Do You Trust This AI For Your Surgery?

July 14, 2025 by Ian Bos 52 Comments

If you are looking for the perfect instrument to start a biological horror show in our age of AI, you have come to the right place. Researchers at Johns Hopkins University have successfully used AI-guided robotics to perform surgical procedures. So maybe a bit less dystopian, but the possibilities are endless.

Pig parts are used as surrogate human gallbladders to demonstrate cholecystectomies. The skilled surgeon is replaced with a Da Vinci research kit, similarly used in human controlled surgeries.

Researchers used an architecture that uses live imaging and human corrections to input into a high-level language model, which feeds into the controlling low-level model. While there is the option to intervene with human input, the model is trained to and has demonstrated the ability to self-correct. This appears to work fairly well with nothing but minor errors, as shown in an age-restricted YouTube video. (Surgical imagery, don’t watch if that bothers you.)

It’s noted that the robot performed slower than a traditional surgeon, trading time for precision. As always, when talking about anything medical, it’s not likely we will be seeing it on our own gallbladders anytime soon, but maybe within the next decade. If you want to read more on the specific advancements, check out the paper here.

Medical hacking isn’t always the most appealing for anyone with a weak stomach. For those of us with iron guts make sure to check out this precision tendon tester!

A balding man in a blue suit and tie sits behind rows of plants on tables. A bright yellow watering can is close to the camera and out of focus.

Phytoremediation To Clean The Environment And Mine Critical Materials

February 28, 2025 by Navarre Bartz 10 Comments

Nickel contamination can render soils infertile at levels that are currently impractical to treat. Researchers at UMass Amherst are looking at how plants can help these soils and source nickel for the growing EV market.

Phytoremediation is the use of plants that preferentially hyperaccumulate certain contaminants to clean the soil. When those contaminants are also critical materials, you get phytomining. Starting with Camelina sativa, the researchers are looking to enhance its preference for nickel accumulation with genes from the even more adept hyperaccumulator Odontarrhena to have a quick-growing plant that can be a nickel feedstock as well as produce seeds containing oil for biofuels.

Despite being able to be up to 3% Ni by weight, Odontarrhena was ruled out as a candidate itself due to its slow-growing nature and that it is invasive to the United States. The researchers are also looking into what soil amendments can best help this super Camelina sativa best achieve its goals. It’s no panacea for expected nickel demand, but they do project that phytomining could provide 20-30% of our nickel needs for 50 years, at which point the land could be turned back over to other uses.

Recycling things already in technical cycles will be important to a circular economy, but being able to remove contaminants from the environment’s biological cycles and place them into a safer technical cycle instead of just burying them will be a big benefit as well. If you want learn about a more notorious heavy metal, checkout our piece on the blessings and destruction wrought by lead.

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A researcher in a safety harness pollinates an American chestnut tree from a lift. Another researcher is on the other side of the lift and appears to be taking notes. The tree has bags over some of its branches, presumably to control the pollen that gets in. The lift has a grey platform and orange arm.

Hacking Trees To Bring Back The American Chestnut

November 29, 2024 by Navarre Bartz 36 Comments

“Chestnuts Roasting on an Open Fire” is playing on the radio now in the Northern Hemisphere which begs the question, “What happened to the American chestnut?” Would you be surprised to hear there’s a group dedicated to bringing it back from “functional extinction?” [via Inhabitat]

Between logging and the introduction of chestnut blight, the once prevalent American chestnut became increasingly uncommon throughout its traditional range in the Appalachians. While many trees in the southern range were killed by Phytophthora root rot (PRR), the chestnut blight leaves roots intact, so many chestnuts have been surviving by growing back from the roots only to succumb to the blight and be reborn again. Now, scientists are using a combination of techniques to develop blight-resistant trees from this remaining population.

The American Chestnut Foundation recognizes you can’t improve what you can’t measure and uses a combination of “small stem assays (SSAs) performed on potted seedlings, improved phenotype scoring methods for field-grown trees, and the use of genomic prediction models for scoring resistance based on genotype.” This allows them to more rapidly screen varieties for blight resistance to further their efforts. One approach is based on conventional plant breeding techniques and has been crossing blight and PRR-resistant Chinese chestnuts with the American type. PRR resistance has been found to be less genetically complicated, so progress has been faster on resistance to that particular problem. Continue reading “Hacking Trees To Bring Back The American Chestnut” →

An illustration of jellyfish swimming in the ocean by Rebecca Konte. The jellyfish are wearing cones on their "heads" to streamline their swimming that contain some sort of electronics inside.

The Six Million Dollar Jellyfish

March 1, 2024 by Navarre Bartz 14 Comments

What if you could rebuild a jellyfish: better, stronger, faster than it was before? Caltech now has the technology to build bionic jellyfish.

Studying the ocean given its influence on the rest of the climate is an important scientific task, but the wild pressure differences as you descend into the eternal darkness make it a non-trivial engineering problem. While we’ve sent people to the the deepest parts of the ocean, submersibles are much too expensive and risky to use for widespread data acquisition.

The researchers found in previous work that making a cyborg jellyfish was more effective than biomimetic jellyfish robots, and have now given the “biohybrid robotic jellyfish” a 3D-printed, neutrally buoyant, swimming cap. In combination with the previously-developed “pacemaker,” these cyborg jellyfish can explore the ocean (in a straight line) at 4.5x the speed of a conventional moon jelly while carrying a scientific payload. Future work hopes to make them steerable like the well-known robo-cockroaches.

If you’re interested in some other attempts to explore Earth’s oceans, how about drift buoys, an Open CTD, or an Open ROV? Just don’t forget to keep the noise down!

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Get Your Leafy Meats

June 26, 2023 by Brian McEvoy 23 Comments

Some of us jokingly refer to our hobbies as “mad science,” but [Justin] from The Thought Emporium could be one Igor away from living up to the jibe. The latest project to come out of the YouTube channel, video also after the break, outlines a map for creating an artificial organism in their new lab. The purpose is to test how far a citizen scientist can push the boundary of bioengineering. The stated goal is to create a swimming entity with a skeleton. The Thought Emporium also has a neuron project in the works, hinting at a potential crossover.

The artifishal [sic] organism has themes at the micro and macro scale. [Justin] says, “Cells are like little nano-robots. Mainly in the sense that they just follow their built-in instructions to the best of their ability.” At the multi-cellular level, the goal is to program something to actuate muscle tissue rhythmically to sustain locomotion. The method for creating living parts is decellularization and recellularization, a technique we heard about at Hackaday Belgrade.

The Thought Emporium is improving upon its protocol which removes cells from their “scaffolding” to repopulate it with the desired type, muscle in this case. Cellular scaffolds retain the shape of whatever they were, so whatever grows on them determines what they become. Once the technique of turning a leaf into muscle fibers is mastered, the next step will be creating bones with a different cell line that will mineralize the scaffold. Optimizing the processes and combining the results may show the world what is possible with the dedication of citizen bioengineers.

Regenerative medicine is looking at replacement human-parts with similar techniques. We are eager to see fish that digest plastic.

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A clear flexible PCB with a number of gold electrodes on one end. It is wrapped over a black cable to demonstrate its flexibility. A set of dashed white lines goes from one end to a zoomed in image of the circuit structure inset in the top right of the image.

Biohybrid Implant Patches Broken Nerves With Stem Cells

March 29, 2023 by Navarre Bartz 17 Comments

Neural interfaces have made great strides in recent years, but still suffer from poor longevity and resolution. Researchers at the University of Cambridge have developed a biohybrid implant to improve the situation.

As we’ve seen before, interfacing electronics and biological systems is no simple feat. Bodies tend to reject foreign objects, and transplanted nerves can have difficulty assuming new roles. By combining flexible electronics and induced pluripotent stem cells into a single device, the researchers were able to develop a high resolution neural interface that can selectively bind to different neuron types which may allow for better separation of sensation and motor signals in future prostheses.

As is typically the case with new research, the only patients to benefit so far are rats and only on the timescale of the study (28 days). That said, this is a promising step forward for regenerative neurology.

We’re no strangers to bioengineering here. Checkout how you can heal faster with electronic bandages or build a DIY vibrotactile stimulator for Coordinated Reset Stimulation (CRS).

(via Interesting Engineering)

Biological Hacking In The 19th Century Or How The World Almost Lost Wine

June 3, 2019 by Al Williams 24 Comments

While it isn’t quite universal, a lot of people enjoy a glass of wine now and again. But the world faced a crisis in the 1800s that almost destroyed some of the world’s great wines. Science — or some might say hacking — saved the day, even though it isn’t well known outside of serious oenophiles. You might wonder how biological hacking occurred in the 19th century. It did. It wasn’t as fast or efficient, but fortunately for wine drinkers, it got the job done.

When people tell me about new cybersecurity threats, I usually point out that cybercrime isn’t new. People have been stealing money, tricking people into actions, and impersonating other people for centuries. The computer just makes it easier. Even computing itself isn’t a new idea. Counting on your fingers and counting with electrons is just a matter of degree. Surely, though, mashing up biology is a more recent scientific advancement, right? While it is true that CRISPR can make editing genes a weekend garage project, people have been changing the biology of plants and animals for centuries using techniques like selective breeding and grafting. Not as effective, but sometimes effective enough.

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