insulin

9 Articles

An Insulin Injection That Lasts For Days: A New Hope For Diabetics

December 27, 2023 by 12 Comments

A major challenge for people who have a form of diabetes is the need to regulate the glucose levels in their body. Normally this is where the body’s insulin-producing cells would respond to glucose with a matching amount of insulin, but in absence of this response it is up to the patient to manually inject insulin. Yet recent research offers the hope that these daily injections might be replaced with weekly injections, using insulin-binding substances that provide a glucose-response rather like the natural one. One such approach was tested by Juan Zhang and colleagues, with the results detailed in Nature Biomedical Engineering.

In this study, the researchers injected a group of diabetic (type 1) mice and minipigs with the formulation, consisting out of gluconic acid-modified recombinant human insulin bound to a glucose-responsive phenylboronic acid-diol complex. The phenylboronic acid element binds more easily to glucose, which results in the insulin being released, with no significant hypoglycemia observed in this small non-human test group. A major advantage of this mechanism is that it is fully self-regulating through the amount of glucose present in the blood.

This study is similar to work by Sijie Xian and colleagues published in Advanced Materials (ChemRxiv preprint) where a similar complex of glucose-sensitive, bound insulin complex was studied, albeit in vitro. With non-human animal testing showing good results for this method, human trials may not be far off, which could mean the end to daily glucose and insulin management for millions in the US alone.

(Top image: Chemical structures of the insulin-DiPBA complex and its functioning. Credit: Sijie Xian et al., 2023)

Implant Fights Diabetes By Making Insulin And Oxygen

October 10, 2023 by 13 Comments

Type 1 diabetes remains a problem despite having an apparently simple solution: since T1D patients have lost the cells that produce insulin, it should be possible to transplant those cells into their bodies and restore normal function. Unfortunately, it’s not actually that simple, and it’s all thanks to the immune system, which would attack and destroy transplanted pancreas cells, whether from a donor or grown from the patient’s own stem cells.

That may be changing, though, at least if this implantable insulin-producing bioreactor proves successful.  The device comes from MIT’s Department of Chemical Engineering, and like earlier implants, it relies on encapsulating islet cells, which are the insulin-producing cells within the pancreas, inside a semipermeable membrane. This allows the insulin they produce to diffuse out into the blood, and for glucose, which controls insulin production in islet cells, to diffuse in. The problem with this arrangement is that the resource-intensive islet cells are starved of oxygen inside their capsule, which is obviously a problem for the viability of the implant.

The solution: electrolysis. The O2-Macrodevice, as the implant is called, uses a tiny power-harvesting circuit to generate oxygen for the islet cells directly from the patient’s own interstitial water. The circuit applies a current across a proton-exchange membrane, which breaks water molecules into molecular oxygen for the islet cells. The hydrogen is said to diffuse harmlessly away; it seems like that might cause an acid-base imbalance locally, but there are plenty of metabolic pathways to take care of that sort of thing.

The implant looks promising; it kept the blood glucose levels of diabetic mice under control, while mice who received an implant with the oxygen-generating cell disabled started getting hyperglycemic after two weeks. What’s really intriguing is that the study authors seem to be thinking ahead to commercial production, since they show various methods for mass production of the cell chamber from standard 150-mm silicon wafers using photolithography.

Type 1 diabetics have been down the “artificial pancreas” road before, so a wait-and-see approach is clearly wise here. But it looks like treating diabetes less like a medical problem and more like an engineering problem might just pay dividends.

Picture of NanoStat in 3D-printed enclosure with LiPo battery and US quarter for scale.

An ESP32-Based Potentiostat

December 27, 2022 by 3 Comments

Ever wanted to make your own wireless chemical sensor? Researchers from the University of California, Irvine (UC Irvine) have got you covered with their ESP32-based potentiostat.

We’ve talked about potentiostats here on Hackaday before. Potentiostats are instruments that analyze the electrical properties of an electroactive chemical cell. Think oxidation and reduction reactions (redox) from your chemistry course, if you can remember that far back. Potentiostats can be used in several different modes/configurations, but the general idea is for these instruments to induce redox reactions within a given electroactive chemical cell and then measure the resulting current produced by the reaction. By measuring the current, researchers can determine the concentration of a known substance within a sample or even determine the identity of an unknown substance, to name a few potential applications.

These instruments have become mainstays in research labs around the world and have incredible utility in the consumer space. Glucometers, devices used to measure blood glucose levels, are an example of technologies that have made their way into everyday life due to the advances made in electrochemistry and potentiostat research over the last few decades. Given their incredible utility to scientific research and medical technologies, a great deal of effort has gone into democratizing potentiostats, making them more available to the general public for educational and hobbyist purposes. Of course, any medical applications must go through rigorous testing and approvals by each country’s appropriate governing bodies. So we’re talking more non-medical purposes here.

The first popular open-source, DIY potentiostat was the CheapStat, which we’ve covered here on Hackaday before. Since then, developing newer and more advanced open-source potentiostats has become a popular endeavor within the scientific community. The researchers from UC Irvine wanted to put their own special spin on the open-source potentiostat craze and they did so with their inclusion of the ESP32 as their main processor. This obviously opens up them up do a whole host (see what we did there) of wireless capabilities that others before them have not explored.

With the ESP32, they developed a nice web-based GUI that makes controlling and collecting data from the potentiostat very seamless and user-friendly. You can imagine the great possibilities here. Teacher-led classroom demonstrations where the instructor can easily access each student’s device over the cloud to help troubleshoot or explain results. Developing soil monitoring sensors that can be deployed all around a farm to remotely collect data on feed, soil composition, and plant health. The possibilities here sure are promising.

We hope you’ll dive into their paper as it’s well worth a read. Happy hacking, Hackaday.

Electronic Treatment For Diabetes?

October 9, 2020 by 24 Comments

If you ask power companies and cell phone carriers how much electromagnetic radiation affects the human body, they’ll tell you it doesn’t at any normal levels. If you ask [Calvin Carter] and some other researchers at the University of Iowa, they will tell you that it might treat diabetes. In a recent paper in Cell Metabolism, they’ve reported that exposing patients to static magnetic and electric fields led to improved insulin sensitivity in diabetic mice.

Some of the medical jargon in a paper like this one can be hard to follow, but it seems they feed mice on a bad diet — like that which many of us may eat — and exposed them to magnetic and electrical fields much higher than that of the Earth’s normal fields. After 30 days there was a 33% improvement in fasting blood glucose levels and even more for some mice with a specific cause of diabetes.

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A Sweet Little Insulin Reminder Light

May 19, 2020 by 5 Comments

So much of what we do relies on a certain societal structure that has been absent for a few months now. When the days run together, it’s hard to remember to do the things that must happen daily. You think you did something, and maybe you’re right, but it’s quite possible you’re thinking of yesterday.

[Flameeyes] has diabetes and must use an insulin pen every morning without fail, no matter what’s happening outside his door. This was pretty much a non-issue in the before-time, but quickly became a serious problem as the routine-free weeks wore on. With no room for false positives, he needed a solution that doesn’t trigger until the deed is done.

Now when [Flameeyes] puts the pen away, he also triggers a Flic smart button mounted nearby. The Flic shares its status with a Feather M4 Express through a web app, and the Feather in turn changes the RGB LED inside of Pikachu’s base from red to yellow for the day. Pikachu sits in plain sight by the kettle, so there’s no guessing whether [Flameeyes] took his insulin.

Insulin is a critical commodity with a lot of DIY interest, which is probably starting to spike about now. Our own [Dan Maloney] wrote a great piece on the subject that brings up an insulin hack from around 80 years ago.

Homebrew Pancreas Gets 30 Minutes Of Fame

August 9, 2018 by 25 Comments

It is pretty unusual to be reading Bloomberg Businessweek and see an article with the main picture featuring a purple PCB (the picture above, in fact). But that’s just what we saw this morning. The story is about an open source modification to an insulin pump known as the RileyLink. This takes advantage of older Medtronic brand insulin pumps and allows you to control the BLE device from a smartphone remotely and use more sophisticated software to control blood sugar levels.

Of course, the FDA isn’t involved. If they were, the electronics would cost $7,000 instead of $250 — although, in fairness, that $250 doesn’t cover the cost of the used pump. Why it has to be a used pump is a rather interesting story. The only reason the RileyLink is possible is due to a security flaw and an active hacker community.

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Ask Hackaday: Preserving Electronic Devices

December 20, 2017 by 62 Comments

Conventional wisdom holds that we no longer make things to last for the long haul, and that we live in a disposable world. It’s understandable — after all, most of us have a cell phone in our pocket that’s no more than a year or two old, and it’s often cheaper to buy a new printer than replace the ink cartridges. But most of that disposability is driven by market forces, like new software that makes a device obsolete long before it breaks down, or the razor and blades model that makes you pay through the nose for ink. It turns out that most electronic devices are actually pretty well engineered, and as long as they’re not abused can still be operating decades down the road.

But what happens when you want to put an electromechanical device away and preserve it for a rainy day? What can you do to make sure the device will operate again a few years down the road? Are there steps one can take beyond the typical “keep it in a cool, dry place” advice? In short, how do you preserve electronic devices?

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