A laboratory benchtop is shown. To the left, there is a distillation column above a collecting flask, with a tube leading from the flask to an adapter. The adapter has a frame holding a glass tube with a teflon stopper at one end, into which a smaller glass tube leads. At the other end of the larger tube is a round flask suspended in an oil bath.

Building A Rotary Evaporator For The Home Lab

September 8, 2025 by Aaron Beckendorf 6 Comments

The rotary evaporator (rotovap) rarely appears outside of well-provisioned chemistry labs. That means that despite being a fundamentally simple device, their cost generally puts them out of reach for amateur chemists. Nevertheless, they make it much more convenient to remove a solvent from a solution, so [Markus Bindhammer] designed and built his own.

Rotary evaporators have two flasks, one containing the solution to be evaporated, and one that collects the condensed solvent vapors. A rotary joint holds the evaporating flask partially immersed in a heated oil bath and connects the flask’s neck to a fixed vapor duct. Solvent vapors leave the first flask, travel through the duct, condense in a condenser, and collect in the second flask. A motor rotates the first flask, which spreads a thin layer of the solution across the flask walls, increasing the surface area and causing the liquid to evaporate more quickly.

Possibly the trickiest part of the apparatus is the rotary joint, which in [Markus]’s implementation is made of a ground-glass joint adapter surrounded by a 3D-printed gear adapter and two ball bearings. A Teflon stopper fits into one end of the adapter, the evaporation flask clips onto the other end, and a glass tube runs through the stopper. The ball bearings allow the adapter to rotate within a frame, the gear enables a motor to drive it, the Teflon stopper serves as a lubricated seal, and the non-rotating glass tube directs the solvent vapors into the condenser.

The flasks, condenser, and adapters were relatively inexpensive commercial glassware, and the frame that held them in place was primarily made of aluminium extrusion, with a few other pieces of miscellaneous hardware. In [Markus]’s test, the rotovap had no trouble evaporating isopropyl alcohol from one flask to the other.

This isn’t [Markus]’s first time turning a complex piece of scientific equipment into an amateur-accessible project, or, for that matter, making simpler equipment. He’s also taken on several major industrial chemistry processes.

Print PLA In PLA With A Giant Molecular Model Kit

May 12, 2025 by Tyler August 1 Comment

It isn’t too often we post a hack that’s just a pure 3D print with no other components, but for this Giant Molecular Model kit by [3D Printy], we’ll make an exception. After all, even if you print with PLA every day, how often do you get to play with its molecular bonds? (If you want to see that molecule, check out the video after the break.)

There are multiple sizes of bonds to represent bond lengths, and two styles: flexible and firm. Flexible bonds are great for multiple covalent bonds, like carbon-carbon bonds in organic molecules. The bonds clip to caps that screw in to the atoms; alternately a bond-cap can screw the atoms together directly. A plethora of atoms is available, in valence values from one to four. The two-bond atom has 180 and 120-degree variations for greater accuracy. In terms of the chemistry this kit could represent, you’re only limited by your imagination and how long you are willing to spend printing atoms and bonds.

[3D Printy] was kind enough to release the whole lot as CC0 Public Domain, so we might be seeing these at craft fairs, as there’s nothing to keep you from selling the prints. Honestly, we can only hope; from an educational standpoint, this is a much better use of plastic than endless flexy dragons.

If you’d prefer your chemistry toys help you do chemistry, try this fidget spinner centrifuge. Perhaps you’d rather be teaching electronics instead?

Continue reading “Print PLA In PLA With A Giant Molecular Model Kit” →

Big Chemistry: Cement And Concrete

May 7, 2025 by Dan Maloney 24 Comments

Not too long ago, I was searching for ideas for the next installment of the “Big Chemistry” series when I found an article that discussed the world’s most-produced chemicals. It was an interesting article, right up my alley, and helpfully contained a top-ten list that I could use as a crib sheet for future articles, at least for the ones I hadn’t covered already, like the Haber-Bosch process for ammonia.

Number one on the list surprised me, though: sulfuric acid. The article stated that it was far and away the most produced chemical in the world, with 36 million tons produced every year in the United States alone, out of something like 265 million tons a year globally. It’s used in a vast number of industrial processes, and pretty much everywhere you need something cleaned or dissolved or oxidized, you’ll find sulfuric acid.

Staggering numbers, to be sure, but is it really the most produced chemical on Earth? I’d argue not by a long shot, when there’s a chemical that we make 4.4 billion tons of every year: Portland cement. It might not seem like a chemical in the traditional sense of the word, but once you get a look at what it takes to make the stuff, how finely tuned it can be for specific uses, and how when mixed with sand, gravel, and water it becomes the stuff that holds our world together, you might agree that cement and concrete fit the bill of “Big Chemistry.”

Continue reading “Big Chemistry: Cement And Concrete” →

A picture of a single water droplet on top of what appears to be a page from a chemistry text. An orange particle is attached to the right side of the droplet and blue and black tendrils diffuse through the drop from it. Under the water drop, the caption tells us the reaction we're seeing is "K2Cr2O7+ 3H2O2 + 4H2SO4 = K2SO4+Cr2(SO4)3+7H2O+3O2(gas)"

Water Drops Serve As Canvas For Microchemistry Art

May 5, 2025 by Navarre Bartz 3 Comments

If you’re like us and you’ve been wondering where those viral videos of single water drop chemical reactions are coming from, we may have an answer. [yu3375349136], a scientist from Guangdong, has been producing some high quality microchemistry videos that are worth a watch.

While some polyglots out there won’t be phased, we appreciate the captioning for Western audiences using the elemental symbols we all know and love in addition to the Simplified Chinese. Reactions featured are typically colorful, but simple with a limited number of reagents. Being able to watch diffusion of the chemicals through the water drop and the results in the center when more than one chemical is used are mesmerizing.

We do wish there was a bit more substance to the presentation, and we’re aware not all readers will be thrilled to point their devices to Douyin (known outside of China as TikTok) to view them, but we have to admit some of the reactions are beautiful.

If you’re interested in other science-meets-art projects, how about thermal camera landscapes of Iceland, and given the comments on some of these videos, how do you tell if it’s AI or real anyway?

Simple Fluorometer Makes Nucleic Acid Detection Cheap And Easy

December 18, 2024 by Dan Maloney 9 Comments

Back in the bad old days, dealing with DNA and RNA in a lab setting was often fraught with peril. Detection technologies were limited to radioisotopes and hideous chemicals like ethidium bromide, a cherry-red solution that was a fast track to cancer if accidentally ingested. It took time, patience, and plenty of training to use them, and even then, mistakes were commonplace.

Luckily, things have progressed a lot since then, and fluorescence detection of nucleic acids has become much more common. The trouble is that the instruments needed to quantify these signals are priced out of the range of those who could benefit most from them. That’s why [Will Anderson] et al. came up with DIYNAFLUOR, an open-source nucleic acid fluorometer that can be built on a budget. The chemical principles behind fluorometry are simple — certain fluorescent dyes have the property of emitting much more light when they are bound to DNA or RNA than when they’re unbound, and that light can be measured easily. DIYNAFLUOR uses 3D-printed parts to hold a sample tube in an optical chamber that has a UV LED for excitation of the sample and a TLS2591 digital light sensor to read the emitted light. Optical bandpass filters clean up the excitation and emission spectra, and an Arduino runs the show.

The DIYNAFLUOR team put a lot of effort into making sure their instrument can get into as many hands as possible. First is the low BOM cost of around $40, which alone will open a lot of opportunities. They’ve also concentrated on making assembly as easy as possible, with a solder-optional design and printed parts that assemble with simple fasteners. The obvious target demographic for DIYNAFLUOR is STEM students, but the group also wants to see this used in austere settings such as field research and environmental monitoring. There’s a preprint available that shows results with commercial fluorescence nucleic acid detection kits, as well as detailing homebrew reagents that can be made in even modestly equipped labs.

Boss Byproducts: Calthemites Are Man-Made Cave Dwellers

November 20, 2024 by Kristina Panos 6 Comments

Some lovely orange calthemite flowstone colored so by iron oxide from rusting steel reinforcing. Image via Wikipedia

At this point, we’ve learned about man-made byproducts and nature-made byproducts. But how about one that’s a little of both? I’m talking about calthemites, which are secondary deposits that form in those man-made caves such as parking garages, mines, and tunnels.

Calthemites grow both on and under these structures in forms that mimic natural cave speleothems like stalactites, stalagmites, flowstone, and so on. They are often the result of an hyperalkalinic solution of pH 9-14 seeping through a concrete structure to the point of coming into contact with the air on the underside. Here, carbon dioxide in the air facilitates the necessary reactions to secondarily deposit calcium carbonate.

These calcium carbonate deposits are usually white, but can be colored red, orange, or yellow thanks to iron oxide. If copper pipes are around, copper oxide can cause calthemites to be blue or green. As pretty as all that sounds, I didn’t find any evidence of these parking garage growths having been turned into jewelry. So there’s your million-dollar idea.

Continue reading “Boss Byproducts: Calthemites Are Man-Made Cave Dwellers” →

A Tiny Chemistry Lab

November 8, 2024 by Bryan Cockfield 12 Comments

While advances in modern technology have allowed average people access to tremendous computing power as well as novel tools like 3D printers and laser cutters for a bare minimum cost, around here we tend to overlook some of the areas that have taken advantage of these trends as well. Specifically in the area of chemistry, the accessibility of these things have opened up a wide range of possibilities for those immersed in this world, and [Marb’s Lab] shows us how to build a glucose-detection lab in an incredibly small form factor.

The key to the build is a set of three laser-cut acrylic sheets, which when sandwiched together provide a path for the fluid to flow as well as a chamber that will be monitored by electronic optical sensors. The fluid is pumped through the circuit by a custom-built syringe pump driven by a linear actuator, and when the chamber is filled the reaction can begin. In this case, if the fluid contains glucose it will turn blue, which is detected by the microcontroller’s sensors. The color value is then displayed on a small screen mounted to the PCB, allowing the experimenter to take quick readings.

Chemistry labs like this aren’t limited to one specific reaction, though. The acrylic plates are straightforward to laser cut, so other forms can be made quickly. [Marb’s Lab] also made the syringe pump a standalone system, so it can be quickly moved or duplicated for use in other experiments as well. If you want to take your chemistry lab to the extreme, you can even build your own mass spectrometer.

Continue reading “A Tiny Chemistry Lab” →