diabetes

29 Articles

Implant Fights Diabetes By Making Insulin And Oxygen

October 10, 2023 by 13 Comments

Type 1 diabetes remains a problem despite having an apparently simple solution: since T1D patients have lost the cells that produce insulin, it should be possible to transplant those cells into their bodies and restore normal function. Unfortunately, it’s not actually that simple, and it’s all thanks to the immune system, which would attack and destroy transplanted pancreas cells, whether from a donor or grown from the patient’s own stem cells.

That may be changing, though, at least if this implantable insulin-producing bioreactor proves successful.  The device comes from MIT’s Department of Chemical Engineering, and like earlier implants, it relies on encapsulating islet cells, which are the insulin-producing cells within the pancreas, inside a semipermeable membrane. This allows the insulin they produce to diffuse out into the blood, and for glucose, which controls insulin production in islet cells, to diffuse in. The problem with this arrangement is that the resource-intensive islet cells are starved of oxygen inside their capsule, which is obviously a problem for the viability of the implant.

The solution: electrolysis. The O2-Macrodevice, as the implant is called, uses a tiny power-harvesting circuit to generate oxygen for the islet cells directly from the patient’s own interstitial water. The circuit applies a current across a proton-exchange membrane, which breaks water molecules into molecular oxygen for the islet cells. The hydrogen is said to diffuse harmlessly away; it seems like that might cause an acid-base imbalance locally, but there are plenty of metabolic pathways to take care of that sort of thing.

The implant looks promising; it kept the blood glucose levels of diabetic mice under control, while mice who received an implant with the oxygen-generating cell disabled started getting hyperglycemic after two weeks. What’s really intriguing is that the study authors seem to be thinking ahead to commercial production, since they show various methods for mass production of the cell chamber from standard 150-mm silicon wafers using photolithography.

Type 1 diabetics have been down the “artificial pancreas” road before, so a wait-and-see approach is clearly wise here. But it looks like treating diabetes less like a medical problem and more like an engineering problem might just pay dividends.

The New-Phone Blues: A Reminder That Hackers Shouldn’t Settle

March 22, 2022 by 67 Comments

For all the convenience and indispensability of having access to the sum total of human knowledge in the palm of your hand, the actual process of acquiring and configuring a smartphone can be an incredibly frustrating experience. Standing in those endless queues at the cell phone store, jumping through the administrative hoops, and staring in sticker shock at a device that’s likely to end its life dunked in a toilet all contribute to the frustration.

But for my money, the real trouble starts once you get past all that stuff and start trying to set up the new phone just right. Sure, most phone manufacturers make it fairly easy to clone your old phone onto the new one, but there are always hiccups. And for something that gets as tightly integrated into the workflows of your daily life as cell phones do, that can be a real bummer. Especially when you find out that your shiny new phone can’t do something you absolutely depend on.

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Tech In Plain Sight: Glucose Meters

October 20, 2021 by 27 Comments

If you or someone you know is diabetic, it is a good bet that a glucose meter is a regular fixture in your life. They are cheap and plentiful, but they are actually reasonably high tech — well, at least parts of them are.

The meters themselves don’t seem like much, but that’s misleading. A battery, a few parts, a display, and enough of a controller to do things like remember readings appears to cover it all. You wouldn’t be surprised, of course, that you can get the whole affair “on a chip.” But it turns out, the real magic is in the test strip and getting a good reading from a strip requires more metrology than you would think. A common meter requires a precise current measurement down to 10nA. The reading has to be adjusted for temperature, too. The device is surprisingly complex for something that looks like a near-disposable piece of consumer gear.

Of course, there are announcements all the time about new technology that won’t require a needle stick. So far, none of those have really caught on for one reason or another, but that, of course, could change. GlucoWatch G2, for example, was a watch that could read blood glucose, but — apparently — was unable to cope with perspiration.

Even the meters that continuously monitor still work in more or less the same way as the cheap meters. As Hackaday’s Dan Maloney detailed a few years back, continuous glucose monitors leave a tiny sensor under your skin and measure fluid in your body, not necessarily blood. But the way the sensor works is usually the same.

For the purposes of this article, I’m only going to talk about the traditional meter: you insert a test strip, prick your finger, and let the test strip soak up a little bit of blood.

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Open-Source Insulin: Biohackers Aiming For Distributed Production

August 23, 2021 by 74 Comments

When you’ve got a diabetic in your life, there are few moments in any day that are free from thoughts about insulin. Insulin is literally the first coherent thought I have every morning, when I check my daughter’s blood glucose level while she’s still asleep, and the last thought as I turn out the lights, making sure she has enough in her insulin pump to get through the night. And in between, with the constant need to calculate dosing, adjust levels, add corrections for an unexpected snack, or just looking in the fridge and counting up the number of backup vials we have on hand, insulin is a frequent if often unwanted intruder on my thoughts.

And now, as my daughter gets older and seeks like any teenager to become more independent, new thoughts about insulin have started to crop up. Insulin is expensive, and while we have excellent insurance, that can always change in a heartbeat. But even if it does, the insulin must flow — she has no choice in the matter. And so I thought it would be instructional to take a look at how insulin is made on a commercial scale, in the context of a growing movement of biohackers who are looking to build a more distributed system of insulin production. Their goal is to make insulin affordable, and with a vested interest, I want to know if they’ve got any chance of making that goal a reality.

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How To Monitor Blood Pressure Without Raising It

February 27, 2021 by 16 Comments

Does anyone actually enjoy the sensation of being squeezed by a blood pressure cuff? Well, as Mom used to say, it takes all kinds. For those who find the feeling nearly faint-inducing, take heart: researchers at UC San Diego have created a non-invasive medical wearable with a suite of sensors that can measure blood pressure and monitor multiple biochemicals at the same time.

The device is a small, flexible patch that adheres to the skin. So how does it manage to measure blood pressure without causing discomfort? The blood pressure sensor consists of eight customized piezoelectric transducers that bounce ultrasonic waves off the near and far walls of the artery. Then the sensor calculates the time of flight of the resulting echoes to gauge arterial dilation and contraction, which amounts to a blood pressure reading.

This patch also has a chemical sensor that uses a drug called pilocarpine to induce the skin to sweat, and then measures the levels of lactate, caffeine, and alcohol found within. To monitor glucose levels, a mild current stimulates the release of interstitial fluid — the stuff surrounding our cells that’s rife with glucose, salt, fatty acids, and a few minerals. This is how continuous glucose monitoring for diabetes patients works today. You can check out the team’s research paper for more details on the patch and its sensors.

In the future, the engineers are hoping to add even more sensors and develop a wireless version that doesn’t require external power. Either way, it looks much more comfortable and convenient than current methods.

Electronic Treatment For Diabetes?

October 9, 2020 by 24 Comments

If you ask power companies and cell phone carriers how much electromagnetic radiation affects the human body, they’ll tell you it doesn’t at any normal levels. If you ask [Calvin Carter] and some other researchers at the University of Iowa, they will tell you that it might treat diabetes. In a recent paper in Cell Metabolism, they’ve reported that exposing patients to static magnetic and electric fields led to improved insulin sensitivity in diabetic mice.

Some of the medical jargon in a paper like this one can be hard to follow, but it seems they feed mice on a bad diet — like that which many of us may eat — and exposed them to magnetic and electrical fields much higher than that of the Earth’s normal fields. After 30 days there was a 33% improvement in fasting blood glucose levels and even more for some mice with a specific cause of diabetes.

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A Sweet Little Insulin Reminder Light

May 19, 2020 by 5 Comments

So much of what we do relies on a certain societal structure that has been absent for a few months now. When the days run together, it’s hard to remember to do the things that must happen daily. You think you did something, and maybe you’re right, but it’s quite possible you’re thinking of yesterday.

[Flameeyes] has diabetes and must use an insulin pen every morning without fail, no matter what’s happening outside his door. This was pretty much a non-issue in the before-time, but quickly became a serious problem as the routine-free weeks wore on. With no room for false positives, he needed a solution that doesn’t trigger until the deed is done.

Now when [Flameeyes] puts the pen away, he also triggers a Flic smart button mounted nearby. The Flic shares its status with a Feather M4 Express through a web app, and the Feather in turn changes the RGB LED inside of Pikachu’s base from red to yellow for the day. Pikachu sits in plain sight by the kettle, so there’s no guessing whether [Flameeyes] took his insulin.

Insulin is a critical commodity with a lot of DIY interest, which is probably starting to spike about now. Our own [Dan Maloney] wrote a great piece on the subject that brings up an insulin hack from around 80 years ago.