Treatment Triggers Teeth To Thrive

April 13, 2021 by Kristina Panos 38 Comments

We humans like to think we’re pretty advanced, but we can’t regrow missing teeth in adulthood like sharks, alligators, and crocodiles. Once those pearly whites are gone, they’re gone for good, and we don’t even have a way to regenerate the protective enamel. However, this may not always be the case, because scientists at Kyoto University and University of Fukui in Japan have discovered a monoclonal antibody treatment that triggers tooth regeneration in laboratory mice.

Image by Katsu Takahashi/Kyoto University via Medical Express

Monoclonal antibodies are lab-fabbed molecules that act as substitute antibodies to enhance the body’s natural defenses against diseases like cancer and arthritis. These antibodies are also used to develop vaccines and treat COVID-19. In the case of cancer, monoclonal antibodies bind to antigens on cancer cells, effectively flagging them for removal, but they also do much more, such as deliver chemo and radioimmunotherapies.

By blocking the gene USAG-1, the scientists saw an increase in Bone Morphogenic Protein (BMP), which is a molecule that dictates the number of teeth a given creature will have in the first place. Because of this increase in BMP, the mice were able to regrow teeth. This proposition was a challenging one — BMP affects other aspects of development, and the early attempts did more harm than good by causing birth defects. The good news is that the treatment also worked in ferrets, whose teeth are much closer to human dentition than mice. Before moving on to human trials, the scientists will test it out on pigs and dogs. If you were given a second shot at a set of teeth, would you treat them better than the first, or even worse because you can just grow new ones again?

Speaking of pigs, it seems that pig-to-human organ transplants are on track for 2021.

Zinc Fever: A Look At The Risks Of Working With Hot Metal

April 12, 2021 by Dan Maloney 69 Comments

For as raucous as things can get in the comments section of Hackaday articles, we really love the give and take that happens there. Our readers have an astonishing breadth of backgrounds and experiences, and the fact that everyone so readily shares those experiences and the strongly held opinions that they engender is what makes this community so strong and so useful.

But with so many opinions and experiences being shared, it’s sometimes hard to cut through to the essential truth of an issue. This is particularly true where health and safety are at issue, a topic where it’s easy to get bogged down by an accumulation of anecdotes that mask the underlying biology. Case in point: I recently covered a shop-built tool cabinet build and made an off-hand remark about the inadvisability of welding zinc-plated drawer slides, having heard about the dangers of inhaling zinc fumes once upon a time. That led to a discussion in the comments section on both sides of the issue that left the risks of zinc-fume inhalation somewhat unclear.

To correct this, I decided to take a close look at the risks involved with welding and working zinc. As a welding wannabe, I’m keenly interested in anything that helps me not die in the shop, and as a biology geek, I’m also fascinated by the molecular mechanisms of diseases. I’ll explore both of these topics as we look at the dreaded “zinc fever” and how to avoid it.

Continue reading “Zinc Fever: A Look At The Risks Of Working With Hot Metal” →

A Simple But Effective High-Flow Oxygen Concentrator From Hardware Store Parts

March 24, 2021 by Dan Maloney 76 Comments

To say that a lot has happened in the year since the COVID-19 pandemic started is an understatement of epic proportions, so much so that it may be hard to remember how the hardware hacking community responded during those early days, with mass-produced PPE, homebrew ventilators and the like. But we don’t recall seeing too many attempts to build something like this DIY oxygen concentrator during that initial build-out phase.

Given the simplicity and efficacy of the design, dubbed OxiKit, it seems strange that we didn’t see more of these devices. OxiKit uses zeolite, a porous mineral that can be used as a molecular sieve. The tiny beads are packed into columns made from hardware store PVC pipes and fittings and connected to an oil-less air compressor through some solenoid-controlled pneumatic valves. After being cooled in a coil of copper pipe, the compressed air is forced through one zeolite column, which preferentially retains the nitrogen while letting the oxygen pass through. The oxygen stream is split, with part going into a buffer tank and part going into the outlet of the second zeolite column, where it forces the adsorbed nitrogen to be released. An Arduino controls the valves that alternate the gas flow back and forth, resulting in 15 liters per minute of 96% pure oxygen.

OxiKit isn’t optimized as a commercial oxygen concentrator is, so it’s not particularly quiet. But it’s a heck of a lot cheaper than a commercial unit, and an easy build for most hackers. OxiKit’s designs are all open source, but they do sell kits and some of the harder-to-source parts and supplies, like the zeolite. We’d be tempted to build something like this just because the technology is so neat; having a source of high-flow oxygen available isn’t a bad idea, either.

Hey Google, Is My Heart Still Beating?

March 23, 2021 by Tom Nardi 18 Comments

University of Washington researchers studying the potential medical use of smart speakers such as Amazon’s Echo and Google’s Nest have recently released a paper detailing their experiments with non-contact acoustic heartbeat detection. Thanks to their sensitive microphone arrays, normally used to help localize voice commands from the user, the team proposes these affordable and increasingly popular smart home gadgets could lead a double life as unobtrusive life sign monitors. The paper goes so far as to say that even with multiple people in the room, their technique can be used to monitor the heart and respiratory rate of a specific target individual.

Those are some bold claims, but they aren’t without precedent. Previous studies performed at UW in 2019 demonstrated how smart speaker technology could be used to detect cardiac arrest and monitor infant breathing. This latest paper could be seen as the culmination of those earlier experiments: a single piece of software that could not just monitor the vitals of nearby patients, but actually detect a medical emergency. The lifesaving potential of such a program, especially for the very young and elderly, would be incredible.

So when will you be able to install a heart monitor skill on the cheap Echo Dot you picked up on Prime Day? Well, as is often the case with this kind of research, putting the technique to work in the real-world isn’t nearly as easy as in the laboratory. While the concept is promising and is more than worthy of further research, it may be some time before our lowly smart speakers are capable of Star Trek style life-sign detection.

Continue reading “Hey Google, Is My Heart Still Beating?” →

How To Monitor Blood Pressure Without Raising It

February 27, 2021 by Kristina Panos 16 Comments

Does anyone actually enjoy the sensation of being squeezed by a blood pressure cuff? Well, as Mom used to say, it takes all kinds. For those who find the feeling nearly faint-inducing, take heart: researchers at UC San Diego have created a non-invasive medical wearable with a suite of sensors that can measure blood pressure and monitor multiple biochemicals at the same time.

The device is a small, flexible patch that adheres to the skin. So how does it manage to measure blood pressure without causing discomfort? The blood pressure sensor consists of eight customized piezoelectric transducers that bounce ultrasonic waves off the near and far walls of the artery. Then the sensor calculates the time of flight of the resulting echoes to gauge arterial dilation and contraction, which amounts to a blood pressure reading.

This patch also has a chemical sensor that uses a drug called pilocarpine to induce the skin to sweat, and then measures the levels of lactate, caffeine, and alcohol found within. To monitor glucose levels, a mild current stimulates the release of interstitial fluid — the stuff surrounding our cells that’s rife with glucose, salt, fatty acids, and a few minerals. This is how continuous glucose monitoring for diabetes patients works today. You can check out the team’s research paper for more details on the patch and its sensors.

In the future, the engineers are hoping to add even more sensors and develop a wireless version that doesn’t require external power. Either way, it looks much more comfortable and convenient than current methods.

A Brief History Of Viruses

February 22, 2021 by Will Sweatman 23 Comments

It was around the year 1590 when mankind figured out how to use optical lenses to bring into sight things smaller than the natural eye can observe. With the invention of the microscope, a new and unexplored world was discovered. It will likely be of great surprise to the reader that scientists of the time did not believe that within this new microscopic realm lay the source of sickness and disease. Most would still hold on to a belief of what was known as Miasma theory, which dates back to the Roman Empire. This theory states that the source of disease was contaminated air through decomposing organic materials. It wouldn’t be until the 1850’s that a man by the name of Louis Pasteur, from whom we get “pasteurization”, would promote Germ Theory into the spotlight of the sciences.

Louis Pasteur experimenting in his lab. — Louis Pasteur. Source

Pasteur, considered by many as the father of microbiology, would go on to assist fellow biologist Charles Chameberland in the invention of the aptly named Pasteur Chamberland filter — a porcelain filter with a pore size between 100 and 1000 nanometers. This was small enough to filter out the microscopic bacteria and cells known at that time from a liquid suspension, leaving behind a supply of uncontaminated water. But like so many other early scientific instrumentation inventions it would lead to the discovery of something unexpected. In this case, a world far smaller than 100 nanometers… and add yet another dimension to the ever-shrinking world of the microscopic.

This is when we began to learn about viruses.

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Listening In On Muscles With The BioAmp EMG Pill

February 15, 2021 by Maya Posch 49 Comments

Ever felt like what your MCU of choice misses is a way to read the electrical signals from your muscles? In that case [Deepak Khatri] over at Upside Down Labs has got your back with the BioAmp EMG Pill. Described as an affordable, open source electromyography (EMG) module, based around a TL074 quad low-noise JFET-input opamp. At just over 32×10 millimeters, it’s pretty compact as well.

The onboard opamp ensures that the weak electrical signals captured from the muscles when they move are amplified sufficiently that the ADC of any microcontroller or similar can capture the signal for further processing. Some knowledge of how to set up an EMG is required to use the module, of course, and the TL074 opamp prefers an input voltage between 7-30 V. Even so, it has all the basics onboard, and the KiCad project is freely available via the above linked GitHub project.

In addition, [Deepak] also tweeted about working on an affordable, open source active prosthetics controller (and human augmentation device), which has us very much interested in what other projects may come out of Upside Down Labs before long. After, all we’re no strangers to hacking with biosignals.