Brain Implant Uses Graphene Instead Of Metal Probes

July 23, 2024 by Maya Posch 7 Comments

Implantable electrodes for the (human) brain have been around for a many decades in the form of Utah arrays and kin, but these tend to be made out of metal, which can cause issues when stimulating the surrounding neurons with an induced current. This is due to faradaic processes between the metal probe and an electrolyte (i.e. the cerebrospinal fluid). Over time this can result in insulating deposits forming on the probe’s surface, reducing their effectiveness.

Graphene-based, high-resolution cortical brain interface (Credit: Inbrain Neuroelectronics)

Now a company called InBrain claims to have cracked making electrodes out of graphene, following a series of tests on non-human test subjects. Unlike metal probes, these carbon-based probes should be significantly more biocompatible even when used for brain stimulation as with the target goal of treating the symptoms associated with Alzheimer’s.

During the upcoming first phase human subjects would have these implants installed where they would monitor brain activity in Alzheimer’s patients, to gauge how well their medication is helping with the symptoms like tremors. Later these devices would provide deep-brain stimulation, purportedly more efficiently than similar therapies in use today. The FDA was impressed enough at least to give it the ‘breakthrough device’ designation, though it is hard to wade through the marketing hype to get a clear picture of the technology in question.

In their most recently published paper (preprint) in Nature Nanotechnology, [Calia] and colleagues describe flexible graphene depth neural probes (gDNP) which appear to be what is being talked about. These gDNP are used in the experiment to simultaneously record infraslow (<0.1 Hz) and higher frequencies, a feat which metal microelectrodes are claimed to struggle with.

Although few details are available right now, we welcome any brain microelectrode array improvements, as they are incredibly important for many types of medical therapies and research.

Small Mammals Appear To Have A Secret Infrared Sense

July 22, 2024 by Lewin Day 21 Comments

If you’ve ever watched Predator, you’ve noted the tactical advantage granted to the alien warrior by its heat vision. Indeed, even with otherwise solid camoflauge, Dutch and his squad ended up very much the hunted.

And yet, back in reality, it seems the prey might be the one with the ability to sense in the infrared spectrum. Research has now revealed this unique ability may all be down to the hairs on the back of some of the smallest mammals.

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A cartoon of the Sun above a windmill and a solar panel with a lightning bolt going to a big grey gear with "AAAp" written on it. A small "e-" on a circle is next to it, indicating electricity transfer. Further to the right is an ADP molecule connected to a curved arrow going through the AAAp gear to turn into ATP. Three cartoon shapes, presumably illustrating biological processes are on the right with arrows pointing from the ATP.

Powering Biology With Batteries

July 21, 2024 by Navarre Bartz 18 Comments

We’ve all been there — you forgot your lunch, but there are AC outlets galore. Wouldn’t it be so much simpler if you could just plug in like your phone? Don’t try it yet, but biologists have taken us one step further to being able to fuel ourselves on those sweet, sweet electrons.

Using an “electrobiological module” of 3-4 enzymes, the amusingly named AAA (acid/aldehyde ATP) cycle regenerates ATP in biological systems directly from electricity. The process takes place at -0.6 V vs a standard hydrogen electrode (SHE), and is compatible with biological transcription/translation processes like “RNA and protein synthesis from DNA.”

The process isn’t dependent on any membranes to foul or more complicated sets of enzymes making it ideal for in vitro synthetic biology since you don’t have to worry about keeping as many components in an ideal environment. We’re particularly interested in how this might apply to DNA computing which we keep being promised will someday be the best thing since the transistor.

Maybe in the future we’ll all jack in instead of eating our daily food pill? If this all seems like something you’ve heard of before, but in reverse, maybe you’re thinking of microbial fuel cells.

Welding Wood Is As Simple As Rubbing Two Sticks Together

July 21, 2024 by Dan Maloney 12 Comments

Can you weld wood? It seems like a silly question — if you throw a couple of pieces of oak on the welding table and whip out the TIG torch, you know nothing is going to happen. But as [Action Lab] shows us in the video below, welding wood is technically possible, if not very practical.

Since experiments like this sometimes try to stretch things a bit, it probably pays to define welding as a process that melts two materials at their interface and fuses them together as the molten material solidifies. That would seem to pose a problem for wood, which just burns when heated. But as [Action Lab] points out, it’s the volatile gases released from wood as it is heated that actually burn, and the natural polymers that are decomposed by the heat to release these gases have a glass transition temperature just like any other polymer. You just have to heat wood enough to reach that temperature without actually bursting the wood into flames.

His answer is one of the oldest technologies we have: rubbing two sticks together. By chucking a hardwood peg into a hand drill and spinning it into a slightly undersized hole in a stick of oak, he created enough heat and pressure to partially melt the polymers at the interface. When allowed to cool, the polymers fuse together, and voila! Welded wood. Cutting his welded wood along the joint reveals a thin layer of material that obviously underwent a phase change, so he dug into this phenomenon a bit and discovered research into melting and welding wood, which concludes that the melted material is primarily lignin, a phenolic biopolymer found in the cell walls of wood.

[Action Lab] follows up with an experiment where he heats bent wood in a vacuum chamber with a laser to lock the bend in place. The experiment was somewhat less convincing but got us thinking about other ways to exclude oxygen from the “weld pool,” such as flooding the area with argon. That’s exactly what’s done in TIG welding, after all. Continue reading “Welding Wood Is As Simple As Rubbing Two Sticks Together” →

Sketch of the UED setup at EPFL, 1) Electron gun, 2) High-Voltage connector, 3) Photo-cathode, 4) Anode, 5) Collimating solenoid, 6) Steering plates, 7) Focusing solenoid, 8) RF cavity, 9) Sample holder, 10) Cryostat, 11) Electron detector, 12) Turbo pump, 13) Ion gauge. Credit: Proceedings of the National Academy of Sciences (2024). DOI: 10.1073/pnas.2316438121

Using Femtosecond Laser Pulses To Induce Metastable Hidden States In Magnetite

July 20, 2024 by Maya Posch No comments

Hidden states are a fascinating aspect of matter, as these can not normally be reached via natural processes (i.e. non-ergodic), but we can establish them using laser photoexcitation. Although these hidden states are generally very unstable and will often decay within a nanosecond, there is evidence for more persistent states in e.g. vanadates. As for practical uses of these states, electronics and related fields are often mentioned. This is also the focus in the press release by the Ecole Polytechnique Federale de Lausanne (EPFL) when reporting on establishing hidden states in magnetite (Fe₃O₄), with the study published in PNAS (Arxiv preprint link).

[B. Truc] and colleagues used two laser frequencies to either make the magnetite more conductive (800 nm) or a better insulator (400 nm). The transition takes on the order of 50 picoseconds, allowing for fairly rapid switching between these metastable states. Naturally, turning this into practical applications will require a lot more work, especially considering the need for femtosecond pulsed lasers to control the process, which makes it significantly more cumbersome than semiconductor technology. Its main use at this point in time will remain a fascinating demonstration of these hidden states of matter.

Sealed Packs Of Pokémon Cards Give Up Their Secrets Without Opening Them

July 20, 2024 by Donald Papp 32 Comments

[Ahron Wayne] succeeded in something he’s been trying to accomplish for some time: figuring out what’s inside a sealed Pokémon card packet without opening it. There’s a catch, however. It took buying an X-ray CT scanner off eBay, refurbishing and calibrating it, then putting a load of work into testing and scanning techniques. Then finally combining the data with machine learning in order to make useful decisions. It’s a load of work but [Ahron] succeeded by developing some genuinely novel techniques.

While using an X-ray machine to peek inside a sealed package seems conceptually straightforward, there are in fact all kinds of challenges in actually pulling it off. There’s loads of noise. So much that the resulting images give a human eyeball very little to work with. Luckily, there are also some things that make the job a little easier.

For example, it’s not actually necessary to image an entire card in order to positively identify it. Teasing out the individual features such as a fist, a tentacle, or a symbol are all useful to eliminate possibilities. Interestingly, as a side effect the system can easily spot counterfeit cards; the scans show up completely different.

When we first covered [Ahron]’s fascinating journey of bringing CT scanners back to life, he was able to scan cards but made it clear he wasn’t able to scan sealed packages. We’re delighted that he ultimately succeeded, and also documented the process. Check it out in the video below.

Continue reading “Sealed Packs Of Pokémon Cards Give Up Their Secrets Without Opening Them” →

The Continuing Venusian Mystery Of Phosphine And Ammonia

July 19, 2024 by Maya Posch 18 Comments

The planet Venus is in so many ways an enigma. It’s a sister planet to Earth and also within relatively easy reach of our instruments and probes, yet we nevertheless know precious little about what is going on its surface or even inside its dense atmosphere. Much of this is of course due to planets like Mars getting all the orbiting probes and rovers scurrying around on its barren, radiation-blasted surface, but we had atmospheric probes descend through Venus’ atmosphere, so far to little avail. Back in 2020 speculation arose of phosphine being detected in Venus’ atmosphere, which caused both excitement and a lot of skepticism. Regardless, at the recent National Astronomy Meeting (NAM 2024) the current state of Venusian knowledge was discussed, which even got The Guardian to report on it.

In addition to phosphine, there’s speculation of ammonia also being detectable from Earth, both of which might be indicative of organic processes and thus potentially life. Related research has indicated that common amino acids essential to life on Earth would be stable even in sulfuric droplets like in Venus’ atmosphere. After criticism to the original 2020 phosphine article, [Jane S. Greaves] et al. repeated their observations based on feedback, although it’s clear that the observation of phosphine gas on Venus is not a simple binary question.

The same is true of ammonia, which if present in Venusian clouds would be a massive discovery, which according to research by [William Bains] and colleagues in PNAS could explain many curious observations in Venus’ atmosphere. With so much uncertainty with remote observations, it’s clear that the only way that we are going to answer these questions is with future Venus missions, which sadly remain rather sparse.

If there’s indeed life on Venus, it’ll have a while longer to evolve before we can go and check it out.