How Biohackers are Fighting a Two-front War on Antibiotic Resistance

We humans like to think of ourselves as the pinnacle of evolution on the planet, but that’s just a conceit. It takes humans roughly twenty years to reproduce, whereas some bacteria can make copies of themselves every 20 minutes. Countless generations of bacteria have honed and perfected their genomes into extremely evolved biological machines.

Most bacteria are harmless, and some are quite useful, even tasty – witness the lactofermented pickles and sauerkraut I made this summer. But some bacteria are pathogenic nightmares that have swarmed over the planet and caused untold misery and billions of deaths. For most of human history it has been so – the bugs were winning. Then a bright period dawned in the early 20th century – the Era of Antibiotics. At last we were delivered from the threat of pestilence, never more to suffer from plague and disease like our unfortunate ancestors. Infections were miraculously cured with a simple injection or pill, childhood diseases were no longer reaping their tragic harvest, and soldiers on the battlefield were surviving wounds that would have festered and led to a slow, painful death.

Now it seems like this bright spot of relief from bacterial disease might be drawing to an end. Resistant strains of bacteria are in the news these days, and the rise of superbugs seems inevitable. But is it? Have we run out of tools to fight back? Not quite yet as it turns out. But there’s a lot of work to do to make sure we win this battle.

Continue reading “How Biohackers are Fighting a Two-front War on Antibiotic Resistance”

Original hardware for fifteen consoles jammed into recently completed Project Unity


This boxy monstrosity is big for a reason. It lets you play games on the original hardware of fifteen different gaming consoles. That’s right, we said original hardware. One of the main goals of Project Unity was to keep the stock equipment by making any type of emulation — hardware or otherwise — taboo. The size of the case is a function of how much stuff is actually crammed in there. But the final shape was dictated by the available opening in [Bacteria’s] living room entertainment center.

The video after the break walks us through each aspect of the build. We’re floored by the quote of 3,500 hours of build time. But as you get a look at the wiring-hell of each different module it’s easy to understand why it didn’t just build itself. One power supply and one controller make for the least complicated user experience possible. We already looked at a giant switching mechanism that selects one console at a time and the singular controller unit. But [Bacteria] has a lot of other tricks up his sleeve which make this gold mine of a hacking reference piece.

Continue reading “Original hardware for fifteen consoles jammed into recently completed Project Unity”