The start of World War II threw quantum theory research into disarray. Many of the European physicists left Europe all together, and research moved across the ocean to the shores of the United States. The advent of the atomic bomb thrust American physicists into the spotlight, and physicists began to meet on Shelter Island to discuss the future of quantum theory. By this time one thing was certain: the Copenhagen interpretation of quantum theory had triumphed and challenges to it had mostly died off.
This allowed physicists to focus on a different kind of problem. At this point in time quantum theory was not able to deal with transitional states of particles when they are created and destroyed. It was well known that when an electron came into contact with a positron, the two particles were destroyed and formed at least two photons with a very high energy, known as gamma rays. On the flip side, gamma ray photons could spontaneously turn into positron-electron pairs.
No one could explain why this occurred. It had become obvious to the physicists of the day that a quantum version of Maxwell’s electromagnetic field theory was needed to explain the phenomenon. This would eventually give rise to QED, short for quantum electrodynamics. This is a severely condensed story of how that happened.