the salvage operation last Friday, giving the company the green light to prepare an expedition for this summer. The US government, through the National Oceanic and Atmospheric Administration and the National Park Service, argued strenuously to leave the wreck be and treat it as a tomb for the 1,527 victims. For our part, we had a great discussion about the merits in the comments section of the previous article. Now that it’s a done deal, we’d love to hear what you have to say about this again.

Although life appears to be slowly returning to what passes for normal, that doesn’t mean you might not still have some cycles to spare, especially when the time spent can bolster your skillset. And so if you’re looking to adding FPGAs to your resume, check out this remote lab on FPGA vision systems offered by Bonn-Rhein-Sieg University. The setup allows you to watch lectures, download code examples, and build them on your local computer, and then upload the resulting binaries to real hardware running on the lab’s servers in Germany. It sounds like a great way to get access to FPGA hardware that you’d otherwise have a hard time laying hands on. Or, you know, you could have just come to the 2019 Hackaday Superconference.

Speaking of skill-builders, oscilloscope owners who want to sharpen their skills could do worse than to listen to the advice of a real scope jockey like Allen Wolke. He recently posted a helpful video listing the five most common reasons for your scope giving “wrong” voltage readings. Spoiler alert: the instrument is probably doing exactly what you told it to do. As a scope newbie, we found the insights very helpful, and we can imagine even seasoned users could make simple mistakes like using the wrong probe attenuation or forgetting that scope response isn’t flat across its bandwidth.

Safety tip for the gearheads among us: your jack stands might be unsafe to use. Harbor Freight, the stalwart purveyor of cheap tools, has issued a recall of two different models of its jack stands. It seems that the pawls can kick out under the right conditions, sending the supported load crashing to the ground. This qualifies as a Very Bad Day for anyone unlucky enough to be working underneath when it happens. Defective jack stands can be returned to Harbor Freight for store credit, so check your garage and be safe out there in the shop.

And finally, because everyone loves a good flame war, Ars Technica has come up with a pronunciation guide for common tech terms. We have to admit that most of these are not surprising; few among the technology literate would mispronounce “Linux” or “sudo”. We will admit to a non-fanboy level of ignorance on whether the “X” in “iOS X” was a Roman numeral or not, but learning that the “iOS” part is correctly pronounced as three syllables, not two was a bit shocking. It’s all an exercise in pedantry that reminds us of a mildly heated discussion we had around the secret Hackaday writers’ bunker and whether “a LED” or “an LED” is the correct style. If the Internet was made for anything, it was stuff like this.

Start Your Engines!

Here we go again: The 2020 Hackaday Prize has just been announced! And as usual, we want to see you all using your powers for good, to help make the world a better place. The twist this year is that four nonprofits have been selected, and your job is to help them with their goals: developing solutions to aid ocean conservation, creating or redesigning open-source assistive tools for people with cerebral palsy, designing modular housing for communities in need, and engineering open-source medical and technical tools that can be easily built in the field.

How often have you wanted to help, but been held back by lacking the background knowledge of which problems to tackle, or where to start? That’s the point of teaming up with non-profits that already have a very tangible need right now.

Oh, and did we mention the prize money? Not only can you do good, but you’ll also do well! The Best All Around Solution gets $50,000, there are four $10,000 prizes, one for each non-profit, $3,000 honorable mentions, a $5,000 wildcard, twenty $500community-chosen prizes, and then the twelve two-month Dream Team grants.

Pshwew! There’s something for everyone, and that’s made possible by our sponsors:Supplyframe, Digi-Key, Microchip, and ARM.

We’ve got four good ways for you to do good. Get out there and get hacking!

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Hackaday Podcast 068: Picky Feeders, Slaggy Tables, Wheelie Droids, And Janky Batteries

Hackaday editors Elliot Williams and Mike Szczys ride the rails of hackerdom, exploring the sweetest hacks of the past week. There’s a dead simple component feeder for a pick and place (or any bench that hand-stuffs SMD), batteries for any accomplished mixologist, and a droid build that’s every bit as cool as its Star Wars origins. Plus we gab about obsolescence in the auto industry, fawn over a frugal microcontroller, and ogle some old iron.

Take a look at the links below if you want to follow along, and as always, tell us what you think about this episode in the comments!

Direct download (60 MB or so.)

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This Week In Security: DNS DDOS, Revenge Of The 15 Year Old Bug, And More

Another DDOS amplification technique has just recently been disclosed, NXNSAttack (technical paper here) that could be used against DNS servers.

We’ve covered amplification attacks before. The short explanation is that some UDP services, like DNS, can be abused to get more mileage out of a DDoS attack. The attacking machined send messages like this: “Hello Google DNS, This is the Hackaday server. Can you send me a really big DNS response packet?” If the DNS response is bigger than the request, then the overall attack is bigger as a result. The measure of effectiveness is the amplification factor. For every byte of DDoS sent by attacking machines, how much many bytes are actually sent to the victim machine? Mirai, for example, had an amplification factor of something around 2.6.

NXNSAttack has a theoretical per-byte amplification factor of 163. That’s not a missed decimal point, this has the potential to be quite the nasty problem. Continue reading “This Week In Security: DNS DDOS, Revenge Of The 15 Year Old Bug, And More”