Antiviral PPE For The Next Pandemic

August 19, 2025 by Navarre Bartz 34 Comments

In what sounds like the plot from a sci-fi movie, scientists have isolated an incredibly rare immune mutation to create a universal antiviral treatment.

Only present in a few dozen people worldwide, ISG15 immunodeficiency causes people to be more susceptible to certain bacterial illnesses, but it also grants the people with this condition immunity to known viruses. Researchers think that the constant, mild inflammation these individuals experience is at the root of the immunoresponse.

Where things get really interesting is how the researchers have found a way to stimulate protein production of the most beneficial 10 proteins of the 60 created by the natural mutation using 10 mRNA sequences inside a lipid nanoparticle. Lead researcher [Dusan Bogunovic] says “we have yet to find a virus that can break through the therapy’s defenses.” Researchers hope the treatment can be administered to first responders as a sort of biological Personal protective equipment (PPE) against the next pandemic since it would likely work against unknown viruses before new targeted vaccines could be developed.

Hamsters and mice were given this treatment via nasal drip, but how about intranasal vaccines when it comes time for human trials? If you want a short history of viruses or to learn how smartwatches could help flatten the curve for the next pandemic, we’ve got you covered.

A human hand in a latex glove holds a test tube filled with red liquid labeled H5N1. In the background is an out of focus image of a chicken.

Preparing For The Next Pandemic

May 2, 2025 by Navarre Bartz 69 Comments

While the COVID-19 pandemic wasn’t an experience anyone wants to repeat, infections disease experts like [Dr. Pardis Sabeti] are looking at what we can do to prepare for the next one.

While the next pandemic could potentially be anything, there are a few high profile candidates, and bird flu (H5N1) is at the top of the list. With birds all over the world carrying the infection and the prevalence in poultry and now dairy agriculture operations, the possibility for cross-species infection is higher than for most other diseases out there, particularly anything with an up to 60% fatality rate. Only one of the 70 people in the US who have contracted H5N1 recently have died, and exposures have been mostly in dairy and poultry workers. Scientists have yet to determine why cases in the US have been less severe.

To prevent an H5N1 pandemic before it reaches the level of COVID and ensure its reach is limited like earlier bird and swine flu variants, contact tracing of humans and cattle as well as offering existing H5N1 vaccines to vulnerable populations like those poultry and dairy workers would be a good first line of defense. So far, it doesn’t seem transmissible human-to-human, but more and more cases increase the likelihood it could gain this mutation. Keeping current cases from increasing, improving our science outreach, and continuing to fund scientists working on this disease are our best bets to keep it from taking off like a meme stock.

Whatever the next pandemic turns out to be, smartwatches could help flatten the curve and surely hackers will rise to the occasion to fill in the gaps where traditional infrastructure fails again.

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Hackaday Links: October 6, 2024

October 6, 2024 by Dan Maloney 22 Comments

Remember that time a giant cylindrical aquarium in a Berlin hotel bar catastrophically failed and left thousands of fish homeless? We sure do, and further recall that at the time, we were very curious about the engineering details of how this structure failed so spectacularly. At the time, we were sure there’d be plenty of follow-up on that score, but life happened and we forgot all about the story. Luckily, a faithful reader named Craig didn’t, and he helpfully ran down a few follow-up articles that came out last year that are worth looking at.

The first is from prosecutors in Berlin with a report offering three possibilities: that the adhesive holding together the acrylic panels of the aquarium failed; that the base of the tank was dented during recent refurbishment; or that the aquarium was refilled too soon after the repairs, leading to the acrylic panels drying out. We’re a little confused by that last one just from an intuitive standpoint, but each of these possibilities seems hand-wavy enough that the report’s executive summary could have been “Meh, Scheiße happens.”

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Pizza Elevator Is The Most Vital Pandemic Technology Of All

July 28, 2023 by Lewin Day 14 Comments

Remember the darkest days of lockdown and the pandemic? We were trying to distance ourselves from strangers wherever possible. [scealux]’s pizza elevator was spawned at this time to make apartment pizza deliveries as contactless as possible, and it’s charmingly branded to boot.

The build was intended to loft a pizza from street level to a third-floor balcony (by the American convention, ground floor is numbered one). Built with CNC-cut wooden parts, the elevator frame snap-fits on to the balcony railing. From there, a single spool runs out wire to four corners of the elevator platform.

As the crank is turned, the platform lowers under its own weight. The pizza can then be placed on the platform, and dinner can be lifted back up to the apartment. It’s a simple design, and one that manages to lift the pizza in a stable and flat fashion. With that said, we’d still like to see some anti-tip railings on a potential revision two.

Mock the branding all you will, it’s actually a smart design choice. The recognizable logo made the device’s purpose super obvious to the pizza delivery person, easing the introduction of the technology to a new user base.

If you want to make your own pizza instead of ordering out, you can automate that too.

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The Benefits Of Displacement Ventilation

July 7, 2022 by Lewin Day 27 Comments

The world has been shaken to its core by a respiratory virus pandemic. Humanity has been raiding the toolbox for every possible weapon in the fight, whether that be masks, vaccinations, or advanced antiviral treatments.

As far as medicine has come in tackling COVID-19 in the past two years, the ultimate solution would be to cut the number of people exposed to the pathogen in the first place. Improving our ventilation methods may just be a great way to cut down on the spread. After all, it’s what they did in the wake of the Spanish Flu.

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Turning Old Masks Into 3D Printer Filament

October 19, 2021 by Tom Nardi 23 Comments

Disposable masks have been a necessity during the COVID-19 pandemic, but for all the good they’ve done, their disposal represents a monumental ecological challenge that has largely been ignored in favor of more immediate concerns. What exactly are we supposed to do with the hundreds of billions of masks that are used once or twice and then thrown away?

If the research being conducted at the University of Bristol’s Design and Manufacturing Futures Lab is any indication, at least some of those masks might get a second chance at life as a 3D printed object. Noting that the ubiquitous blue disposable mask is made up largely of polypropylene and not paper as most of us would assume, the team set out to determine if they could process the masks in such a way that they would end up with a filament that could be run through a standard 3D printer. While there’s still some fine tuning to be done, the results so far are exceptionally impressive; especially as it seems the technique is well within the means of the hobbyist.

The first step in the process, beyond removing the elastic ear straps and any metal strip that might be in the nose, is to heat a stack of masks between two pieces of non-stick paper with a conventional iron. This causes the masks to melt together, and turn into a solid mass that’s much easier to work with. These congealed masks were then put through a consumer-grade blender to produce the fine polypropylene granules that’re suitable for extrusion.

Mounted vertically, the open source Filastruder takes a hopper-full of polypropylene and extrudes it into a 1.75 mm filament. Or at least, that’s the idea. The team notes that the first test run of filament only had an average diameter of 1.5 mm, so they’re modifying the nozzle and developing a more powerful feed mechanism to get closer to the goal diameter. Even still, by cranking up the extrusion multiplier in the slicing software, the team was able to successfully print objects using the thin polypropylene filament.

This is only-during-a-pandemic recycling, and we’re very excited to see this concept developed further. The team notes that the extrusion temperature of 260 °C (500 °F) is far beyond what’s necessary to kill the COVID-19 virus, though if you planned on attempting this with used masks, we’d imagine they would need to be washed regardless. If the hacker and maker community were able to use their 3D printers to churn out personal protective equipment (PPE) in the early days of the pandemic, it seems only fitting that some of it could now be ground up and printed into something new.

Fight Disease With A Raspberry Pi

September 20, 2021 by Bryan Cockfield 4 Comments

Despite the best efforts of scientists around the world, the current global pandemic continues onward. But even if you aren’t working on a new vaccine or trying to curb the virus with some other seemingly miraculous technology, there are a few other ways to help prevent the spread of the virus. By now we all know of ways to do that physically, but now thanks to [James Devine] and a team at CERN we can also model virus exposure directly on our own self-hosted Raspberry Pis.

The program, called the Covid-19 Airborne Risk Assessment (CARA), is able to take in a number of metrics about the size and shape of an area, the number of countermeasures already in place, and plenty of other information in order to provide a computer-generated model of the number of virus particles predicted as a function of time. It can run on a number of different Pi hardware although [James] recommends using the Pi 4 as the model does take up a significant amount of computer resources. Of course, this only generates statistical likelihoods of virus transmission but it does help get a more accurate understanding of specific situations.

For more information on how all of this works, the group at CERN also released a paper about their model. One of the goals of this project is that it is freely available and runs on relatively inexpensive hardware, so hopefully plenty of people around the world are able to easily run it to further develop understanding of how the virus spreads. For other ways of using your own computing power to help fight Covid, don’t forget about Folding@Home for using up all those extra CPU and GPU cycles.