Genetically Modified Mosquitos: Biohacking For Disease Prevention

Many years ago, I took a summer trip to the Maryland shore with some friends. One of my buddies and I got bored with playing football on the beach, so we decided to take a hike on one of the many trails back into the wooded area behind the dunes. At the trailhead we noticed a prominent sign, warning about the presence of “very aggressive mosquitos” and not to enter without first applying ample insect repellent. We scoffed at the warning as only young idiots could and soldiered on, bare-legged and confident that we’d be fine.

About three minutes into our hike, a small group came pelting down the trail in a panic. “It’s true! Turn back!” they shouted as they flew past us. Undeterred, or at least unwilling to appear that way to each other, we pressed on, only to discover a few minutes later that we were making a substantial blood sacrifice to the next generation of mosquitos on Assateague Island. We couldn’t bear more than a few seconds before turning tail and running back to the beach and jumping into the ocean to get rid of the last few dozen bloodsuckers.

I learned a valuable lesson from that experience, as well as developing a deep and abiding hatred of mosquitos. It turns out I’m in good company — pretty much everyone hates mosquitos, which are not just a nuisance but can be downright dangerous to be around. But if tests with genetically engineered mosquitos currently underway in Florida turn out well, we may be able to finally turn the tide against mosquito-borne diseases, simply by killing all the females before they ever reach adulthood.

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Mice Develop Inside An Artificial Womb

Well, it looks like those fetus fields from The Matrix (1999) just became a little bit more plausible. Although people-growing is probably a long way off, mice can now mostly develop inside an artificial uterus (try private window if you hit a paywall) thanks to a breakthrough in developmental biology. So far, the mice can only be kept alive halfway through gestation. There’s a point at which the nutrient formula provided to them isn’t enough, and they need a blood supply to continue growing. That’s the next goal. For now, let’s talk about that mechanical womb setup.

Carousel of Care

The mechanical womb was developed to better understand how various factors such as gene mutations, nutrients, and environmental conditions affect murine fetuses in development. Why do miscarriages occur, and why do fertilized eggs fail to implant in the first place? How exactly does an egg explode into 40 trillion cells when things do work out? This see-through uterus ought to reveal a few more of nature’s gestational secrets.

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Alone, But Not Lonely: Remembering Astronaut Michael Collins

With many of the achievements of the Space Race now more than half a century behind us, it’s no wonder that we’re steadily losing the men who rode the rockets of the Mercury, Gemini, and Apollo programs into space. They were all very much in their primes at the time, but no matter what you’ve accomplished in life, even if it includes a trip to the Moon, time eventually catches up to you.

Still, it was quite a shock to learn today that astronaut Michael Collins passed away today at the age of 90. Collins made his trip to the Moon aboard Apollo 11, the mission which would see his crewmates Neil Armstrong and Edwin “Buzz” Aldrin descend to the surface in the Lunar Module Eagle and take the historic first steps on its surface in July of 1969.

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Exploring The World Of Nintendo 3DS Homebrew

When Nintendo officially ended production of the 3DS in September 2020, it wasn’t exactly a surprise. For one thing, some variation of the handheld system had been on the market since 2011. Which is not to say the product line had become stagnant: the system received a considerable mid-generation refresh, and there was even a more affordable variant introduced that dropped the eponymous stereoscopic 3D effect, but nearly a decade is still a fairly long life in the gaming industry. Of course Nintendo’s focus on the Switch, a hybrid device that blurs the line between console and handheld games, undoubtedly played a part in the decision to retire what could effectively be seen as a competing product.

While putting the 3DS out to pasture might have been the logical business move, a quick check on eBay seems to tell a different story. Whether it’s COVID keeping people indoors and increasing the demand for at-home entertainment, or the incredible library of classic and modern games the system has access to, the fact is that a used 3DS in good condition is worth more today than it was when it was brand new on the shelf this time last year.

I’ve certainly made more expensive mistakes.

In short, this was the worst possible time for me to decide that I finally wanted to buy a 3DS. Then one day I noticed the average price for a Japanese model was far lower than that of its American counterpart. I knew the hardware was identical, but could the firmware be changed?

An evening’s worth of research told me the swap was indeed possible, but inadvisable due to the difficulty and potential for unexpected behavior. Of course, that’s never stopped me before.

So after waiting the better part of a month for my mint condition 3DS to arrive from the land of the rising sun, I set out to explore the wide and wonderful world of Nintendo 3DS hacking.

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How Best To Get Your Project On Hackaday

We’re blessed to have such a great community at Hackaday. Our tipline often overfloweth with all manner of projects and builds of all stripes. We see it all here, from beginners just starting out with their first Arduino to diehard hackers executing daringly complex builds in their downtime, and everything in between.

If you’re sitting there in the grandstands, watching in awe, you might wonder what it takes to grace these hallowed black pages. In life, nothing is guaranteed, but I’ve been specially authorised to share with you a few tips that can maximise your chances of seeing your project on Hackaday.

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“Paper” Bottles For Your Fizzy Drinks (And Bottle Rockets)

A story that passed almost unnoticed was that the Coca-Cola company plan to run a limited trial of paper bottles. Wait, paper for a pressurized beverage? The current incarnation still uses a plastic liner and cap but future development will focus on a “bio-based barrier” and a bio composite or paper cap tethered to the vessel.

Given that plastic pollution is now a major global concern this is interesting news, as plastic drinks bottles make a significant contribution to that problem. But it raises several questions, first of all why are we seemingly unable to recycle the bottles in the first place, and given that we have received our milk and juice in paper-based containers for decades why has it taken the soda industry so long?

Plastic soft drink bottles are made from Polyethylene terephthalate or PET, the same polyester polymer as the one used in Dacron or Terylene fabrics. They’re blow-moulded, which is to say that an injection-moulded preform something like a plastic test tube with a screw top fitting is expanded from inside in a mould by compressed gas. As anyone who has experimented with bottle rockets will tell you, they are immensely strong, and as well as being cheap to make and transport they are also readily recyclable when separated from their caps.

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The Fascinating World Of Fasciation

The other day, I saw this gigantic mutant strawberry on reddit that looked like it had either been growing in a radiation zone, hitting the gym regularly, or sprinkled with magic dust. I immediately felt more than mildly interested in this phenomenon, which is called fasciation.

As it turns out, fasciation is fairly rare occurrence that nonetheless occurs in a wide variety of vascular plants. These mutant strawberries may be a bit unnerving to look at, but they are totally safe to eat. The only problem is that you’re more likely to come across a fasciated dandelion or daisy out in the wild than a strawberry or pineapple at the grocery store because the so-called ugly produce tends to be weeded out.

Fasciation is essentially unregulated tissue growth that occurs when the apical meristem, better known as the growing tip of the plant strays from shooting upward in cylindrical fashion and instead splays out flat, resulting in ribbon-like plant stems, elongated or multiple flower heads, and semi-circular strawberries.

Regular and fasciated mule’s ears from Wikipedia

Although fasciation tends to present as a flattened main stem, the phenomenon can occur nearly anywhere in the plant — the root, stem, leaves, flower heads, or fruit. It can be localized to just one area, or it affect the entire plant.

Fasciation gets compared to cancer because it has a number of causes and ways of expression, but it’s not quite as harmful or scary. Some races of plants exhibit extreme expression of fasciation. While it’s not fatal, it’s also not ideal, because the condition can result in broken tissues, distorted organization, and a decrease in fertility.

Fasciation: How does it work?

One absolute unit of dandelion. Image via Wild Yorkshire

Fasciation has many causes both internal and external. Internally, it happens because of a hormonal imbalance in the growth cells, a bacterial or viral infection, or a random genetic mutation. There are also environmental causes, like chemical exposure, cold and frost exposure, or fungi, mite, and insect attacks.

The wonder of fasciation knows no geographical, climatic, ecological, or taxonomical bounds among vascular plants. It equally affects annuals, biennials, and perennials; woody and herbaceous plants; shrubs, trees, and vines. Although fasciation can occur in any vascular plant, it is quite common in the rose (includes strawberries), legume, sunflower, and cactus families, and is often found among dandelions and snapdragons.

Some vascular plants are prone to fasciation and prized for it, like the cockscomb (Celosia cristata) flower. A few fasciated flora have even become objects of reverence, like the Virgin Mary appearing on a slice of toast. There was once a fasciated pumpkin vine growing in South India. The twenty-foot-long fasciated portion drew huge crowds of people to worship it, believing the vine to be an incarnation of King Cobra or Naga Sarpa, messenger of the god Vishnu.

This spring, I’ll be looking high and low for abnormal dandelions and daisies. I’ve already started scouting the produce at the grocery store for giant strawberries and found these two in the same box. Won’t you join me? We’re probably more likely to find fasciated fruits or flowers than four-leaf clovers.