Neural interfaces have made great strides in recent years, but still suffer from poor longevity and resolution. Researchers at the University of Cambridge have developed a biohybrid implant to improve the situation.
As we’ve seen before, interfacing electronics and biological systems is no simple feat. Bodies tend to reject foreign objects, and transplanted nerves can have difficulty assuming new roles. By combining flexible electronics and induced pluripotent stem cells into a single device, the researchers were able to develop a high resolution neural interface that can selectively bind to different neuron types which may allow for better separation of sensation and motor signals in future prostheses.
As is typically the case with new research, the only patients to benefit so far are rats and only on the timescale of the study (28 days). That said, this is a promising step forward for regenerative neurology.
Bioelectronics has been making great strides in recent years, but interfacing rigid electrical components with biological systems that are anything but can prove tricky. Researchers at the Laboratory for Organic Electronics (LOE) have found a way to bridge the gap with conductive gels. (via Linköping University)
Outside the body, these gels are non-conductive, but when injected into a living animal, the combination of gel and the body’s metabolites creates a conductive electrode that can move with the tissue. This is accompanied by a nifty change in color which makes it easy for researchers to see if the electrode has formed properly.
Applications for the technology include better biological sensors and enhanced capabilities for future brain-controlled interfaces. The study was done on zebrafish and medicinal leeches, so it will be awhile before you can pick up a syringe of this stuff at your local computer store, but it still offers a tantalizing glimpse of the future.
We’re a long way from the dermal regenerators in Star Trek, but researchers at Northwestern University have made a leap forward in the convenient use of electrotherapy for wound healing.
Using a ring and center “flower” electrode, this bioresorbable molybdenum device restores the natural bioelectric field across a wound to stimulate healing in diabetic ulcers. Only 30 minutes of electrical stimulation per day was able to show a 30% improvement in healing speed when used with diabetic mice. Power is delivered wirelessly and data is transmitted back via NFC, meaning the device can remain on a patient without leaving them tethered when not being treated.
Healing can be tracked by the change in electrical resistance across the wound since the wound will dry out as it heals. Over a period of six months, the central flower electrode will dissolve into the patient’s body and the rest of the device can be removed. Next steps include testing in a larger animal model and then clinical trials on human diabetic patients.
The possibility of a table saw accident is low, but never zero — and [Nerdforge] has lost a finger to this ever-useful but dangerous contraption. For a right-handed person, losing the left hand pinky might not sound like much, but the incident involved some nerve damage as well, making inaccessible a range of everyday motions we take for granted. For instance, holding a smartphone or a pile of small objects without dropping them. As a hacker, [Nerdforge] decided to investigate just how much she could do about it.
On Thingiverse, she’s hit a jackpot: a parametric prosthetic finger project by [Nicholas Brookins], and in no time, printed the first version in resin. The mechanics of the project are impressive in their simplicity — when you close your hand, the finger closes too. Meant to be as simple as possible, this project only requires a wrist mount and some fishing line. From there, what could she improve upon? Aside from some test fits, the new finger could use a better mounting system, it could stand looking better, and of course, it could use some lights.
For a start, [Nerdforge] redesigned the mount so that the finger would instead fasten onto a newly-fingerless glove, with a few plastic parts attached into that. Those plastic parts turned out to be a perfect spot for a CR2032 battery holder and a microswitch, wired up to a piece of LED filament inserted into the tip of the finger. As for the looks, some metal-finish paint was found to work wonders – moving the glove’s exterior from the “printed project” territory into the “futuristic movie prop” area.
The finger turned out to be a resounding success, restoring the ability to hold small objects in ways that the accident made cumbersome. It doesn’t provide much in terms of mechanical strength, but it wasn’t meant to do that. Now, [Nerdforge] has hacked back some of her hand’s features, and we have yet another success story for all the finger-deficient hackers among us. Hacker-built prosthetics have been a staple of Hackaday, with the OpenBionics project in particular being a highlight of 2015 Hackaday Prize — an endearing demonstration of hackers’ resilience.
Plastic waste is a major problem, but what if you could turn the world’s trash into treasure? [Yayasan Kaki Kita Sukasada (YKKS)] in Indonesia is doing this by using recycled plastic to make prosthetic legs.
Polypropylene source material is shredded and formed into a sheet which is molded into the required shape for the socket. A layer of cloth and foam is used to cushion the interface between the patient and the socket itself. Using waste plastic to make parts for the prosthetics lowers the price for patients as well as helps to keep this material out of the landfill.
What makes this project really exciting is that [YKKS] employs disabled people who develop the prosthetics and also trains patients on how to maintain and repair their prosthetics with easily sourced tools and materials. With some medical device companies abandoning their devices, this is certainly a welcome difference.
Shape shifters have long been the stuff of speculative fiction, but researchers in China have developed a magnetoactive phase transitional matter (MPTM) that makes Odo slipping through an air vent that much more believable.
Soft robots can squeeze into small spaces or change shape as needed, but many of these systems aren’t as strong as their more mechanically rigid siblings. Inspired by the sea cucumber’s ability to manipulate its rigidity, this new MPTM can be inductively heated to a molten state to change shape as well as encapsulate or release materials. The neodymium-iron-boron (NdFeB) microparticles suspended in gallium will then return to solid form once cooled.
Applications in drug delivery, foreign object removal, and smart soldering (video after the break) probably have more real world impact than the LEGO minifig T1000 impersonation, despite how cool that looks. While a pick-and-place can do better soldering work on a factory line, there might be repair situations where a magnetically-controlled solder system could come in handy.
Modern techniques of Coordinated Reset Stimulation (CRS), which is usually administered with invasive deep brain stimulation, can have a miraculous effect on those suffering from Parkinson’s disease. However, the CRS technique can also apparently be administered via so-called vibrotactile CRS (vCRS) which essentially means vibrating certain nerve endings corresponding to brain regions that have a large cortical representation.
An example is vibrating the tips of the fingers using special gloves. This is a medical technique and as such is governed by the FDA. With ongoing trials, patients all around the world will simply have to wait. [HackyDev] has been working with a group of people on developing an open source vCRS glove.
This neuromodulation technique seems so promising, that this upfront effort by hackers around the world is simply a joy to see. Patents be dammed; we can work around them. Interested parties can follow the (very long, tricky-to-follow) thread here.
The hardware [HackyDev] put together uses a nodeMCU as the controller, driving eight motor coils via MOSFETS. The finger-mounted actuators are constructed by ripping the electromagnet out of a relay and mounting it in a 3D printed frame, with a magnet suspended on a spring. This part is mounted on each finger. The nodeMCU presents a simple web form that enables the configuration of the pulse parameters.
A permanent magnet is housed in the spring’s top section
The way the gloves appear to work is due to the way the body perceives sensory input, with a massive bias towards the hands and mouth region, referred to as the cortical homunculus. Each finger has an individual haptic element, which is actuated in a specific sequence with a carefully formed pulse at approx. 250 Hz.
This appears to activate similar in-brain effects as traditional (and invasive) DBS therapy by effectively de-synchronizing certain over-synchronized brain pathways and alleviating the overactive ß-wave activity in the brain. And this calms the tremors as well as many other PD symptoms. It’s all very exciting stuff, and we’ll be following this story closely.
For more on the backstory check out the 2017 paper by Peter A. Tass, as well as this later one, and this one. We’ve seen some recent success with diagnosing or at least detecting PD, by smell as well as via audio, so the future might look a little brighter for quite a number of people.
