Seeking Enlightenment: The Quest To Restore Vision In Humans

December 29, 2020 by Maya Posch 16 Comments

Visual impairment has been a major issue for humankind for its entire history, but has become more pressing with society’s evolution into a world which revolves around visual acuity. Whether it’s about navigating a busy city or interacting with the countless screens that fill modern life, coping with reduced or no vision is a challenge. For countless individuals, the use of braille and accessibility technology such as screen readers is essential to interact with the world around them.

For refractive visual impairment we currently have a range of solutions, from glasses and contact lenses to more permanent options like LASIK and similar which seek to fix the refractive problem by burning away part of the cornea. When the eye’s lens itself has been damaged (e.g. with cataracts), it can be replaced with an artificial lens.

But what if the retina or optic nerve has been damaged in some way? For individuals with such (nerve) damage there has for decades been the tempting and seemingly futuristic concept to restore vision, whether through biological or technological means. Quite recently, there have been a number of studies which explore both approaches, with promising results.

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Analyzing The “Source Code” Of The COVID-19 Vaccine

December 26, 2020 by Lewin Day 54 Comments

Computer programs are written in code, which comes in many forms. At the lowest level, there’s machine code and assembly, while higher-level languages like C and Python aim to be more human-readable. However, the natural world has source code too, in the form of DNA and RNA strings that contain the code for the building blocks of life. [Bert] decided to take a look at the mRNA source code of Tozinameran, the COVID-19 vaccine developed by BioNTech and Pfizer.

The analysis is simple enough for the general reader, while nonetheless explaining some highly complex concepts at the cutting edge of biology. From codon substitutions for efficiency and the Ψ-base substitution to avoid the vaccine being destroyed by the immune system, to the complex initialisation string required at the start of the RNA sequence, [Bert] clearly explains the clever coding hacks that made the vaccine possible. Particularly interesting to note is the Prolase substitution, a technique developed in 2017. This allows the production of coronavirus spike proteins in isolation of the whole virus, in order to safely prime the immune system.

It’s a great primer and we can imagine it might inspire some to delve further into the rich world of genetics and biology. We’ve featured other cutting edge stories on COVID-19 too; [Dan Maloney] took a look at how CRISPR techniques are helping with the testing effort. If there’s one thing the 2020 pandemic has shown, it’s humanity’s ability to rapidly develop new technology in the face of a crisis.

Webcam Heart Rate Monitor Brings Photoplethysmography To Your PC

December 25, 2020 by Adam Zeloof 31 Comments

It seems like within the last ten years, every other gadget to be released has some sort of heart rate monitoring capability. Most modern smartwatches can report your BPMs, and we’ve even seen some headphones with the same ability hitting the market. Most of these devices use an optical measurement method in which skin is illuminated (usually by an LED) and a sensor records changes in skin color and light absorption. This method is called Photoplethysmography (PPG), and has even been implemented (in a simple form) in smartphone apps in which the data is generated by video of your finger covering the phone camera.

The basic theory of operation here has its roots in an experiment you probably undertook as a child. Did you ever hold a flashlight up to your hand to see the light, filtered red by your blood, shine through? That’s exactly what’s happening here. One key detail that is hard to perceive when a flashlight is illuminating your entire hand, however, is that deoxygenated blood is darker in color than oxygenated blood. By observing the frequency of the light-dark color change, we can back out the heart rate.

This is exactly how [Andy Kong] approached two methods of measuring heart rate from a webcam.

Method 1: The Cover-Up

The first detection scheme [Andy] tried is what he refers to as the “phone flashlight trick”. Essentially, you cover the webcam lens entirely with your finger. Ambient light shines through your skin and produces a video stream that looks like a dark red rectangle. Though it may be imperceptible to us, the color changes ever-so-slightly as your heart beats. An FFT of the raw data gives us a heart rate that’s surprisingly accurate. [Andy] even has a live demo up that you can try for yourself (just remember to clean the smudges off your webcam afterwards).

Method 2: Remote Sensing

Now things are getting a bit more advanced. What if you don’t want to clean your webcam after each time you measure your heart rate? Well thankfully there’s a remote sensing option as well.

For this method, [Andy] is actually using OpenCV to measure the cyclical swelling and shrinking of blood vessels in your skin by measuring the color change in your face. It’s absolutely mind-blowing that this works, considering the resolution of a standard webcam. He found the most success by focusing on fleshy patches of skin right below the eyes, though he says others recommend taking a look at the forehead.

Every now and then we see something that works even though it really seems like it shouldn’t. How is a webcam sensitive enough to measure these minute changes in facial color? Why isn’t the signal uselessly noisy? This project is in good company with other neat heart rate measurement tricks we’ve seen. It’s amazing that this works at all, and even more incredible that it works so well.

TI EZ430-Chronos Turned Medical Alert Wearable

December 22, 2020 by Tom Nardi 29 Comments

Long before the current smartwatch craze, Texas Instruments released the eZ430-Chronos. Even by 2010s standards, it was pretty clunky. Its simple LCD display and handful of buttons also limited what kind of “smart” tasks it could realistically perform. But it did have one thing going for it: its SDK allowed users to create a custom firmware tailored to their exact specifications.

It’s been nearly a decade since we’ve seen anyone dust off the eZ430-Chronos, but that didn’t stop [ogdento] from turning one into a custom alert device for a sick family member. A simple two-button procedure on the watch will fire off emails and text messages to a pre-defined list of contacts, all without involving a third party or have to pay for a service contract. Perhaps most importantly, the relatively energy efficient eZ430 doesn’t need to be recharged weekly or even daily as would be the case for a modern smartwatch.

To make the device as simple as possible, [ogdento] went through the source code for the stock firmware and commented out every function beyond the ability to show the time. With the watch’s menu stripped down to the minimum, a new alert function was introduced that can send out a message using the device’s 915 MHz CC1101 radio.

Messages and recipients can easily be modified.

The display even shows “HELP” next to the appropriate button so there’s no confusion. A second button press is required to send the alert, and there’s even a provision for canceling it should the button be pressed accidentally.

On the receiving side, [ogdento] is using a Raspberry Pi with its own CC1101 radio plugged into the USB port. When the Python scripts running on the Pi picks up the transmission coming from the eZ430 it starts working through a list of recipients to send messages to. A quick look at the source code shows it would be easy to provide your own contact list should you want to put together your own version of this system.

We’ve seen custom alert hardware before, but like [ogdento] points out, using the eZ430-Chronos provides a considerable advantage in that its a turn-key platform. It’s comfortable to wear, reliable, and fairly rugged. While some would argue against trusting independently developed code for such a vital task, at least the hardware is a solved problem.

Sit Up Straight!: Open Source Bluetooth Posture Sensing

December 16, 2020 by Danie Conradie 4 Comments

As more and more people spend their working hours behind a computer, bad posture and the accompanying back pain and back problems become a growing epidemic. To combat this in his own daily life, [ImageryEel] made PosturePack, a wearable Bluetooth-enabled posture sensor.

The PosturePack is designed to fit into a small pocket sewn into the pack of an undershirt, between the shoulder blades. It consists of a custom PCB with an ATmega32U4, BNO055 IMU, Bluetooth module, small LiPo and power circuitry. Based on the orientation data from the IMU, a notification is sent over Bluetooth to a smartphone whenever the user hunches forward.

[ImageryEel] says although the mobile notifications worked, haptic feedback integrated into the unit would be a better option. This could also be used to remind the user to stand up and take a break now and then, and provide an alternative to a smartwatch for activity monitoring without sending every movement to someone else’s servers. Software will always be the hardest part for projects like these, especially as the device become “smarter”. Learning to recognize activity and postures is actually a good place for tiny machine learning models.

Compared The posture sensors we covered before had to be installed and set up at a specific workstation, like an ultrasound-based version attached to a chair, and a webcam-based version.

Hybrid Respirator Uses Repurposed Filters

December 5, 2020 by Lewin Day 15 Comments

With the coronavirus raging worldwide, 2020 has seen major shortages of personal protective equipment impact healthcare workers and individuals alike. This has led many to improvise their own solutions. One of the more complete offerings we’ve seen is this hybrid respirator build from [Ben Howard].

[Ben’s] build goes above and beyond the usual craft project masks. It uses a laser-cut chipboard frame to fit three HEPA filters, originally designed for the Roomba robotic vacuum cleaner. Two are used for exhalation, while one is used for inhalation. A small blower fan is installed with the intake filter, to provide mild positive pressure when breathing in. The assembly is wrapped up in fabric, using layers of spandex, fleece, and ripstop nylon to provide the best possible seal against the wearer’s face.

It’s a build that should appeal to those who want to breathe cleaner air and also protect others from exhaled particles that can spread respiratory viruses. We’ve seen all kind of masks hit the scene this year; the graphene-impregnated variety is one of the more interesting designs. Still, one can hope that future years lead to less reliance on such measures!

The Special Fridges Behind The COVID-19 Vaccine, Why It’s Surprisingly Difficult To Be That Cool

November 17, 2020 by Jenny List 162 Comments

One of the big stories last week was the announcement of results from clinical trials that suggest a new COVID-19 vaccine developed through the joint effort of the American and German companies Pfizer and BioNTech is strongly effective in providing immunity from the virus. In the midst of what is for many countries the second spike of the global pandemic this news has been received with elation as well as becoming the subject of much political manoeuvring.

While we currently have two vaccine candidates with very positive testing results, one of the most interesting things for us is the need to keep doses of the Pfizer/BioNTech vaccine extremely cold until they are administered. Let’s dig into details of the refrigeration problem at hand.

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