Day: December 13, 2025

A biohacker with her lactose-rich slurry

Biohack Your Way To Lactose Tolerance (Through Suffering)

December 13, 2025 by 17 Comments

A significant fraction of people can’t handle lactose, like [HGModernism]. Rather than accept a cruel, ice cream free existence, she decided to do something you really shouldn’t try: biohacking her way to lactose tolerance.

The hack is very simple, and based on a peer reviewed study from the 1990s: consume lactose constantly, and suffer constantly, until… well, you can tolerate lactose. If you’re lactose intolerant, you’re probably horrified at the implications of the words “suffer constantly” in a way that those milk-digesting-weirdos could never understand. They probably think it is hyperbole; it is not. On the plus side, [HGModernism]’s symptoms began to decline after only one week.

The study dates back to the 1980s, and discusses a curious phenomenon where American powdered milk was cluelessly distributed during an African famine. Initially that did more harm than good, but after a few weeks mainlining the white stuff, the lactose-intolerant Africans stopped bellyaching about their bellyaches.

Humans all start out with a working lactase gene for the sake of breastfeeding, but in most it turns off naturally in childhood. It’s speculated that rather than some epigenetic change turning the gene for lactose tolerance back on — which probably is not possible outside actual genetic engineering — the gut biome of the affected individuals shifted to digest lactose painlessly on behalf of the human hosts. [HGModernism] found this worked but it took two weeks of chugging a slurry of powdered milk and electrolyte, formulated to avoid dehydration due to the obvious source of fluid loss. After the two weeks, lactose tolerance was achieved.

Should you try this? Almost certainly not. [HGModernism] doesn’t recommend it, and neither do we. Still, we respect the heck out any human willing to hack the way out of the limitations of their own genetics. Speaking of, at least one hacker did try genetically engineering themselves to skip the suffering involved in this process. Gene hacking isn’t just for ice-cream sundaes; when applied by real medical professionals, it can save lives.

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PJON, Open Single-Wire Bus Protocol, Goes Verilog

December 13, 2025 by 4 Comments

Did OneWire of DS18B20 sensor fame ever fascinate you in its single-data-line simplicity? If so, then you’ll like PJON (Padded Jittering Operative Network) – a single-wire-compatible protocol for up to 255 devices. One disadvantage is that you need to check up on the bus pretty often, trading hardware complexity for software complexity. Now, this is no longer something for the gate wielders of us to worry about – [Giovanni] tells us that there’s a hardware implementation of PJDL (Padded Jittering Data Link), a PJON-based bus.

This implementation is written in Verilog, and allows you to offload a lot of your low-level PJDL tasks, essentially, giving you a PJDL peripheral for all your inter-processor communication needs. Oh, and as [Giovanni] says, this module has recently been taped out as part of the CROC chip project, an educational SoC project. What’s not to love?

PJON is a fun protocol, soon to be a decade old. We’ve previously covered [Giovanni] use PJON to establish a data link through a pair of LEDs, and it’s nice to see this nifty small-footprint protocol gain that much more of a foothold, now, in our hardware-level projects.

We thank [Giovanni Blu Mitolo] for sharing this with us!