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Mechanisms Behind Vaccine Side-Effects: The Science That Causes That Sore Arm

September 21, 2021 by 85 Comments

After receiving a vaccination shot, it’s likely that we’ll feel some side-effects. These can range from merely a sore arm to swollen lymph nodes and even a fever. Which side-effects to expect depend on the exact vaccine, with each type and variant coming with its own list of common side-effects. Each person’s immune system will also react differently, which makes it hard to say exactly what one can expect after receiving the vaccination.

What we can do is look closer at the underlying mechanisms that cause these side-effects, to try and understand why they occur and how to best deal with them. Most relevant here for the initial response is the body’s innate immune system, with dendritic cells generally being among the first to come into contact with the vaccine and to present the antigen to the body’s adaptive immune system.

Key to the redness, swelling, and fever are substances produced by the body which include various cytokines as well as prostaglandin, producing the symptoms seen with inflammation and injury.

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Hacking When It Counts: Surgery Fit To Save A Future King

September 20, 2021 by 43 Comments

When we picture the Medieval world, it conjures up images of darkness, privations, and sickness the likes of which are hard to imagine from our sanitized point of view. The 1400s, and indeed the entirety of history prior to the introduction of antibiotics in the 1940s, was a time when the merest scratch acquired in the business of everyday life could lead to an infection ending in a slow, painful death. Add in the challenges of war, where violent men wielding sharp things on a filthy field of combat, and it’s a wonder people survived at all.

But then as now, some people are luckier than others, and surviving what even today would likely be a fatal injury was not unknown, as one sixteen-year-old boy in 1403 would discover. It didn’t hurt that he was the son of the king of England, and when he earned an arrow in his face in combat, every effort would be made to save the prince and heir to the throne. It also helped that he had the good fortune to have a surgeon with the imagination to solve the problem, and the skill to build a tool to help.

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Green Roofs Could Help Improve Solar Panel Efficiency

September 20, 2021 by 83 Comments

There’s been a movement in architecture over the past couple of decades to help tie together large urban developments with plant life and greenery. We’ve seen a few buildings, and hundreds more renders, of tall skyscrapers and large buildings covered in vegetation.

The aesthetic is often a beautiful one, but the idea is done as much for its tangible benefits as for the sheer visual glory. Naturally, there’s the obvious boost from plants converting carbon dioxide into delicious, life-giving oxygen. However, greenery on the roofs of buildings could also help improve the output of solar installations, according to a recent study from Sydney, Australia.

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Farewell Sir Clive Sinclair; Inspired A Generation Of Engineers

September 16, 2021 by 74 Comments

It is with sadness that we note the passing of the British writer, engineer, home computer pioneer, and entrepreneur, Sir Clive Sinclair, who died this morning at the age of 81 after a long illness. He is perhaps best known among Hackaday readers for his ZX series of home computers from the 1980s, but over a lifetime in the technology industry there are few corners of consumer electronics that he did not touch in some way.

Sinclair’s first career in the 1950s was as a technical journalist and writer, before founding the electronics company Sinclair Radionics in the 1960s. His output in those early years was a mixture of miniature transistor radios and Hi-Fi components, setting the tone for decades of further tiny devices including an early LED digital watch at the beginning of the 1970s, miniature CRT TVs in the ’70s and ’80s, and another tiny in-ear FM radio which went on sale in the ’90s.

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a variety of enclosure options

The Many Ways To Solve Your Enclosure Problems

September 15, 2021 by 63 Comments

Most projects around here involve some sort of electronics, and some sort of box to put them in. The same is true of pretty much all commercially available electronic products as well.

Despite that, selecting an enclosure is far from a solved problem. For simple electronics it’s entirely possible to spend more time getting the case just right than working on the circuit itself. But most of the time we need to avoid getting bogged down in what exactly will house our hardware.

The array of options available for your housing is vast, and while many people default to a 3D printer, there are frequently better choices. I’ve been around the block on this issue countless times and wanted to share the options as I see them, and help you decide which is right for you. Let’s talk about enclosures!

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Angry antibodies

Monoclonal Antibodies: The Guided Missiles Of Medicine

September 15, 2021 by 11 Comments

Whenever anyone mentions the word “antibodies” these days, it’s sure to grab your attention. Thoughts generally flow to the human immune system and the role it plays in the ongoing COVID-19 pandemic, and to how our bodies fight off disease in general. The immune system is complex in the extreme, but pretty much everyone knows that antibodies are part of it and that they’re vital to the ability of the body to recognize and neutralize invaders like bacteria and viruses.

But as important as antibodies are to long-term immunity and the avoidance of disease, that’s far from all they’re good for. The incredible specificity of antibodies to their target antigens makes them powerful tools for biological research and clinical diagnostics, like rapid COVID-19 testing. The specificity of antibodies has also opened up therapeutic modalities that were once the stuff of science-fiction, where custom-built antibodies act like a guided missile to directly attack not only a specific protein in the body, but sometimes even a specific part of a protein.

Making these therapies work, though, requires special antibodies: monoclonal antibodies. These are very much in the news recently, not only as a possible treatment for COVID-19 but also to treat everything from rheumatoid arthritis to the very worst forms of cancer. But what exactly are monoclonal antibodies, how are they made, and how do they work?

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A bee pollinates a flower.

Even Bees Are Abuzz About Caffeine

September 13, 2021 by 33 Comments

Many of us can’t get through the day without at minimum one cup of coffee, or at least, we’d rather not think about trying. No matter how you choose to ingest caffeine, it is an awesome source of energy and focus for legions of hackers and humans. And evidently, the same goes for pollinator bees.

You’ve probably heard that there aren’t enough bees around anymore to pollinate all the crops that need pollinating. That’s old news. One solution was to raise them commercially and then truck them to farmers’ fields where they’re needed. The new problem is that the bees wander off and pollinate wildflowers instead of the fields they’re supposed to be pollinating. But there’s hope for these distracted bees: Scientists at the University of Greenwich have discovered that bees under the influence of caffeine are more likely to stay on track when given a whiff of the flower they’re supposed to be pollinating.

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